INT66004

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 12.82
Pain Relevance 18.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
brain 2
spleen 1
dorsal horn 1
vas deferens 1
microglial cells 1
Cnr2 (Mus musculus)
Cnr2 - Q63R (1)
Pain Link Frequency Relevance Heat
Cannabinoid 659 100.00 Very High Very High Very High
Cannabinoid receptor 160 100.00 Very High Very High Very High
agonist 424 99.98 Very High Very High Very High
Neuronal excitability 4 99.92 Very High Very High Very High
depression 76 99.76 Very High Very High Very High
Glutamate 35 99.72 Very High Very High Very High
Endocannabinoid 308 99.64 Very High Very High Very High
antagonist 189 99.16 Very High Very High Very High
Antihyperalgesic 6 99.04 Very High Very High Very High
Neurotransmitter 19 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Gliosis 4 99.88 Very High Very High Very High
Depression 76 99.76 Very High Very High Very High
Alcohol Addiction 12 99.20 Very High Very High Very High
Nociception 94 98.96 Very High Very High Very High
Peripheral Neuropathy 112 98.88 Very High Very High Very High
Cancer Pain 4 98.48 Very High Very High Very High
Spasticity 56 98.18 Very High Very High Very High
Pain 285 98.04 Very High Very High Very High
Diabetes Mellitus 616 98.00 Very High Very High Very High
Neuropathic Pain 503 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association of CB2 gene variation was probed in Japanese subjects to examine the non-synonymous polymorphism, Q63R, in the CB2 gene for association with depression or alcoholism.
CB2 gene (Q63R) Binding (association) of associated with alcohol addiction and depression
1) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 1.07 Pain Relevance 0.37
Although all (+)-cannabidiols bind to cannabinoid CB1 and CB2 receptors, only (+)-7-OH-cannabidiol-DMH was centrally active, while all (+)-cannabidiol analogues completely arrested defecation.
CB2 Binding (bind) of associated with cannabinoid
2) Confidence 0.47 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15588739 Disease Relevance 0.25 Pain Relevance 0.41
We then examined the association between CB2 gene polymorphism and depression in a human population to test the hypothesis that genetic variants of CB2 gene might be associated with depression and substance abuse in Japanese population.
CB2 gene Spec (examined) Binding (association) of associated with depression and drug abuse
3) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.34 Pain Relevance 0.51
The CB2 selectivities in the O,2-propano analogs may be due to differences in solvation/desolvation that occur when the ligands enter the CB1 vs CB2 binding site.
CB2 Binding (enter) of
4) Confidence 0.37 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9379452 Disease Relevance 0 Pain Relevance 0.24
O,2-Propano-11-delta 8-THC, O,2-propano delta 9,11-THC, O,2-propano-9-oxo-11-nor-hexahydrocannabinol (O,2-propano-9-oxo-11-nor-HHC), and O,2-propano-9 alpha- and O,2-propano-9 beta-OH-11-nor-HHC were synthesized and evaluated in radioligand displacement assays for affinity at the CB1 and CB2 receptors and in the mouse vas deferens in vitro assay and the mouse tetrad in vivo assay for cannabinoid activity.
CB2 Binding (affinity) of in vas deferens associated with cannabinoid
5) Confidence 0.37 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9379452 Disease Relevance 0 Pain Relevance 0.21
Another nonpsychoactive endogenous compound, the anti-inflammatory mediator PEA (Lambert and Di Marzo 1999), also induced a significant, albeit transient inhibition of spasticity (Pryce and Baker 2007); however, the mechanism of action of this compound, which does not bind appreciably to CB1 or CB2 receptors, is still a matter of speculation (Lambert and Di Marzo 1999).
CB2 Neg (not) Binding (bind) of associated with spasticity and inflammation
6) Confidence 0.37 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 1.30 Pain Relevance 0.42
In the dorsal horn (L4-L6) of neuropathic mice microglia activation (quantification of the length of microglial processes) and astrocytosis were associated with CB2 receptor over-expression on both cell types.
CB2 Binding (associated) of in dorsal horn associated with neuropathic pain, dorsal horn and gliosis
7) Confidence 0.37 Published 2010 Journal Neurobiol. Dis. Section Abstract Doc Link 19804829 Disease Relevance 1.14 Pain Relevance 0.99
Specifically, three compounds, 1, 2 and 3 showed high affinity for CB2 as well as high selectivity over CB1 receptors.
CB2 Binding (affinity) of
8) Confidence 0.36 Published 2010 Journal Pharmacol. Res. Section Abstract Doc Link 19961936 Disease Relevance 0.08 Pain Relevance 0.25
The new compounds were tested in vitro for CB1 and CB2 receptor affinity in comparison with the reference compounds rimonabant and SR144528.
CB2 Binding (affinity) of
9) Confidence 0.36 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18680276 Disease Relevance 0 Pain Relevance 0.26
Because methanandamide binds poorly to CB2 receptors, these results suggest possible non-CB1, non-CB2 mechanisms of action for methanandamide-induced behavioral disruption of lever press responding.
CB2 Binding (binds) of in lever
10) Confidence 0.35 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718593 Disease Relevance 0.07 Pain Relevance 0.27
2-Arachidonoyl-glycerol (2-Ara-GI) has been isolated from various tissues and identified as an endogenous ligand for both cannabinoid receptors, CB1 and CB2.
CB2 Binding (ligand) of associated with cannabinoid receptor
11) Confidence 0.35 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9721036 Disease Relevance 0.05 Pain Relevance 0.18
AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo.
CB2 Binding (binds) of associated with endocannabinoid and cannabinoid receptor
12) Confidence 0.32 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 19053765 Disease Relevance 0 Pain Relevance 0.59
Tetrahydrocannabinol (THC), a component in marijuana, acts at both CB1 and CB2 receptors, but other forms of cannabinoids such as cannabinol and cannabidiol act predominantly at CB2 receptors.
CB2 Binding (receptors) of associated with cannabinoid
13) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 0.35 Pain Relevance 0.56
CB2 receptors are associated with immune cells, microglia and have been identified in the peripheral nervous system.
CB2 Binding (associated) of in peripheral nervous system associated with peripheral nervous system
14) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 0.55 Pain Relevance 0.97
Although endocannabinoids, including anandamide and 2-arachidonoylglycerol (2-AG) [26], act upon CB1 and CB2 receptors are secreted by neurons, they are more prominently produced in microglial cells during neuroinflammatory conditions. 2-AG promotes recruitment of microglial cells by ligation of CB2, but not CB1 receptors [26].
CB2 Binding (ligation) of in microglial cells associated with endocannabinoid
15) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 0.18 Pain Relevance 0.39
Next, we examined whether CB2 receptor ligation could prevent microglial activation and migration.
CB2 Binding (ligation) of
16) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 1.22 Pain Relevance 1.01
The compound binds with high affinity to human CB2 or mouse CB2 expressed on CHO cell membrane and to rat CB2 on splenocytes.
CB2 Binding (binds) of
17) Confidence 0.30 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11160626 Disease Relevance 0 Pain Relevance 0.14
The compound binds with high affinity to human CB2 or mouse CB2 expressed on CHO cell membrane and to rat CB2 on splenocytes.
CB2 Binding (binds) of
18) Confidence 0.30 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11160626 Disease Relevance 0 Pain Relevance 0.14
In the cancer pain model, the antihyperalgesic effect of WIN55,212-2 was partially blocked by pretreatment with the selective CB1 (SR141716A) but not the CB2 (SR144528) receptor antagonist.
CB2 Binding (pretreatment) of associated with antihyperalgesic, cancer pain and antagonist
19) Confidence 0.30 Published 2003 Journal Pain Section Abstract Doc Link 12749972 Disease Relevance 1.83 Pain Relevance 1.81
The compound binds with high affinity to human CB2 or mouse CB2 expressed on CHO cell membrane and to rat CB2 on splenocytes.
CB2 Binding (binds) of
20) Confidence 0.26 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11160626 Disease Relevance 0 Pain Relevance 0.14

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