INT65948

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Context Info
Confidence 0.31
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.38
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNASE1L3) DNA binding (DNASE1L3) DNA metabolic process (DNASE1L3)
Anatomy Link Frequency
hepatocytes 2
central nervous system 1
heart 1
DNASE1L3 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 14 100.00 Very High Very High Very High
Central nervous system 9 100.00 Very High Very High Very High
lidocaine 6 100.00 Very High Very High Very High
sSRI 29 98.96 Very High Very High Very High
Neurotransmitter 21 94.88 High High
depression 11 94.04 High High
Nicotine 103 89.92 High High
Serotonin 39 82.96 Quite High
addiction 41 80.36 Quite High
cocaine 8 79.96 Quite High
Disease Link Frequency Relevance Heat
Depression 11 94.04 High High
Schizophrenia 17 91.00 High High
Anxiety Disorder 81 87.12 High High
Stress 8 80.44 Quite High
Drug Dependence 8 80.36 Quite High
Alcohol Addiction 4 77.04 Quite High
Mental Disorders 12 73.72 Quite High
Death 2 67.76 Quite High
Poisoning 16 66.60 Quite High
Injury 2 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus.
LSD Spec (examined) Binding (interaction) of associated with fluoxetine
1) Confidence 0.31 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890940 Disease Relevance 0 Pain Relevance 0.36
These results are consistent with anecdotal reports of interactions between LSD and acutely administered SSRIs in humans.
LSD Binding (interactions) of associated with ssri
2) Confidence 0.31 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890940 Disease Relevance 0 Pain Relevance 0.39
This metabolite therefore holds promise as a biomarker for LSD use in the forensic toxicology laboratories.
LSD Binding (biomarker) of
3) Confidence 0.12 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0 Pain Relevance 0
Recent studies on LSD metabolism in human liver microsomes and hepatocytes not only confirmed the formation of 2-oxo-3-HO-LSD but also identified a 2,3-dihydroxy-LSD metabolite (60).
LSD Binding (metabolism) of in hepatocytes
4) Confidence 0.12 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0 Pain Relevance 0
Recent studies on LSD metabolism in human liver microsomes and hepatocytes not only confirmed the formation of 2-oxo-3-HO-LSD but also identified a 2,3-dihydroxy-LSD metabolite (60).
HO-LSD Binding (formation) of in hepatocytes
5) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0 Pain Relevance 0
LSD was thought initially to act through 5-HT antagonism in the central nervous system or through mimicry of 5-HT actions by interacting with the 5-HT receptor.
LSD Binding (interacting) of in central nervous system associated with central nervous system
6) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0.64 Pain Relevance 0.36
HSA is a heart-shaped protein composed of three homologous helical domains (I-III), which can be subdivided into two subdomains (A and B), and lidocaine binds to a unique site formed by residues from subdomain IB facing the central, interdomain crevice.
I-III Binding (binds) of in heart associated with lidocaine
7) Confidence 0.09 Published 2010 Journal J. Struct. Biol. Section Abstract Doc Link 20347991 Disease Relevance 0 Pain Relevance 0.52
I have experimented with LSD, psilocybin, amphetamines but not currently using any of these.
LSD Binding (experimented) of
8) Confidence 0.04 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1939993 Disease Relevance 0.52 Pain Relevance 0.53
Drugs interacting with other receptors, such as LSD, failed to exhibit protracted exacerbations (see [37, 38] and references therein).
LSD Binding (interacting) of
9) Confidence 0.01 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2825652 Disease Relevance 0.22 Pain Relevance 0.06

General Comments

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