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Context Info
Confidence 0.32
First Reported 1996
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.05
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) aging (IL1B) endoplasmic reticulum (PTGS2)
enzyme binding (PTGS2) protein complex (PTGS2) cytoplasm (PTGS2)
Anatomy Link Frequency
astrocytes 1
IL1B (Homo sapiens)
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 8 100.00 Very High Very High Very High
Inflammatory mediators 1 99.56 Very High Very High Very High
cOX1 1 96.36 Very High Very High Very High
Inflammation 3 93.28 High High
cINOD 2 89.04 High High
metalloproteinase 4 88.36 High High
Pain 1 85.60 High High
cytokine 5 83.96 Quite High
Inflammatory response 1 68.68 Quite High
Lasting pain 1 55.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.56 Very High Very High Very High
Neuroblastoma 3 98.28 Very High Very High Very High
Disease 13 92.08 High High
Gliosis 1 88.24 High High
Fever 1 87.64 High High
Pain 2 85.60 High High
Injury 2 62.88 Quite High
Hemorrhage 1 56.64 Quite High
Cumulative Trauma Disorders 1 53.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 beta (1 nM) induced mRNAs for cyclooxygenase 2 (COX2), MMP-1, -3, -13 and aggrecanase-1 as well as IL-1 beta and IL-6, whereas mRNAs for COX1 and MMP-2 were expressed constitutively.
IL-1 Positive_regulation (induced) of cyclooxygenase 2 associated with cox2 and cox1
1) Confidence 0.32 Published 2003 Journal J. Orthop. Res. Section Abstract Doc Link 12568957 Disease Relevance 0.56 Pain Relevance 0.65
Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB.
Interleukin-1beta Positive_regulation (induces) of cyclooxygenase-2 associated with neuroblastoma and cox2
2) Confidence 0.25 Published 2000 Journal J. Neurochem. Section Title Doc Link 11032891 Disease Relevance 0.50 Pain Relevance 0.17
We have previously shown that PGHS-2 message is induced by Interleukin-1 beta and other inflammatory mediators in primary cultures of rodent astrocytes.
Interleukin-1 beta Positive_regulation (induced) of PGHS-2 in astrocytes associated with inflammatory mediators
3) Confidence 0.21 Published 1996 Journal Neurobiol. Aging Section Abstract Doc Link 8892355 Disease Relevance 0.99 Pain Relevance 0.21

General Comments

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