INT65994

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Context Info
Confidence 0.53
First Reported 1996
Last Reported 2007
Negated 4
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.38
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD7)
Anatomy Link Frequency
T cells 5
bone marrow 2
CD7 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 200 98.22 Very High Very High Very High
rheumatoid arthritis 24 89.52 High High
Pain 3 82.36 Quite High
palliative 1 80.40 Quite High
Inflammation 18 77.96 Quite High
imagery 5 73.60 Quite High
cerebral cortex 1 72.16 Quite High
cytokine 17 66.84 Quite High
Spinal cord 2 65.84 Quite High
tolerance 1 30.88 Quite Low
Disease Link Frequency Relevance Heat
Low Back Pain 217 98.22 Very High Very High Very High
Thrombocytopenia 2 96.92 Very High Very High Very High
Generaliased Trisomy 1 95.72 Very High Very High Very High
Recurrence 22 95.68 Very High Very High Very High
Leukemia 30 95.36 Very High Very High Very High
Diffuse Large B-cell Lymphoma 2 93.88 High High
Hodgkin's Disease 2 91.40 High High
Rheumatoid Arthritis 28 89.52 High High
Lymphatic System Cancer 5 89.36 High High
Composite Lymphoma 2 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The T cells expressed CD2, CD3, CD5, CD7, and CD8, with partial loss of CD4.
Gene_expression (expressed) of CD7 in T cells
1) Confidence 0.53 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.73 Pain Relevance 0.10
CD57 surface expression was higher on CD4+CD28- T cells than on CD4+CD28+ T cells (63.0 ± 29.5% versus 1.0 ± 0.6 %; n = 7; P = 0.001), whereas the expression of CD7 was 72.4 ± 11.2% on CD28+ but only 3.4 ± 2.1% on CD28- CD4+ T cells (n = 7; P < 0.001; Fig. 4a).
Gene_expression (expression) of CD7 in T cells
2) Confidence 0.29 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0 Pain Relevance 0
For phenotypic characterization of CD4+CD28- T cells, surface expressions of CD57 and CD7 were compared between the CD28+ and the CD28- CD4+ T cell compartments.
Gene_expression (expressions) of CD7 in T cells
3) Confidence 0.29 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0.05 Pain Relevance 0.03
Flow cytometry of the bone marrow biopsy revealed that the majority of cells were immunoreactive for CD45, CD2, CD3, CD4, and CD30, whereas the expression of CD5 and CD7 was greatly reduced compared to CD2 and CD3.
Gene_expression (expression) of CD7 in bone marrow
4) Confidence 0.28 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC1824742 Disease Relevance 0.37 Pain Relevance 0
The CD7 molecule, which is involved in T cell activation, is present in most normal human T cells under physiological conditions, but not on NK cells [32].
Neg (not) Gene_expression (present) of CD7 molecule in T cells
5) Confidence 0.23 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0 Pain Relevance 0.03
Indeed, the CD4+CD28- T cells from AS patients that we tested expressed high levels of CD57 and NK receptors, but they lacked expression of CD7, thus sharing typical NK cell features [39].
Neg (lacked) Gene_expression (expression) of CD7 in T cells associated with spinal inflammation
6) Confidence 0.23 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.05 Pain Relevance 0.48
The following features were characteristic for these patients: (1) a 500-fold higher than expected incidence of megakaryoblastic leukemia (M7) with a peak incidence under 4 years of age; (2) a myelodysplastic prephase with thrombocytopenia lasting for several months up to a few years; (3) frequent involvement of the red cell lineage as suggested by dyserythropoiesis in the bone marrow; (4) coexpression of the lymphoid cell surface antigen CD7 on the leukemic blasts; (5) absence of the translocation t(1;22), instead presence of complete or partial trisomies involving chromosomes 8 and 1; and (6) a good response to chemotherapy.
Gene_expression (coexpression) of antigen CD7 in bone marrow associated with leukemia, thrombocytopenia and generaliased trisomy
7) Confidence 0.20 Published 1996 Journal Leukemia Section Abstract Doc Link 8892666 Disease Relevance 1.00 Pain Relevance 0.08
Immunophenotyping of the CSF cells demonstrated the cells were CD10 negative, strongly CD2 and CD7 positive and terminal deoxynucleotidyl transferase (TdT) negative.
Neg (negative) Gene_expression (positive) of CD7
8) Confidence 0.10 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1839762 Disease Relevance 0.61 Pain Relevance 0.14
Staining for CD2, CD3, CD5, CD7, CD20, CD23, CD33, CD14, CD15, AC133 and KOR-SA3544 was negative.
Neg (negative) Gene_expression (negative) of CD7
9) Confidence 0.09 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 15053308 Disease Relevance 0.57 Pain Relevance 0.08

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