INT65959

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 75
Total Number 79
Disease Relevance 77.30
Pain Relevance 8.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
B cells 6
T-cell 6
endometrium 4
lymphocyte 4
macrophages 2
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 157 99.92 Very High Very High Very High
Dismenorea 20 99.82 Very High Very High Very High
endometriosis 36 99.56 Very High Very High Very High
dexamethasone 148 99.36 Very High Very High Very High
cINOD 44 99.36 Very High Very High Very High
Morphine 10 99.30 Very High Very High Very High
agonist 38 98.56 Very High Very High Very High
Buprenorphine 2 97.96 Very High Very High Very High
metalloproteinase 19 97.04 Very High Very High Very High
opioid receptor 1 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 2490 100.00 Very High Very High Very High
Endometriosis 68 100.00 Very High Very High Very High
Repression 36 100.00 Very High Very High Very High
Cancer 1629 99.96 Very High Very High Very High
Metastasis 212 99.90 Very High Very High Very High
Colon Cancer 135 99.86 Very High Very High Very High
Lymphatic System Cancer 105 99.72 Very High Very High Very High
Targeted Disruption 38 99.68 Very High Very High Very High
Colorectal Cancer 8 99.66 Very High Very High Very High
Eosinophilic Esophagitis 106 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stromal bcl-2 expression in endometriotic foci was significantly increased compared with the paired eutopic endometrium, did not vary with menstrual cycle and included a significant population of non-leukocytic bcl-2+ stromal cells.
Positive_regulation (increased) of Gene_expression (expression) of bcl-2 in stromal cells associated with endometriosis
1) Confidence 0.70 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 1.13 Pain Relevance 0.35
Stromal bcl-2 expression increased in the late secretory phase in control and eutopic endometrium in endometriosis; double labelling studies revealed that most stromal bcl-2+ cells were leukocytes.
Positive_regulation (increased) of Gene_expression (expression) of bcl-2 in endometrium associated with endometriosis
2) Confidence 0.70 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 1.10 Pain Relevance 0.35
Elevated stromal bcl-2 expression in ovarian endometriotic lesions could have implications for the growth and survival of ectopic endometrial tissue at these sites.
Positive_regulation (Elevated) of Gene_expression (expression) of bcl-2 associated with endometriosis
3) Confidence 0.70 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 0.79 Pain Relevance 0.31
Glandular epithelial bcl-2 expression also varied with menstrual cycle phase and peaked in the proliferative phase; in contrast, surface epithelial bcl-2 expression increased in the late secretory phase.
Positive_regulation (increased) of Gene_expression (expression) of bcl-2
4) Confidence 0.70 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 0.80 Pain Relevance 0.32
Freshly isolated hepatocytes perfused into the RFB showed a progressive increase of MEGX while a loss in Bax expression was paralleled by an increase in Bcl-2 expression, in comparison to starting hepatocytes.
Positive_regulation (increase) of Gene_expression (expression) of Bcl-2 in hepatocytes associated with apoptosis
5) Confidence 0.63 Published 2003 Journal Int J Artif Organs Section Abstract Doc Link 12653348 Disease Relevance 0.64 Pain Relevance 0.08
We showed that pro-apoptotic BCL2-interacting killer gene (BIK/NBK) overexpressed in nearly all samples (14/15), which makes it a possible candidate for further studies on its role in breast cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of BCL2 associated with breast cancer and apoptosis
6) Confidence 0.62 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.04 Pain Relevance 0.04
Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 in cleavage
7) Confidence 0.55 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.91 Pain Relevance 0.13
Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Bcl-2 in colon associated with colon cancer and apoptosis
8) Confidence 0.55 Published 2005 Journal Mol. Cancer Ther. Section Title Doc Link 16227396 Disease Relevance 1.24 Pain Relevance 0.20
Inasmuch as Bcl-2 suppresses while Bax accelerates apoptosis, treatment of cells with morphine reduced the expression of Bax and enhanced the expression of Bcl-2.
Positive_regulation (enhanced) of Gene_expression (expression) of Bcl-2 associated with apoptosis and morphine
9) Confidence 0.53 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12927789 Disease Relevance 0.86 Pain Relevance 0.85
Their absence in endometriotic lesions together with increased CD+8 T-cell numbers and increased oestrogen receptor and bcl-2 expression may have significant effects on the development and progression of endometriosis.
Positive_regulation (increased) of Gene_expression (expression) of bcl-2 in T-cell associated with endometriosis
10) Confidence 0.52 Published 1998 Journal Hum. Reprod. Update Section Abstract Doc Link 10027623 Disease Relevance 0.51 Pain Relevance 0.21
Derivatives of LNCaP cells that stably overexpress bcl-2 remained sensitive to growth inhibition and induction of apoptosis by these compounds.
Positive_regulation (overexpress) of Gene_expression (overexpress) of bcl-2 associated with apoptosis
11) Confidence 0.51 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10484067 Disease Relevance 0.89 Pain Relevance 0.11
Therefore, sulindac derivatives can cause growth inhibition and induce apoptosis in human prostate cancer cells by a COX-1 and -2 independent mechanism, and this occurs irrespective of androgen sensitivity or increased expression of bcl-2.
Positive_regulation (increased) of Gene_expression (expression) of bcl-2 associated with apoptosis and reprotox - general 1
12) Confidence 0.51 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10484067 Disease Relevance 0.79 Pain Relevance 0.04
Over-expressed Bcl-2 cannot suppress apoptosis via the mitochondria in buprenorphine hydrochloride-treated NG108-15 cells.
Positive_regulation (Over-expressed) of Gene_expression (expressed) of Bcl-2 in NG108-15 associated with apoptosis and buprenorphine
13) Confidence 0.50 Published 2004 Journal Biol. Pharm. Bull. Section Title Doc Link 15340216 Disease Relevance 0.92 Pain Relevance 0.29
To study the role of DC immune in LPS-induced sepsis, a transgenic mouse model with DCs overexpressing a human form of anti-apoptotic protein Bcl-2 (DC-hBcl-2 mice) has been used [28].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Bcl-2 in DCs associated with targeted disruption, apoptosis and sepsis
14) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2902015 Disease Relevance 1.15 Pain Relevance 0.09
to bind to p53 in order to stabilize it, and also activates the expression of various genes including Bax (a proapoptotic member of the Bcl-2 family) [25].
Positive_regulation (activates) of Gene_expression (expression) of Bcl-2
15) Confidence 0.49 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2975073 Disease Relevance 1.22 Pain Relevance 0.13
Overexpression of anti-apoptotic proteins including Bcl-2 family members and AKT/PKB pathway agonists have been found in a variety of human cancers including pancreas[25], breast[26], prostate [27] and lung[28].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Bcl-2 in lung associated with cancer, agonist and apoptosis
16) Confidence 0.49 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 1.22 Pain Relevance 0.05
Although the mechanism for activating the expression and function of Bcl-2, Bcl-XL and Bax is not fully understood, it is possible that the p53 molecule plays a role in this process [30].
Positive_regulation (activating) of Gene_expression (expression) of Bcl-2
17) Confidence 0.48 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 0.99 Pain Relevance 0.11
Furthermore, recent evidence indicates that an apoptotic block through p53 mutations or bcl-2 overexpression may have a potential role in the poor responses seen with standard chemotherapy.
Positive_regulation (overexpression) of Gene_expression (overexpression) of bcl-2 associated with apoptosis
18) Confidence 0.47 Published 1999 Journal Cancer Invest. Section Abstract Doc Link 10071598 Disease Relevance 0.70 Pain Relevance 0.09
In the presence of bcl-2 overexpression, the ability of the cell to remove genetic and cell damage through apoptosis is limited.
Positive_regulation (overexpression) of Gene_expression (overexpression) of bcl-2 associated with apoptosis
19) Confidence 0.46 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 1.39 Pain Relevance 0
Grover et al. [11] have reported a lower survival rate in CM patients with regional lymph node metastasis and positive bcl-2 expression.
Positive_regulation (positive) of Gene_expression (expression) of bcl-2 in lymph node associated with skin cancer and metastasis
20) Confidence 0.46 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 1.27 Pain Relevance 0

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