INT66023

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Context Info
Confidence 0.64
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 12.65
Pain Relevance 16.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
microglia 20
neutrophil 10
macrophage 3
monocyte 3
spinal nerve 2
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 63 100.00 Very High Very High Very High
Morphine 507 99.98 Very High Very High Very High
intrathecal 61 99.40 Very High Very High Very High
Inflammation 151 99.20 Very High Very High Very High
Central grey 2 99.00 Very High Very High Very High
Spinal cord 202 98.80 Very High Very High Very High
Eae 19 97.92 Very High Very High Very High
Pain 161 96.48 Very High Very High Very High
Neuropeptide 10 96.16 Very High Very High Very High
Duloxetine 44 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 37 100.00 Very High Very High Very High
Diabetes Mellitus 6 99.74 Very High Very High Very High
Hypertrophy 28 99.50 Very High Very High Very High
INFLAMMATION 174 99.20 Very High Very High Very High
Urological Neuroanatomy 6 99.00 Very High Very High Very High
Gliosis 86 98.82 Very High Very High Very High
Injury 174 97.08 Very High Very High Very High
Pain 227 96.48 Very High Very High Very High
Nociception 112 96.04 Very High Very High Very High
Hyperalgesia 175 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical experiments revealed that the expression of CD11b, a marker protein of microglia, was increased in the hypothalamus and periaqueductal gray in the chronic constriction injury rat brain as compared with the controls, and memantine treatment could suppress the activation of microglia, suggesting the involvement of microglia in pain mechanism.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in microglia associated with pain, eae, injury and central grey
1) Confidence 0.64 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 19653132 Disease Relevance 1.50 Pain Relevance 1.53
Following one week of diabetes, neutrophil CD11a, CD11b, and CD18 expression was increased significantly, as were retinal ICAM-1 levels.
Positive_regulation (increased) of Gene_expression (expression) of CD11a in neutrophil associated with diabetes mellitus
2) Confidence 0.54 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.13 Pain Relevance 0.44
CD11b/c expression was greater in PMNs of saline treated postreproductive females, than in reproductive or prereproductive animals, but an ET challenge upregulated CD11b/c expression to the same level in all three groups.
Positive_regulation (upregulated) of Gene_expression (expression) of CD11b in PMNs
3) Confidence 0.49 Published 1996 Journal Inflammation Section Abstract Doc Link 8894713 Disease Relevance 0 Pain Relevance 0.23
Similarly the two groups did not differ in the number of cells stained for the complement type 3 receptor CD11b which labels microglia (Supplementary Figures S4C & S4D, t13?
Positive_regulation (for) of Gene_expression (labels) of CD11b in microglia
4) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.47 Pain Relevance 0.07
Similarly the two groups did not differ in the number of cells stained for the complement type 3 receptor CD11b which labels microglia (Supplementary Figures S4C & S4D, t13?
Positive_regulation (for) of Gene_expression (stained) of CD11b in microglia
5) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.47 Pain Relevance 0.07
Neutrophils collected from thiopental-treated rats had elevated CD11b expression with thiopental (mean fluorescence baseline, 67.5 +/- 1.3; hemorrhage, 83.6 +/- 5.3; P < 0.05) but not with propofol/fentanyl (mean fluorescence baseline, 69.1 +/- 1.3; hemorrhage, 65.9 +/- 1.6), and ketamine-treated rats (mean fluorescence baseline, 74.3 +/- 2.1; hemorrhage, 74.8 +/- 1.1).
Positive_regulation (elevated) of Gene_expression (expression) of CD11b in Neutrophils
6) Confidence 0.47 Published 2006 Journal Shock Section Body Doc Link 16680014 Disease Relevance 0.12 Pain Relevance 0
CONCLUSIONS: After hemorrhage, leukocyte adhesion and CD11b expression increased during thiopental anesthesia, but propofol/fentanyl and ketamine protected against hemorrhage-induced leukocyte adhesion.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in leukocyte
7) Confidence 0.47 Published 2006 Journal Shock Section Body Doc Link 16680014 Disease Relevance 0 Pain Relevance 0
The spinal lumbar mRNA expression of ITGAM, TLR4, and CD14 was upregulated at 4 h post surgery, CD14 peaked 4 days after spinal nerve transection while ITGAM and TLR4 continued to increase until day 14 and returned to almost normal levels by postoperative day 28.
Positive_regulation (upregulated) of Gene_expression (expression) of ITGAM in spinal nerve
8) Confidence 0.46 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.42 Pain Relevance 0.35
Following one week of diabetes, neutrophil CD11a, CD11b, and CD18 expression was increased significantly, as were retinal ICAM-1 levels.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in neutrophil associated with diabetes mellitus
9) Confidence 0.39 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.13 Pain Relevance 0.44
In the literature, the most frequently described marker/antibody for detection of microglia and microgliosis is OX42 since the constitutively expressed CD11b is upregulated in parallel to the activation-induced morphological transformation of microglia (Ladeby et al., 2005).
Positive_regulation (upregulated) of Gene_expression (expressed) of CD11b in microglia
10) Confidence 0.36 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0 Pain Relevance 0.03
Immunohistochemical and Western blot analyses of ventricular tissue demonstrated that NMDA receptor blockade abolished MgD-related increase of endothelium adhesion molecule CD54 (weeks 1 and 2; p < 0.05), and of monocyte/macrophage surface protein CD11b expression (week 3; p < 0.05).
Positive_regulation (increase) of Gene_expression (expression) of CD11b in monocyte associated with nmda receptor and adhesions
11) Confidence 0.29 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15169828 Disease Relevance 0.23 Pain Relevance 0.60
A role of microglia is suggested by the observation that intrathecal choline suppressed the gp120-induced expression of, cd11b, a macrophage/microglial activation marker.
Positive_regulation (induced) of Gene_expression (expression) of cd11b in macrophage associated with intrathecal
12) Confidence 0.26 Published 2010 Journal Brain Behav. Immun. Section Abstract Doc Link 20353818 Disease Relevance 0.89 Pain Relevance 1.44
-thymosin or CD11b staining of microglia and an apparent increase in the number of microglia in sections of the red nucleus containing regenerating neurons (Fig 9a-d).
Positive_regulation (increase) of Gene_expression (staining) of CD11b in microglia
13) Confidence 0.26 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0 Pain Relevance 0
In the literature, the most frequently described marker/antibody for detection of microglia and microgliosis is OX42 since the constitutively expressed CD11b is upregulated in parallel to the activation-induced morphological transformation of microglia (Ladeby et al., 2005).
Positive_regulation (upregulated) of Gene_expression (expressed) of CD11b in microglia
14) Confidence 0.26 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0 Pain Relevance 0.03
CD11b labeling in contralateral control regions was faint and diffuse by comparison (Figure 5A), indicating that OX-42 – positive cells were recruited to the injured area or that those present markedly increased the expression of CD11b.
Positive_regulation (increased) of Gene_expression (expression) of CD11b
15) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2527306 Disease Relevance 0.33 Pain Relevance 0.22
There was also an increase in CD11b immunostaining after tendon ligation (Fig. 6a, CD11b: TL-3 d and 2w).


Positive_regulation (increase) of Gene_expression (immunostaining) of CD11b in tendon
16) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.69 Pain Relevance 0.91
In the same region, persistent upregulation of NMDA receptor NR1 phosphorylation and protein expression and increased expression of glial markers glial fibrillary acidic protein (astroglia) and CD11b (microglia) were found.
Positive_regulation (upregulation) of Gene_expression (expression) of CD11b in microglia associated with nmda receptor
17) Confidence 0.21 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2914030 Disease Relevance 0.96 Pain Relevance 0.88
In the same region, persistent upregulation of NMDA receptor NR1 phosphorylation and protein expression and increased expression of glial markers glial fibrillary acidic protein (astroglia) and CD11b (microglia) were found.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in microglia associated with nmda receptor
18) Confidence 0.21 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2914030 Disease Relevance 0.94 Pain Relevance 0.86
The masseter tendon ligation also upregulated the levels of CD11b, a marker of activated microglia.
Positive_regulation (upregulated) of Gene_expression (levels) of CD11b in microglia
19) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.64 Pain Relevance 0.52
Similarly, increased CD3/CD11B expression was observed in morphine-treated animals compared to controls (Figure 3B), which was attenuated by co-administration of ultra-low dose naltrexone.
Positive_regulation (increased) of Gene_expression (expression) of CD3/CD11B associated with morphine
20) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.13 Pain Relevance 0.82

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