INT65960
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Bcl-2 was negative in almost all samples from ovarian endometriosis, whereas it was positive in all adenomyotic tissues from cases in the proliferative phase, but in none of tissues from cases in the secretory phase. | |||||||||||||||
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RESULTS: After 16 h of dynorphin (10 microM) treatment, the SH-SY5Y cells showed significant cytotoxicity, apoptosis, and downregulation of the antiapoptotic Bcl-2 protein expression. | |||||||||||||||
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Isoflurane attenuates dynorphin-induced cytotoxicity and downregulation of Bcl-2 expression in differentiated neuroblastoma SH-SY5Y cells. | |||||||||||||||
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In contrast, stromal bcl-2 expression in adenomyosis remained at low levels and did not show significant cyclical variation. | |||||||||||||||
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Stromal bcl-2 expression in endometriotic foci was significantly increased compared with the paired eutopic endometrium, did not vary with menstrual cycle and included a significant population of non-leukocytic bcl-2+ stromal cells. | |||||||||||||||
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Stromal bcl-2 expression increased in the late secretory phase in control and eutopic endometrium in endometriosis; double labelling studies revealed that most stromal bcl-2+ cells were leukocytes. | |||||||||||||||
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Elevated stromal bcl-2 expression in ovarian endometriotic lesions could have implications for the growth and survival of ectopic endometrial tissue at these sites. | |||||||||||||||
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Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis. | |||||||||||||||
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Apoptosis and bcl-2 expression were examined in paired eutopic and ectopic endometrium from women with endometriosis (n = 30 samples) or adenomyosis (n = 15 samples) and compared with control endometrium (n = 30 samples). | |||||||||||||||
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Apoptotic cells were detected using the dUTP nick-end labelling (TUNEL) assay for DNA fragmentation; bcl-2 expression was demonstrated with a streptavidin-biotin peroxidase immunohistochemical technique. | |||||||||||||||
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Glandular epithelial bcl-2 expression also varied with menstrual cycle phase and peaked in the proliferative phase; in contrast, surface epithelial bcl-2 expression increased in the late secretory phase. | |||||||||||||||
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By using Western blotting methods, capsaicin reduced the expression of Bcl-2, the antiapoptotic protein, in AGS cells in a concentration-dependent manner. | |||||||||||||||
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Although the apoptotic events tested were identical in the parental cells and transformants, Bcl-2 expression completely failed to inhibit Bph-induced apoptosis in the Bcl-2(P2) cells. | |||||||||||||||
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We made an NG108-15 transfectant, Bcl-2(P2), that stably expressed human Bcl-2, and used it to test Bcl-2's effect on the serum-starvation-induced apoptosis in NG108-15 cells. | |||||||||||||||
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Over-expressed Bcl-2 cannot suppress apoptosis via the mitochondria in buprenorphine hydrochloride-treated NG108-15 cells. | |||||||||||||||
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Nevertheless, bcl-2 expression in our study was similar to that described in previous studies employing immunohistochemical methods [14,15,32,33]. | |||||||||||||||
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Univariate and multivariate Cox regression tests were performed to evaluate the interaction between gender, age at first metastasis, survival, type of metastasis, and bcl-2 expression. | |||||||||||||||
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The purpose of the present study was to evaluate the relationship between the immunohistochemical expression of bcl-2 and survival in patients with regional lymph node, subcutaneous and visceral metastases of CM.
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In addition, the expression of bcl-2 in CM metastases was evaluated without comparison to bcl-2 expression in normal melanocytes. | |||||||||||||||
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Several different tissues express the bcl-2 protein. | |||||||||||||||
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