INT6601

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Context Info
Confidence 0.27
First Reported 1987
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 3.13
Pain Relevance 5.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PPAP2A) plasma membrane (PPAP2A) lipid metabolic process (PPAP2A)
Anatomy Link Frequency
motoneurons 2
nerves 2
sympathetic 2
SH-SY5Y 1
Odontoblasts 1
PPAP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 41 100.00 Very High Very High Very High
agonist 35 100.00 Very High Very High Very High
Opioid 2 99.60 Very High Very High Very High
Action potential 17 99.40 Very High Very High Very High
sodium channel 4 99.08 Very High Very High Very High
tetrodotoxin 1 94.24 High High
Clonidine 39 91.56 High High
opioid receptor 2 90.72 High High
Chronic pancreatitis 1 90.60 High High
Potency 5 87.16 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 4 100.00 Very High Very High Very High
Neuroma 2 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 9 98.00 Very High Very High Very High
Pancreatic Cancer 10 97.76 Very High Very High Very High
Rheumatoid Arthritis 6 92.72 High High
Pancreatitis 1 90.60 High High
Adhesions 11 86.36 High High
Pain 4 86.04 High High
Nervous System Injury 7 84.60 Quite High
Obesity 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animal studies have suggested that vasoconstrictor alpha-2 adrenoreceptors exist on vascular smooth muscle cells.
Gene_expression (exist) of alpha-2 in smooth muscle cells
1) Confidence 0.27 Published 1987 Journal Clin Invest Med Section Abstract Doc Link 3028681 Disease Relevance 0 Pain Relevance 0.40
Thus, this provides pharmacological evidence that postjunctional vascular smooth muscle alpha-2 adrenoreceptors exist in man and can modulate blood pressure.
Gene_expression (exist) of alpha-2 in blood
2) Confidence 0.27 Published 1987 Journal Clin Invest Med Section Abstract Doc Link 3028681 Disease Relevance 0 Pain Relevance 0.60
Activity levels of alpha 2 and alpha 3-motoneurons in the occasional spike mode varied between 0 and 3 Ap's/sec per fibre.
Gene_expression (levels) of alpha 2 in motoneurons associated with action potential
3) Confidence 0.26 Published 1991 Journal Electromyogr Clin Neurophysiol Section Abstract Doc Link 1831752 Disease Relevance 0.07 Pain Relevance 0.20
Odontoblasts express neuronal isoforms of alpha2 and beta2 subunits of sodium channels.
Gene_expression (express) of alpha2 in Odontoblasts associated with sodium channel
4) Confidence 0.26 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16831873 Disease Relevance 0.16 Pain Relevance 0.48
Concomitant with an enhanced expression of mu-opioid binding sites, the levels of the inhibitory G proteins Gi alpha 1 and Gi alpha 2 were found to be significantly increased.
Gene_expression (levels) of Gi alpha 2 associated with opioid
5) Confidence 0.13 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.25 Pain Relevance 0.14
Western blot analysis, using subtype-specific anti-G protein antibodies, revealed the presence of the following G protein subunits in human neuroblastoma SH-SY5Y cells: Gs alpha, Gi alpha 1, Gi alpha 2, Go alpha, Gz alpha, and G beta.
Gene_expression (presence) of Gi alpha 2 in SH-SY5Y associated with neuroblastoma
6) Confidence 0.13 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.27 Pain Relevance 0.11
It is concluded that alpha-1 and alpha-2 adrenoceptors are present in human digital vasculature and that alpha-2 adrenoceptors are more important than alpha-1 adrenoceptors in sympathetic neural vasoconstriction.
Gene_expression (present) of alpha-2 in sympathetic associated with increased venous pressure under development
7) Confidence 0.13 Published 1988 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2843379 Disease Relevance 0.17 Pain Relevance 0.27
It is concluded that alpha-1 and alpha-2 adrenoceptors are present in human digital vasculature and that alpha-2 adrenoceptors are more important than alpha-1 adrenoceptors in sympathetic neural vasoconstriction.
Gene_expression (important) of alpha-2 in sympathetic associated with increased venous pressure under development
8) Confidence 0.13 Published 1988 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2843379 Disease Relevance 0.17 Pain Relevance 0.26
The intrafusal motoneurons fired with patterns very similar to those of secondary spindle afferents, and they did not fire in the oscillatory mode for high activations as alpha 2 and alpha 3-motoneurons do. 3.
Gene_expression (do) of alpha 2 in motoneurons
9) Confidence 0.11 Published 1993 Journal Electromyogr Clin Neurophysiol Section Abstract Doc Link 8306918 Disease Relevance 0 Pain Relevance 0.25
Beta-2 and alpha-2 adrenoceptors are resistant in this respect whereas activation of beta-1 adrenoceptors leads to rapid desensitization.
Gene_expression (resistant) of alpha-2
10) Confidence 0.09 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1681086 Disease Relevance 0.13 Pain Relevance 0.45
Expression and function of VLA-alpha 2, -alpha 3, -alpha 5 and -alpha 6-integrin receptors in pancreatic carcinoma.
Gene_expression (Expression) of alpha 2 associated with pancreatic cancer
11) Confidence 0.07 Published 1992 Journal Int. J. Cancer Section Title Doc Link 1330937 Disease Relevance 0.78 Pain Relevance 0.09
In contrast, oxybutynin significantly reduced EEG power in 4 bands: theta, alpha 1, alpha 2, beta 1.
Gene_expression (theta) of alpha 2 in bands
12) Confidence 0.05 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661617 Disease Relevance 0.21 Pain Relevance 0.10
The alpha-2 and I1 sites were labeled with [125I]p-iodoclonidine and the I2b sites were labeled with [3H]-idazoxan.
Gene_expression (labeled) of alpha-2
13) Confidence 0.03 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7853171 Disease Relevance 0 Pain Relevance 0.44
First, in competition binding experiments at h alpha2A and h5-HT1A receptors expressed in CHO cells, several compounds, including the antagonists 1-(2-pyrimidinyl)piperazine (1-PP), (+/-)-idazoxan, benalfocin (SKF 86466), yohimbine and RX 821,002, displayed preference for h alpha2A versus h5-HT1A receptors of only 1.4-, 3.6-, 4-, 10- and 11-fold, respectively (based on differences in pKi values).
Gene_expression (expressed) of alpha2A associated with antagonist
14) Confidence 0.02 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.26
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Gene_expression (selective) of alpha2A associated with antagonist and agonist
15) Confidence 0.02 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.31
For example, (+/-)-idazoxan was only 3.6-fold selective for h alpha2A versus h5-HT1A but 51-fold selective for r alpha2A versus r5-HT1A receptors.
Gene_expression (selective) of alpha2A
16) Confidence 0.02 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.32
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Gene_expression (selective) of alpha2A associated with antagonist and agonist
17) Confidence 0.02 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.31
Induced synthesis of proPAP 2 was detected in plasmatocytes; by immunofluorescence labeling.
Gene_expression (synthesis) of proPAP 2 in plasmatocytes
18) Confidence 0.02 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0 Pain Relevance 0
Many DRG cell somata, and their axons in intact nerves and nerve end neuromas, express alpha2A adrenoreceptors intracytoplasmically and on their membrane surface.
Gene_expression (express) of alpha2A in nerve associated with neuroma
19) Confidence 0.02 Published 1999 Journal J. Neurocytol. Section Abstract Doc Link 10859576 Disease Relevance 0.41 Pain Relevance 0.23
Chinese hamster ovary (CHO) cells stably transfected to express different densities of the human alpha2A-, alpha2B- and alpha2C-adrenoceptor subtypes, were used to characterize the regulation of adenylyl cyclase activity by alpha2-adrenoceptor agonists.
Gene_expression (express) of alpha2A in ovary associated with agonist
20) Confidence 0.01 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9371546 Disease Relevance 0.12 Pain Relevance 0.08

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