INT65965

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 52
Total Number 57
Disease Relevance 22.53
Pain Relevance 13.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adcyap1) extracellular space (Adcyap1) extracellular region (Adcyap1)
Anatomy Link Frequency
neurons 6
pituitary 4
retinal ganglion cells 4
retina 3
nervous system 2
Adcyap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 236 100.00 Very High Very High Very High
cytokine 42 100.00 Very High Very High Very High
Inflammatory mediators 21 100.00 Very High Very High Very High
Ventral tegmentum 1 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
intrathecal 20 99.98 Very High Very High Very High
Glutamate 324 99.76 Very High Very High Very High
Central nervous system 251 99.68 Very High Very High Very High
Spinal cord 85 99.68 Very High Very High Very High
substance P 26 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 222 100.00 Very High Very High Very High
Ganglion Cysts 138 100.00 Very High Very High Very High
Targeted Disruption 35 99.78 Very High Very High Very High
Male Infertility 1 99.72 Very High Very High Very High
Disease 236 99.48 Very High Very High Very High
Nociception 53 99.48 Very High Very High Very High
Pancreatitis 24 99.30 Very High Very High Very High
Autoimmune Disease 159 99.12 Very High Very High Very High
Fatigue 113 99.12 Very High Very High Very High
Pain 27 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pituitary adenylate cyclase-activating polypeptide (PACAP) is exclusively coexpressed with melanopsin in a small subset of retinal ganglion cells and is predicted to be involved extensively in these responses; however, there were inconsistencies in the previous reports, and its functional role has not been well understood.


Gene_expression (coexpressed) of PACAP in retinal ganglion cells associated with ganglion cysts
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2823792 Disease Relevance 0.30 Pain Relevance 0
Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice.
Gene_expression (Over-expression) of PACAP in pituitary associated with pancreatitis and cytokine
2) Confidence 0.76 Published 2009 Journal J. Pharmacol. Sci. Section Title Doc Link 19672038 Disease Relevance 0.79 Pain Relevance 0.26
To investigate the role of pancreatic PACAP in the development of acute pancreatitis, we employed transgenic mice over-expressing PACAP in pancreatic beta-cells (PACAP-Tg).
Gene_expression (expressing) of PACAP associated with targeted disruption and pancreatitis
3) Confidence 0.76 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.82 Pain Relevance 0.20
In particular, PACAP stimulates catecholamine biosynthesis as well as the expression of various genes, including chromogranin A, neuropeptide Y, enkephalins, vasoactive intestinal polypeptide, and PACAP itself.
Gene_expression (expression) of PACAP associated with catecholamine, neuropeptide and enkephalin
4) Confidence 0.74 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12438165 Disease Relevance 0.17 Pain Relevance 0.25
RATIONALE: The neuropeptide pituitary adenylyl cyclase-activating peptide (PACAP) and its receptors (PAC1 and VPAC2) are expressed in the ventral tegmental area and nucleus accumbens, raising the possibility that PACAP could be a potential modulator of the mesolimbic dopaminergic system.
Gene_expression (expressed) of PACAP in nucleus accumbens associated with nucleus accumbens, ventral tegmentum and neuropeptide
5) Confidence 0.72 Published 2009 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 19199096 Disease Relevance 0 Pain Relevance 0.22
Pituitary adenylate cyclase-activating polypeptide (PACAP) is exclusively coexpressed with melanopsin in a small subset of retinal ganglion cells and is predicted to be involved extensively in these responses; however, there were inconsistencies in the previous reports, and its functional role has not been well understood.


Gene_expression (coexpressed) of cyclase-activating polypeptide in retinal ganglion cells associated with ganglion cysts
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2823792 Disease Relevance 0.30 Pain Relevance 0
Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-).
Neg (lacking) Gene_expression (lacking) of PACAP
7) Confidence 0.68 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 16888223 Disease Relevance 0 Pain Relevance 0.20
Similar to substance P, these behaviors produced by PACAP can be considered as pain-like syndrome.
Gene_expression (produced) of PACAP associated with pain, syndrome and substance p
8) Confidence 0.68 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8891591 Disease Relevance 0.42 Pain Relevance 0.56
In conclusion, our results suggest that PACAP controls smooth muscle contractility, acting directly on the muscle cells through PACAP-27 preferring receptors coupled to apamin-sensitive Ca2+-dependent K+-channels and indirectly through the stimulation of NO production.
Gene_expression (acting) of PACAP in muscle cells
9) Confidence 0.67 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975700 Disease Relevance 0 Pain Relevance 0.24
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and implicated in neurotransmission, neural plasticity, and neurotrophic actions.
Gene_expression (distributed) of neuropeptide pituitary adenylate cyclase-activating polypeptide in nervous system associated with neuropeptide
10) Confidence 0.67 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15317855 Disease Relevance 0.66 Pain Relevance 0.67
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and implicated in neurotransmission, neural plasticity, and neurotrophic actions.
Gene_expression (distributed) of PACAP in nervous system associated with neuropeptide
11) Confidence 0.67 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15317855 Disease Relevance 0.66 Pain Relevance 0.66
Although PACAP is distributed in the spinal cord and dorsal root ganglia, a role of PACAP in pain responses remains essentially unknown.
Gene_expression (distributed) of PACAP in dorsal root ganglia associated with pain and spinal cord
12) Confidence 0.67 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15317855 Disease Relevance 0.71 Pain Relevance 0.75
Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice.
Gene_expression (Over-expression) of pituitary adenylate cyclase-activating polypeptide in pituitary associated with pancreatitis and cytokine
13) Confidence 0.66 Published 2009 Journal J. Pharmacol. Sci. Section Title Doc Link 19672038 Disease Relevance 0.79 Pain Relevance 0.26
Pituitary adenylate cyclase-activating polypeptide (PACAP) immunoreactive neural elements have been detected in the mouse spinal cord.
Gene_expression (detected) of PACAP in Pituitary associated with spinal cord
14) Confidence 0.60 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15518901 Disease Relevance 0.24 Pain Relevance 0.40
mice could be also related to melanopsin-mediated phototransduction, because melanopsin is a photoreceptor that is exclusively colocalized in PACAP-expressing ganglion cells in the retina [13], and because melanopsin is suggested to dominantly mediate the transduction of photic information for negative masking [21], [30].
Gene_expression (expressing) of PACAP in retina associated with ganglion cysts
15) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823792 Disease Relevance 0.10 Pain Relevance 0
In the retina, PACAP is exclusively expressed with melanopsin [13] in a small subset of retinal ganglion cells [14], [15].
Gene_expression (expressed) of PACAP in retinal ganglion cells associated with ganglion cysts
16) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823792 Disease Relevance 0.17 Pain Relevance 0.08
Thus, we examined whether there was any remodeling in terms of morphology, neuronal projections and PACAP-related gene expression, in the retinas of Adcyap1?
Gene_expression (expression) of PACAP-related gene in retinas
17) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823792 Disease Relevance 0.14 Pain Relevance 0.03
mice could be also related to melanopsin-mediated phototransduction, because melanopsin is a photoreceptor that is exclusively colocalized in PACAP-expressing ganglion cells in the retina [13], and because melanopsin is suggested to dominantly mediate the transduction of photic information for negative masking [21], [30].
Gene_expression (-) of PACAP in retina associated with ganglion cysts
18) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823792 Disease Relevance 0.10 Pain Relevance 0
Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-).
Neg (lacking) Gene_expression (lacking) of Adcyap1
19) Confidence 0.59 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 16888223 Disease Relevance 0 Pain Relevance 0.20
In the early phase, PACAP produced an increase of tail flick latency.
Gene_expression (produced) of PACAP in tail associated with tail-flick
20) Confidence 0.59 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15518901 Disease Relevance 0.39 Pain Relevance 0.77

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