INT6598

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Context Info
Confidence 0.46
First Reported 1992
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 4.88
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA2) plasma membrane (ITGA2)
Anatomy Link Frequency
pancreas 1
acinar cells 1
extracellular matrix 1
T cells 1
ITGA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 16 95.62 Very High Very High Very High
Chronic pancreatitis 3 95.44 Very High Very High Very High
Enkephalin 1 85.24 High High
cytokine 24 81.64 Quite High
Opioid 2 80.32 Quite High
endometriosis 11 75.40 Quite High
Dismenorea 10 50.00 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 25 100.00 Very High Very High Very High
Pancreatic Cancer 30 98.76 Very High Very High Very High
Cancer 11 97.52 Very High Very High Very High
Interstitial Cystitis 16 95.62 Very High Very High Very High
Pancreatitis 3 95.44 Very High Very High Very High
Metastasis 3 93.20 High High
Dysmenorrhea 10 86.60 High High
Endometriosis (extended) 11 86.00 High High
Prostate Cancer 2 82.96 Quite High
Pressure And Volume Under Development 1 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BrU and DADLE molecules were detected by immunogold techniques and the labeling was quantitatively evaluated.
Gene_expression (detected) of BrU
1) Confidence 0.46 Published 2004 Journal Microsc. Res. Tech. Section Abstract Doc Link 15452891 Disease Relevance 0.16 Pain Relevance 0.24
The expression of the VLA-integrins alpha 2, alpha 3, alpha 5 and alpha 6 was studied immunohistochemically in tissue samples from ductal pancreatic cancer, chronic pancreatitis, normal pancreas and in 8 cell lines of ductal human pancreatic cancer.
Gene_expression (expression) of VLA-integrins alpha 2 in pancreas associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.41 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 0.51 Pain Relevance 0.10
Immunohistochemically, VLA alpha 2 and VLA alpha 6 were moderately to strongly expressed on the basal surface of ductal and acinar cells in normal pancreatic tissue, while centro-acinar cells predominantly expressed VLA alpha 3 and VLA alpha 5.
Gene_expression (expressed) of VLA alpha 2 in acinar cells
3) Confidence 0.41 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 0.81 Pain Relevance 0.09
The redistribution of VLA alpha 2 and VLA alpha 6 may reflect a loss of spatial arrangement of tumor cells and their ability to interact randomly with extracellular matrix structures during invasion and metastasis.
Gene_expression (redistribution) of VLA alpha 2 in extracellular matrix associated with cancer and metastasis
4) Confidence 0.36 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 1.14 Pain Relevance 0.07
The samples were immunohistochemically examined for the expression of very late activation antigen-2 (VLA-2), VLA-3, VLA-4, VLA-5, VLA-6, and E-cadherin.
Spec (examined) Gene_expression (expression) of VLA-4
5) Confidence 0.12 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Body Doc Link 9392916 Disease Relevance 0.17 Pain Relevance 0
The samples were immunohistochemically examined for the expression of very late activation antigen-2 (VLA-2), VLA-3, VLA-4, VLA-5, VLA-6, and E-cadherin.
Spec (examined) Gene_expression (expression) of late activation antigen-2
6) Confidence 0.12 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Body Doc Link 9392916 Disease Relevance 0.17 Pain Relevance 0
In contrast, the expression of VLA-4 in the adenomyosis group was significantly reduced in the secretory phase.
Gene_expression (expression) of VLA-4
7) Confidence 0.12 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Body Doc Link 9392916 Disease Relevance 0.15 Pain Relevance 0
The samples were immunohistochemically examined for the expression of very late activation antigen-2 (VLA-2), VLA-3, VLA-4, VLA-5, VLA-6, and E-cadherin.
Spec (examined) Gene_expression (expression) of VLA-2
8) Confidence 0.12 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Body Doc Link 9392916 Disease Relevance 0.17 Pain Relevance 0
RESULTS: The expression of each VLA molecule and E-cadherin except VLA-4, VLA-5, and VLA-6 was significantly increased throughout the menstrual cycle in endometria in both the endometriosis and adenomyosis groups.
Gene_expression (expression) of VLA-4
9) Confidence 0.09 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Body Doc Link 9392916 Disease Relevance 0.16 Pain Relevance 0
In addition, leptin promotes the expression of adhesion molecules in CD4+ T cells, such as VLA-2 (CD49b) or ICAM-1 (CD54) [5, 18].
Gene_expression (expression) of VLA-2 in T cells associated with adhesions
10) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.29 Pain Relevance 0.08
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Gene_expression (expression) of alpha2-integrin associated with interstitial cystitis
11) Confidence 0.04 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.57 Pain Relevance 0.57
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Gene_expression (expression) of alpha2-integrin associated with interstitial cystitis
12) Confidence 0.04 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.57 Pain Relevance 0.57

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