INT6599

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Context Info
Confidence 0.35
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.60
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA2) plasma membrane (ITGA2)
Anatomy Link Frequency
spinal 1
platelet 1
extracellular matrix 1
ITGA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 3 100.00 Very High Very High Very High
epidural 3 99.80 Very High Very High Very High
backache 2 99.22 Very High Very High Very High
cva 2 97.28 Very High Very High Very High
Inflammation 9 86.96 High High
antagonist 1 84.80 Quite High
Angina 2 80.88 Quite High
Chronic pancreatitis 2 78.64 Quite High
Osteoarthritis 64 77.28 Quite High
cytokine 3 47.40 Quite Low
Disease Link Frequency Relevance Heat
Cancer 7 100.00 Very High Very High Very High
Spinal Epidural Hematoma 2 99.98 Very High Very High Very High
Pancreatic Cancer 20 99.68 Very High Very High Very High
Low Back Pain 2 99.22 Very High Very High Very High
Metastasis 2 97.32 Very High Very High Very High
Hemorrhage 1 95.36 Very High Very High Very High
Apoptosis 11 88.32 High High
INFLAMMATION 11 86.96 High High
Adhesions 14 82.40 Quite High
Pancreatitis 2 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evaluation of back pain secondary to spinal epidural hematoma associated with aspirin intake and a partial platelet glycoprotein Ia/IIa deficiency.
platelet glycoprotein Spec (partial) Binding (associated) of in spinal associated with aspirin, spinal epidural hematoma, epidural and backache
1) Confidence 0.35 Published 1994 Journal Arch. Intern. Med. Section Title Doc Link 7993163 Disease Relevance 0.48 Pain Relevance 0.57
Moreover, integrin alpha 2 (ITGA2) is associated with caveolin-1 in tumor cells [38].
ITGA2 Binding (associated) of associated with cancer
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.80 Pain Relevance 0.24
Pancreatic carcinoma showed intense staining for VLA alpha 2 and VLA alpha 6 with a diffuse distribution on the cell surface.
VLA alpha 2 Binding (staining) of associated with pancreatic cancer
3) Confidence 0.20 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 1.00 Pain Relevance 0.08
The redistribution of VLA alpha 2 and VLA alpha 6 may reflect a loss of spatial arrangement of tumor cells and their ability to interact randomly with extracellular matrix structures during invasion and metastasis.
VLA alpha 2 Binding (interact) of in extracellular matrix associated with cancer and metastasis
4) Confidence 0.20 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 1.25 Pain Relevance 0.07
BACKGROUND: Ligand binding to the platelet membrane receptor glycoprotein (GP) IIb/IIIa, the final and obligatory step to platelet aggregation, can now be inhibited by pharmacological agents.
platelet membrane receptor glycoprotein Binding (binding) of in platelet
5) Confidence 0.07 Published 1996 Journal Circulation Section Abstract Doc Link 8790023 Disease Relevance 0.07 Pain Relevance 0.20

General Comments

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