INT66024

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.50
Pain Relevance 4.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
leukocyte 4
PMNs 3
macrophage 2
endothelium 1
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 11 99.98 Very High Very High Very High
aspirin 18 99.88 Very High Very High Very High
intrathecal 18 99.82 Very High Very High Very High
cva 8 99.72 Very High Very High Very High
Inflammation 80 99.54 Very High Very High Very High
cytokine 42 99.36 Very High Very High Very High
Etanercept 12 98.64 Very High Very High Very High
Inflammatory response 5 97.92 Very High Very High Very High
Cancer pain 49 95.20 Very High Very High Very High
Spinal cord 13 94.32 High High
Disease Link Frequency Relevance Heat
Hemorrhage 6 99.72 Very High Very High Very High
Adhesions 23 99.20 Very High Very High Very High
INFLAMMATION 77 97.74 Very High Very High Very High
Bone Cancer 54 95.00 High High
Neuropathic Pain 24 93.40 High High
Necrosis 4 90.84 High High
Cancer 22 90.48 High High
Urological Neuroanatomy 8 85.48 High High
Diabetes Mellitus 6 82.08 Quite High
Gastroesophageal Reflux Disease 45 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravenous anesthesia inhibits leukocyte-endothelial interactions and expression of CD11b after hemorrhage.
Negative_regulation (inhibits) of Gene_expression (expression) of CD11b in leukocyte associated with anesthesia and cva
1) Confidence 0.59 Published 2006 Journal Shock Section Title Doc Link 16680014 Disease Relevance 0.39 Pain Relevance 0.48
We have reported that inactive forms of lansoprazole and omeprazole circulating in the blood suppressed important aspects of the acute inflammatory response, such as the adhesion of neutrophils to the endothelium and extravascular migration of neutrophils, by inhibiting the expression of CD11b/CD18 (a neutrophil adhesion molecule) and by inhibiting IL-8 synthesis in gastric mucosal epithelial cells and endothelial cells [39, 45].
Negative_regulation (inhibiting) of in neutrophils Gene_expression (expression) of CD11b in endothelium associated with inflammatory response and adhesions
2) Confidence 0.57 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 1.29 Pain Relevance 0.22
High-dose aspirin also reduced the expression of CD11a, CD11b, and CD18, whereas meloxicam and etanercept did not.
Negative_regulation (reduced) of Gene_expression (expression) of CD11a associated with aspirin and etanercept
3) Confidence 0.45 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.02 Pain Relevance 0.72
The anti-inflammatory effect of ketamine was mediated by direct inhibition of CD11b expression on leukocytes.


Negative_regulation (inhibition) of Gene_expression (expression) of CD11b in leukocytes
4) Confidence 0.43 Published 2006 Journal Shock Section Body Doc Link 16680014 Disease Relevance 0 Pain Relevance 0
We explored gender differences in phagocytosis by neutrophils (PMNs), CD11b/c expression, generation of cytokine-induced neutrophil chemoattractant (CINC) and the influence of developmental stages on some of these parameters.
Negative_regulation (explored) of Gene_expression (expression) of CD11b in PMNs associated with cytokine
5) Confidence 0.41 Published 1996 Journal Inflammation Section Abstract Doc Link 8894713 Disease Relevance 0 Pain Relevance 0.17
High-dose aspirin also reduced the expression of CD11a, CD11b, and CD18, whereas meloxicam and etanercept did not.
Negative_regulation (reduced) of Gene_expression (expression) of CD11b associated with aspirin and etanercept
6) Confidence 0.33 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.02 Pain Relevance 0.73
A role of microglia is suggested by the observation that intrathecal choline suppressed the gp120-induced expression of, cd11b, a macrophage/microglial activation marker.
Negative_regulation (suppressed) of Gene_expression (expression) of cd11b in macrophage associated with intrathecal
7) Confidence 0.31 Published 2010 Journal Brain Behav. Immun. Section Abstract Doc Link 20353818 Disease Relevance 0.89 Pain Relevance 1.45
The inhibitory effect of feG, seen on basal expression of CD11b was not observed in rats that had received an antigen challenge 24 h previously (Figure 3).
Negative_regulation (effect) of Gene_expression (expression) of CD11b
8) Confidence 0.22 Published 2002 Journal BMC Physiol Section Body Doc Link PMC126222 Disease Relevance 0.46 Pain Relevance 0.11
Decreased expression of TLR4 was coincident with decreased expression of the microglial activation markers CD11b (48% in IBCP group; 39% in WBCP group) and CD14 (43%; 30%)(n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Negative_regulation (decreased) of Gene_expression (expression) of CD11b
9) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.44 Pain Relevance 0.50

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