INT660

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2011
Negated 7
Speculated 4
Reported most in Abstract
Documents 194
Total Number 198
Disease Relevance 82.06
Pain Relevance 29.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 71
blood 8
sympathetic 6
kidney 3
heart 3
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 26 100.00 Very High Very High Very High
noradrenaline 20 100.00 Very High Very High Very High
Clonidine 181 99.98 Very High Very High Very High
agonist 29 99.96 Very High Very High Very High
beta blocker 109 99.92 Very High Very High Very High
antagonist 155 99.82 Very High Very High Very High
COX-2 inhibitor 5 99.70 Very High Very High Very High
anesthesia 75 99.50 Very High Very High Very High
diclofenac 3 99.50 Very High Very High Very High
Opioid 12 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1614 100.00 Very High Very High Very High
Heart Rate Under Development 382 100.00 Very High Very High Very High
Proteinuria 74 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 62 100.00 Very High Very High Very High
Weight Loss 58 100.00 Very High Very High Very High
Body Weight 32 100.00 Very High Very High Very High
Bradycardia 8 100.00 Very High Very High Very High
Hyperglycemia 131 99.96 Very High Very High Very High
Heart Disease 14 99.96 Very High Very High Very High
Renal Disease 332 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged treatment with indomethacin also produced some of the symptoms of a syndrome of hypoprostaglandinism, such as decreased plasma renin activity, plasma aldosterone, and urinary prostaglandin E2 in association with increases in plasma potassium levels and diastolic pressure.
Negative_regulation (decreased) of renin in plasma associated with syndrome
1) Confidence 0.59 Published 1986 Journal Hypertension Section Abstract Doc Link 3525404 Disease Relevance 0.44 Pain Relevance 0.12
In patients with hypertension, bisoprolol diminishes plasma renin activity, platelet aggregation, effective renal plasma flow, and creatinine clearance.
Negative_regulation (diminishes) of renin in plasma
2) Confidence 0.59 Published 1995 Journal Ann Pharmacother Section Body Doc Link 7633020 Disease Relevance 0 Pain Relevance 0
In these animals, clonidine produced hypotension and bradycardia and suppressed plasma renin activity to 39 percent of the control value.
Negative_regulation (suppressed) of plasma renin in plasma associated with cv unclassified under development, bradycardia and clonidine
3) Confidence 0.58 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1120965 Disease Relevance 0.56 Pain Relevance 0.57
Intravenous clonidine produced a transient hypertension followed by hypotension, decreased heart rate and suppressed plasma renin activity to 49 percent of the control value.
Negative_regulation (suppressed) of plasma renin in plasma associated with cv unclassified under development, bradycardia and clonidine
4) Confidence 0.58 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1120965 Disease Relevance 0.62 Pain Relevance 0.72
Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were markedly suppressed in the first episode occurring in paralell with the administration of metoprolol during piroxicam and lobenzarit (CCA) therapy.
Negative_regulation (suppressed) of renin in plasma associated with heart rate under development
5) Confidence 0.58 Published 1991 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 1685199 Disease Relevance 0.97 Pain Relevance 0.33
In addition, 9 of 11 patients, selected randomly from 72 bedridden elderly patients with normal serum sodium and potassium levels in our hospital, had diminished plasma renin activity (PRA) and plasma aldosterone concentration (PAC).
Negative_regulation (diminished) of renin in plasma associated with heart rate under development
6) Confidence 0.58 Published 2010 Journal Intern. Med. Section Abstract Doc Link 20154436 Disease Relevance 0.77 Pain Relevance 0.35
Intraventricular clonidine produced similar alterations in blood pressure and heart rate in another group of dogs in which renal perfusion pressure was not controlled, but failed to suppress plasma renin activity.
Neg (failed) Negative_regulation (suppress) of plasma renin in heart associated with cv unclassified under development and clonidine
7) Confidence 0.58 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1120965 Disease Relevance 0.62 Pain Relevance 0.72
The occurrence of chronic renal failure in strict relationship with maternal nimesulide assumption in this case is strongly suggestive for a pharmacological damage, either direct or mediated by renin angiotensin inhibition, and possibly modulated by genetic factors, likely to account for the different outcome of similarly treated patients.
Negative_regulation (inhibition) of renin associated with chronic renal failure
8) Confidence 0.57 Published 2001 Journal Minerva Urol Nefrol Section Abstract Doc Link 11455321 Disease Relevance 0.77 Pain Relevance 0.05
Drugs inhibiting the renin-angiotensin-aldosterone (RAAS) and sympathetic nervous systems have become the standard of care following several landmark clinical trials demonstrating their effectiveness.
Negative_regulation (inhibiting) of renin in sympathetic nervous systems
9) Confidence 0.57 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899804 Disease Relevance 1.12 Pain Relevance 0
A rat model that provides a rapid method for the in vivo evaluation of potential inhibitors of human renin has been developed and validated.
Negative_regulation (inhibitors) of renin
10) Confidence 0.57 Published 1990 Journal J Pharmacol Methods Section Abstract Doc Link 2196401 Disease Relevance 0.15 Pain Relevance 0
It is concluded that S 2864 is an effective specific inhibitor of human renin eliciting marked blood pressure lowering activities in primates.
Negative_regulation (inhibitor) of renin in blood associated with hypotension
11) Confidence 0.56 Published 1994 Journal Arzneimittelforschung Section Abstract Doc Link 7945514 Disease Relevance 0.10 Pain Relevance 0
Thus, the majority of hyperkalemic patients with SLE had an impaired renin and aldosterone response to stimulation.
Negative_regulation (impaired) of renin associated with hyperkalemia and systemic lupus erythematosus
12) Confidence 0.56 Published 1988 Journal Arch. Intern. Med. Section Abstract Doc Link 3277563 Disease Relevance 1.01 Pain Relevance 0.12
Thus, two mechanisms of action of clonidine are possible, one related to acute inhibition of the renin-angiotensin system in patients with high and normal renin levels and another that is independent of renin mechanisms and occurs in all hypertensive patients.
Negative_regulation (inhibition) of renin associated with hypertension and clonidine
13) Confidence 0.55 Published 1976 Journal Am. J. Cardiol. Section Abstract Doc Link 998518 Disease Relevance 0.49 Pain Relevance 0.33
Clonidine (30 microgram/kg, iv) lowered mean arterial pressure (MAP) from 124 +/- 8 to 104 +/- 4 mm Hg (P less than 0.01) and reduced plasma renin activity (PRA) to 32 +/- 4 percent of the control value (P less than 0.01) after 60 minutes.
Negative_regulation (reduced) of renin in plasma associated with clonidine
14) Confidence 0.55 Published 1978 Journal Circ. Res. Section Abstract Doc Link 620441 Disease Relevance 0.24 Pain Relevance 0.33
Absolute clonidine-induced reduction in plasma renin activity after diuretic treatment was three times greater than before treatment, although percent changes were similar.
Negative_regulation (reduction) of renin in plasma associated with clonidine
15) Confidence 0.53 Published 1986 Journal Hypertension Section Abstract Doc Link 3514447 Disease Relevance 0.17 Pain Relevance 0.72
Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers.
Negative_regulation (inhibitor) of renin associated with hypertension
16) Confidence 0.53 Published 2006 Journal Int. J. Clin. Pract. Section Title Doc Link 17073832 Disease Relevance 0.10 Pain Relevance 0
Aliskiren inhibited plasma renin activity (PRA) and also prevented the reactive rise in PRA induced by valsartan.
Negative_regulation (inhibited) of renin in plasma
17) Confidence 0.53 Published 2006 Journal Int. J. Clin. Pract. Section Abstract Doc Link 17073832 Disease Relevance 0.33 Pain Relevance 0.09
Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor.
Negative_regulation (inhibitor) of renin
18) Confidence 0.52 Published 2008 Journal Pharmacol Rep Section Title Doc Link 19066408 Disease Relevance 0.37 Pain Relevance 0.18
In contrast to other antihypertensive agents, aliskiren decreases plasma renin activity (PRA).
Negative_regulation (decreases) of renin in plasma
19) Confidence 0.52 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19066408 Disease Relevance 0.35 Pain Relevance 0.17
It is possible that its blood pressure lowering effect is due, at least in part, to a suppression of the plasma renin activity.
Negative_regulation (suppression) of renin in plasma associated with hypotension
20) Confidence 0.51 Published 1976 Journal Klin. Wochenschr. Section Abstract Doc Link 790007 Disease Relevance 0.65 Pain Relevance 0.05

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