INT65954

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.78
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
striatum 6
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 2 99.30 Very High Very High Very High
Nucleus accumbens 1 94.40 High High
Neuropeptide 3 87.76 High High
Deafferentation 2 86.24 High High
agonist 1 80.24 Quite High
antagonist 4 79.84 Quite High
Serotonin 4 75.00 Quite High
Glutamate receptor 1 70.16 Quite High
Eae 2 36.00 Quite Low
nMDA receptor 1 33.20 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 9 91.68 High High
Dyskinesias 8 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine if increased PPT and PPE mRNA levels represented a transient response to brief 5-HT inhibition, additional experiments were performed to provide continual suppression of 5-HT within the striatum.
Spec (determine) Positive_regulation (increased) of Transcription (levels) of PPT in striatum
1) Confidence 0.43 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.20
Treadmill running induced a significant increase in the levels of both PPT (60% increase) and PPE (90% increase) mRNA in the striatum of normal rats.
Positive_regulation (increase) of Transcription (levels) of PPT in striatum
2) Confidence 0.34 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10381545 Disease Relevance 0 Pain Relevance 0.26
Using in situ hybridisation histochemistry, we now compare the effects of these drug treatments on striatal preproenkephalin-A (PPE-A) and adenosine A(2a) receptor mRNA expression as markers of the indirect pathway and striatal preprotachykinin (PPT) mRNA and preproenkephalin-B (PPE-B, prodynorphin) mRNA expression as markers of the direct pathway.The equivalent marked losses of specific [3H]mazindol binding in the striatum of all drug treatment groups confirmed the identical nature of the nigral cell loss produced by MPTP treatment.
Positive_regulation (markers) of Transcription (expression) of PPT in striatum associated with parkinson's disease and adenocard
3) Confidence 0.09 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453478 Disease Relevance 0.78 Pain Relevance 0.09

General Comments

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