INT65928

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.34
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Rac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Botox 16 100.00 Very High Very High Very High
Lamotrigine 1 100.00 Very High Very High Very High
Gabapentin 1 100.00 Very High Very High Very High
intrathecal 1 99.78 Very High Very High Very High
Nerve growth factor 18 99.56 Very High Very High Very High
Analgesic 2 99.12 Very High Very High Very High
Pain 7 98.64 Very High Very High Very High
tolerance 1 98.16 Very High Very High Very High
Hippocampus 8 96.12 Very High Very High Very High
local anesthetic 1 94.80 High High
Disease Link Frequency Relevance Heat
Fibrosis 6 100.00 Very High Very High Very High
Esophageal Motility Disorder 8 97.36 Very High Very High Very High
Disease 8 97.24 Very High Very High Very High
Sleep Disorders 4 95.84 Very High Very High Very High
Demyelinating Disease 5 93.08 High High
Pneumonia 1 88.76 High High
Ganglion Cysts 2 88.44 High High
Gastroesophageal Reflux Disease 1 87.76 High High
Angina 23 87.36 High High
Pheochromocytoma 2 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of NADPH oxidase by transient transfection of a dominant negative Rac1 mutant (RacN17) plasmid blocked NGF-stimulated TRPV1 protein expression, while expression of a constitutively active Rac1 increased basal and NGF-stimulated TRPV1 levels.
Positive_regulation (increased) of Gene_expression (expression) of Rac1 associated with nerve growth factor
1) Confidence 0.42 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.21 Pain Relevance 0.48
NGF stimulated NADPH oxidase activity, while 24 h exposure further increased expression of the Rac1 and gp91(phox) subunits of the holoenzyme.
Positive_regulation (increased) of Gene_expression (expression) of Rac1 associated with nerve growth factor
2) Confidence 0.42 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.24 Pain Relevance 0.46
[Evaluation of analgesic protocol with nitrous oxide and EMLA cream during botulinum toxin injections in children].
Positive_regulation (during) of Gene_expression (injections) of botulinum toxin associated with pain and analgesic
3) Confidence 0.41 Published 2007 Journal Ann Readapt Med Phys Section Title Doc Link 17337081 Disease Relevance 0 Pain Relevance 0.54
We conclude that botulinum toxin injection at the gastroesophageal junction leads to significant symptom improvement in patients with nonachalasia esophageal motility disorders.
Positive_regulation (leads) of Gene_expression (injection) of botulinum toxin associated with esophageal motility disorder
4) Confidence 0.40 Published 1996 Journal Dig. Dis. Sci. Section Abstract Doc Link 8888717 Disease Relevance 0.81 Pain Relevance 0.08
The authors recommend continued use of 30-gauge needles for botulinum toxin injection in the office setting.


Positive_regulation (needles) of Gene_expression (injection) of botulinum toxin
5) Confidence 0.40 Published 2009 Journal Ophthal Plast Reconstr Surg Section Body Doc Link 19966651 Disease Relevance 0.05 Pain Relevance 0
If this reduced the pain, they were then offered treatment with botulinum toxin.
Positive_regulation (offered) of Gene_expression (offered) of botulinum toxin
6) Confidence 0.40 Published 2009 Journal J Laryngol Otol Section Body Doc Link 18588738 Disease Relevance 0.08 Pain Relevance 0
Management was predominantly surgical; however, seven recently diagnosed patients opted for botulinum toxin (botox) injection as the first line of treatment.
Positive_regulation (opted) of Gene_expression (injection) of botulinum toxin associated with botox
7) Confidence 0.40 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12452392 Disease Relevance 0.82 Pain Relevance 0.17
Several new therapies, including tizanidine, intrathecal baclofen, botulinum toxin injections, gabapentin, ondansitron, thalamic stimulation, and lamotrigine, increase our treatment options.
Positive_regulation (increase) of Gene_expression (injections) of botulinum toxin associated with lamotrigine, gabapentin and intrathecal
8) Confidence 0.40 Published 1998 Journal Semin Neurol Section Abstract Doc Link 9817541 Disease Relevance 0.54 Pain Relevance 0.37
They were transfected with recombinant adenoviruses to express constitutive active (CA) or dominant negative (DN) forms of RhoA, Rac1, or Cdc42 under the control of the CAG promoter, along with marker genes (?
Positive_regulation (forms) of Gene_expression (express) of Rac1
9) Confidence 0.32 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.28 Pain Relevance 0.23
A retrospective study of 44 patients, including 18 patients who received pneumatic dilatation and 10 patients who received botulinum toxin before pneumatic dilatation, or in whom botulinum toxin injection initially failed, found that these preliminary procedures did not affect the results of myotomy in terms of outcome or complications [31] An increase in the complication rate (50% with perforation) and a fibrotic lower oesophageal sphincter were observed only in a small subgroup of four patients in whom botulinum toxin injection initially failed [31] Another investigation analysing 15 patients receiving myotomy after prior BTX treatment reports on difficulties in dissection of the submucosal plane in 8 of the 15 patients and a perforation in 2 of the 15 patients (13,3%) which is a significant higher perforation rate than the perforation rate observed in patients without prior BTX treatment.21 However, these findings were not confirmed in a retrospective study of 92 patients, with results published in 1999 and 2000, including 22 patients who received pneumatic dilatation and 10 patients who received botulinum toxin.
Positive_regulation (after) of Gene_expression (injection) of botulinum toxin associated with fibrosis
10) Confidence 0.07 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC122056 Disease Relevance 0.10 Pain Relevance 0
A retrospective study of 44 patients, including 18 patients who received pneumatic dilatation and 10 patients who received botulinum toxin before pneumatic dilatation, or in whom botulinum toxin injection initially failed, found that these preliminary procedures did not affect the results of myotomy in terms of outcome or complications [31] An increase in the complication rate (50% with perforation) and a fibrotic lower oesophageal sphincter were observed only in a small subgroup of four patients in whom botulinum toxin injection initially failed [31] Another investigation analysing 15 patients receiving myotomy after prior BTX treatment reports on difficulties in dissection of the submucosal plane in 8 of the 15 patients and a perforation in 2 of the 15 patients (13,3%) which is a significant higher perforation rate than the perforation rate observed in patients without prior BTX treatment.21 However, these findings were not confirmed in a retrospective study of 92 patients, with results published in 1999 and 2000, including 22 patients who received pneumatic dilatation and 10 patients who received botulinum toxin.
Neg (failed) Positive_regulation (failed) of Gene_expression (injection) of botulinum toxin associated with fibrosis
11) Confidence 0.07 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC122056 Disease Relevance 0.10 Pain Relevance 0
A retrospective study of 44 patients, including 18 patients who received pneumatic dilatation and 10 patients who received botulinum toxin before pneumatic dilatation, or in whom botulinum toxin injection initially failed, found that these preliminary procedures did not affect the results of myotomy in terms of outcome or complications [31] An increase in the complication rate (50% with perforation) and a fibrotic lower oesophageal sphincter were observed only in a small subgroup of four patients in whom botulinum toxin injection initially failed [31] Another investigation analysing 15 patients receiving myotomy after prior BTX treatment reports on difficulties in dissection of the submucosal plane in 8 of the 15 patients and a perforation in 2 of the 15 patients (13,3%) which is a significant higher perforation rate than the perforation rate observed in patients without prior BTX treatment.21 However, these findings were not confirmed in a retrospective study of 92 patients, with results published in 1999 and 2000, including 22 patients who received pneumatic dilatation and 10 patients who received botulinum toxin.
Positive_regulation (after) of Gene_expression (injection) of botulinum toxin associated with fibrosis
12) Confidence 0.07 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC122056 Disease Relevance 0.10 Pain Relevance 0

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