INT65960

Context Info Confidence 0.78 First Reported 1996 Last Reported 2011 Negated 11 Speculated 7 Reported most in Abstract Documents 352 Total Number 359 Disease Relevance 312.03 Pain Relevance 30.73

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2) intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)

Anatomy Link Frequency endometrium 6 visceral 6 B-cell 6 T cell 6 colon 5 BCL2 (Homo sapiens)

Pain Link Frequency Relevance Heat Dismenorea 57 99.92 agonist 241 99.84 COX-2 inhibitor 364 99.70 cytokine 513 99.60 aspirin 80 99.44 Potency 48 99.40 cINOD 244 99.36 dexamethasone 884 99.32 Dynorphin 10 99.12 Morphine 51 99.08

Disease Link Frequency Relevance Heat Apoptosis 9747 100.00 Cancer 7975 100.00 Breast Cancer 1547 100.00 Lymphatic System Cancer 592 100.00 Pancreatic Cancer 377 100.00 Melanoma 269 100.00 Endometriosis 201 100.00 Hyperoxia 110 100.00 Repression 81 100.00 Retinoblastoma 43 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Bcl-2 was negative in almost all samples from ovarian endometriosis, whereas it was positive in all adenomyotic tissues from cases in the proliferative phase, but in none of tissues from cases in the secretory phase.

Neg (negative) Gene_expression (negative) of Bcl-2 associated with endometriosis and dismenorea

1) Confidence 0.78 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9267815 Disease Relevance 1.37 Pain Relevance 0.51

RESULTS: After 16 h of dynorphin (10 microM) treatment, the SH-SY5Y cells showed significant cytotoxicity, apoptosis, and downregulation of the antiapoptotic Bcl-2 protein expression.

Gene_expression (expression) of Bcl-2 in SH-SY5Y

2) Confidence 0.78 Published 2009 Journal Acta Anaesthesiol Scand Section Body Doc Link 19032555 Disease Relevance 0.07 Pain Relevance 0

Isoflurane attenuates dynorphin-induced cytotoxicity and downregulation of Bcl-2 expression in differentiated neuroblastoma SH-SY5Y cells.

Gene_expression (expression) of Bcl-2 in SH-SY5Y associated with neuroblastoma, dynorphin and isoflurane

3) Confidence 0.78 Published 2009 Journal Acta Anaesthesiol Scand Section Title Doc Link 19032555 Disease Relevance 0.10 Pain Relevance 0.46

In contrast, stromal bcl-2 expression in adenomyosis remained at low levels and did not show significant cyclical variation.

Gene_expression (expression) of bcl-2 associated with dismenorea

4) Confidence 0.78 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 1.06 Pain Relevance 0.35

Stromal bcl-2 expression in endometriotic foci was significantly increased compared with the paired eutopic endometrium, did not vary with menstrual cycle and included a significant population of non-leukocytic bcl-2+ stromal cells.

Gene_expression (expression) of bcl-2 in stromal cells associated with endometriosis

5) Confidence 0.78 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 1.12 Pain Relevance 0.35

Stromal bcl-2 expression increased in the late secretory phase in control and eutopic endometrium in endometriosis; double labelling studies revealed that most stromal bcl-2+ cells were leukocytes.

Gene_expression (expression) of bcl-2 in endometrium associated with endometriosis

6) Confidence 0.78 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 1.10 Pain Relevance 0.35

Elevated stromal bcl-2 expression in ovarian endometriotic lesions could have implications for the growth and survival of ectopic endometrial tissue at these sites.

Gene_expression (expression) of bcl-2 associated with endometriosis

7) Confidence 0.78 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 0.73 Pain Relevance 0.29

Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis.

Gene_expression (expression) of bcl-2 in endometrium associated with endometriosis, dismenorea and apoptosis

8) Confidence 0.78 Published 1998 Journal Hum. Reprod. Section Title Doc Link 9886539 Disease Relevance 1.12 Pain Relevance 0.31

Apoptosis and bcl-2 expression were examined in paired eutopic and ectopic endometrium from women with endometriosis (n = 30 samples) or adenomyosis (n = 15 samples) and compared with control endometrium (n = 30 samples).

Gene_expression (expression) of bcl-2 in endometrium associated with endometriosis, dismenorea and apoptosis

9) Confidence 0.78 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 0.96 Pain Relevance 0.26

Apoptotic cells were detected using the dUTP nick-end labelling (TUNEL) assay for DNA fragmentation; bcl-2 expression was demonstrated with a streptavidin-biotin peroxidase immunohistochemical technique.

Gene_expression (expression) of bcl-2 in Apoptotic cells associated with apoptosis

10) Confidence 0.78 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 1.07 Pain Relevance 0.29

Glandular epithelial bcl-2 expression also varied with menstrual cycle phase and peaked in the proliferative phase; in contrast, surface epithelial bcl-2 expression increased in the late secretory phase.

Gene_expression (expression) of bcl-2

11) Confidence 0.78 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 0.80 Pain Relevance 0.32

By using Western blotting methods, capsaicin reduced the expression of Bcl-2, the antiapoptotic protein, in AGS cells in a concentration-dependent manner.

Gene_expression (expression) of Bcl-2 in AGS

12) Confidence 0.78 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 16419151 Disease Relevance 0.18 Pain Relevance 0

Although the apoptotic events tested were identical in the parental cells and transformants, Bcl-2 expression completely failed to inhibit Bph-induced apoptosis in the Bcl-2(P2) cells.

Gene_expression (expression) of Bcl-2 associated with benign prostatic hypertrophy and apoptosis

13) Confidence 0.77 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15340216 Disease Relevance 1.11 Pain Relevance 0.19

We made an NG108-15 transfectant, Bcl-2(P2), that stably expressed human Bcl-2, and used it to test Bcl-2's effect on the serum-starvation-induced apoptosis in NG108-15 cells.

Gene_expression (expressed) of Bcl-2 in NG108-15 associated with starvation and apoptosis

14) Confidence 0.77 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15340216 Disease Relevance 1.04 Pain Relevance 0.22

Over-expressed Bcl-2 cannot suppress apoptosis via the mitochondria in buprenorphine hydrochloride-treated NG108-15 cells.

Gene_expression (expressed) of Bcl-2 in NG108-15 associated with apoptosis and buprenorphine

15) Confidence 0.77 Published 2004 Journal Biol. Pharm. Bull. Section Title Doc Link 15340216 Disease Relevance 0.92 Pain Relevance 0.29

Nevertheless, bcl-2 expression in our study was similar to that described in previous studies employing immunohistochemical methods [14,15,32,33].

Gene_expression (expression) of bcl-2

16) Confidence 0.76 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 0.92 Pain Relevance 0

Univariate and multivariate Cox regression tests were performed to evaluate the interaction between gender, age at first metastasis, survival, type of metastasis, and bcl-2 expression.

Gene_expression (expression) of bcl-2 associated with metastasis

17) Confidence 0.76 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 0.78 Pain Relevance 0.04

The purpose of the present study was to evaluate the relationship between the immunohistochemical expression of bcl-2 and survival in patients with regional lymph node, subcutaneous and visceral metastases of CM.

Gene_expression (expression) of bcl-2 in visceral associated with skin cancer and metastasis

18) Confidence 0.76 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 1.33 Pain Relevance 0

In addition, the expression of bcl-2 in CM metastases was evaluated without comparison to bcl-2 expression in normal melanocytes.

Gene_expression (expression) of bcl-2 in melanocytes associated with skin cancer and metastasis

19) Confidence 0.76 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 0.99 Pain Relevance 0

Several different tissues express the bcl-2 protein.

Gene_expression (express) of bcl-2

20) Confidence 0.76 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 1.84 Pain Relevance 0

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