INT65944

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Context Info
Confidence 0.33
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Dnmt1) nucleus (Dnmt1) DNA binding (Dnmt1)
protein complex (Dnmt1) transcription factor binding (Dnmt1)
Anatomy Link Frequency
plasma 1
brain 1
Dnmt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 7 86.00 High High
isoflurane 4 84.16 Quite High
Pain 2 78.72 Quite High
medulla 1 35.20 Quite Low
Disease Link Frequency Relevance Heat
Aging 3 98.98 Very High Very High Very High
Disease 1 95.60 Very High Very High Very High
Pain 2 78.72 Quite High
Obesity 5 78.16 Quite High
Sprains And Strains 1 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animal models of aging manifest alteration of brain Ca2+ homeostasis and increased methyltransferase I (PLMTI) activity.
Positive_regulation (increased) of methyltransferase I in brain associated with aging
1) Confidence 0.33 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890927 Disease Relevance 0.40 Pain Relevance 0.20
A wide spectrum of structurally disparate inhalational anesthetics reduce brain synaptic plasma membrane Ca(2+)-ATPase (PMCA) activity, whereas phospholipid methyltransferase I (PLMTI) is enhanced by anesthetics.
Positive_regulation (enhanced) of phospholipid methyltransferase I in plasma
2) Confidence 0.17 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890928 Disease Relevance 0.36 Pain Relevance 0.19

General Comments

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