INT6602

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Context Info
Confidence 0.56
First Reported 1992
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 1.75
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RPS6KA6) nucleoplasm (RPS6KA6) signal transduction (RPS6KA6)
nucleus (RPS6KA6) cytoplasm (RPS6KA6)
Anatomy Link Frequency
Langerhans cells 2
epidermal cells 1
pancreas 1
mast cell 1
RPS6KA6 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 8 99.24 Very High Very High Very High
cytokine 4 99.14 Very High Very High Very High
Morphine 4 98.76 Very High Very High Very High
Chronic pancreatitis 2 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 20 99.08 Very High Very High Very High
Necrosis 4 98.12 Very High Very High Very High
Cancer 10 97.94 Very High Very High Very High
Pancreatitis 2 96.64 Very High Very High Very High
Adhesions 12 87.68 High High
Metastasis 2 58.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of tumor necrosis factor-alpha (TNF alpha), the predominant cytokine in mast cell granules, also induced LC to express alpha 6 integrins.
Gene_expression (express) of alpha 6 in mast cell associated with necrosis, cancer and cytokine
1) Confidence 0.56 Published 1993 Journal J. Invest. Dermatol. Section Abstract Doc Link 8345216 Disease Relevance 0.20 Pain Relevance 0.21
The expression of the alpha 6 beta 4 and alpha 6 beta 1 integrins on epidermal Langerhans cells (LC) before and after mast cell degranulation was studied in cultured human neonatal foreskin by immunohistochemistry.
Gene_expression (expression) of alpha 6 in Langerhans cells
2) Confidence 0.49 Published 1993 Journal J. Invest. Dermatol. Section Abstract Doc Link 8345216 Disease Relevance 0 Pain Relevance 0.12
The expression of the alpha 6 beta 4 and alpha 6 beta 1 integrins on epidermal Langerhans cells (LC) before and after mast cell degranulation was studied in cultured human neonatal foreskin by immunohistochemistry.
Gene_expression (expression) of alpha 6 in Langerhans cells
3) Confidence 0.49 Published 1993 Journal J. Invest. Dermatol. Section Abstract Doc Link 8345216 Disease Relevance 0 Pain Relevance 0.12
Twenty-four hours after addition of mast cell secretagogues, morphine sulfate, or substance P, solitary mid-epidermal cells showed staining for the integrin subunits alpha 6, beta 4, and beta 1.
Gene_expression (staining) of alpha 6 in epidermal cells associated with substance p and morphine
4) Confidence 0.43 Published 1993 Journal J. Invest. Dermatol. Section Abstract Doc Link 8345216 Disease Relevance 0.14 Pain Relevance 0.18
Expression and function of VLA-alpha 2, -alpha 3, -alpha 5 and -alpha 6-integrin receptors in pancreatic carcinoma.
Gene_expression (Expression) of alpha 6 associated with pancreatic cancer
5) Confidence 0.05 Published 1992 Journal Int. J. Cancer Section Title Doc Link 1330937 Disease Relevance 0.84 Pain Relevance 0.09
The expression of the VLA-integrins alpha 2, alpha 3, alpha 5 and alpha 6 was studied immunohistochemically in tissue samples from ductal pancreatic cancer, chronic pancreatitis, normal pancreas and in 8 cell lines of ductal human pancreatic cancer.
Gene_expression (expression) of alpha 6 in pancreas associated with pancreatic cancer and chronic pancreatitis
6) Confidence 0.05 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 0.57 Pain Relevance 0.10

General Comments

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