INT66025

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 1
Speculated 4
Reported most in Abstract
Documents 61
Total Number 66
Disease Relevance 31.26
Pain Relevance 26.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
neutrophils 16
microglia 8
leukocyte 6
macrophages 4
striatum 2
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 19 99.96 Very High Very High Very High
cva 24 99.72 Very High Very High Very High
cytokine 151 99.66 Very High Very High Very High
aspirin 37 99.64 Very High Very High Very High
Morphine 494 99.48 Very High Very High Very High
intrathecal 99 99.24 Very High Very High Very High
Inflammation 503 99.20 Very High Very High Very High
Pain 202 99.04 Very High Very High Very High
anesthesia 59 99.02 Very High Very High Very High
nMDA receptor 54 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 40 99.92 Very High Very High Very High
Adhesions 261 99.78 Very High Very High Very High
Diabetes Mellitus 14 99.74 Very High Very High Very High
INFLAMMATION 562 99.72 Very High Very High Very High
Hemorrhage 18 99.72 Very High Very High Very High
Hypertrophy 28 99.30 Very High Very High Very High
Gliosis 86 99.12 Very High Very High Very High
Injury 452 99.10 Very High Very High Very High
Pain 286 99.04 Very High Very High Very High
Bone Cancer 108 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravenous anesthesia inhibits leukocyte-endothelial interactions and expression of CD11b after hemorrhage.
Gene_expression (expression) of CD11b in leukocyte associated with anesthesia and cva
1) Confidence 0.78 Published 2006 Journal Shock Section Title Doc Link 16680014 Disease Relevance 0.39 Pain Relevance 0.47
CD11b/c expression was greater in PMNs of saline treated postreproductive females, than in reproductive or prereproductive animals, but an ET challenge upregulated CD11b/c expression to the same level in all three groups.
Gene_expression (expression) of CD11b in PMNs
2) Confidence 0.75 Published 1996 Journal Inflammation Section Abstract Doc Link 8894713 Disease Relevance 0 Pain Relevance 0.23
We have reported that inactive forms of lansoprazole and omeprazole circulating in the blood suppressed important aspects of the acute inflammatory response, such as the adhesion of neutrophils to the endothelium and extravascular migration of neutrophils, by inhibiting the expression of CD11b/CD18 (a neutrophil adhesion molecule) and by inhibiting IL-8 synthesis in gastric mucosal epithelial cells and endothelial cells [39, 45].
Gene_expression (expression) of CD11b in endothelium associated with inflammatory response and adhesions
3) Confidence 0.75 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 1.28 Pain Relevance 0.22
Inflammation and innate host defense-related responses were assessed via measurements of neutrophil effector responses, i.e., oxygen anion free radical (O2)/eIastase production, CD11b/CD18 expression, apoptosis, and tissue infiltration.
Gene_expression (expression) of CD11b in neutrophil associated with inflammation and apoptosis
4) Confidence 0.75 Published 2005 Journal Shock Section Abstract Doc Link 16374371 Disease Relevance 0.95 Pain Relevance 0.18
In LPS plus ethanol-treated rats gender differences were noted in terms of adhesion molecule (CD11b/c) expression on circulating neutrophils, and cytoskeletal reorganization in blood-recruited neutrophils and Kupffer cells.
Gene_expression (expression) of CD11b in neutrophils associated with adhesions
5) Confidence 0.75 Published 1999 Journal Lupus Section Abstract Doc Link 10455517 Disease Relevance 0.26 Pain Relevance 0.25
CD11b/c expression was greater in PMNs of saline treated postreproductive females, than in reproductive or prereproductive animals, but an ET challenge upregulated CD11b/c expression to the same level in all three groups.
Gene_expression (expression) of CD11b in PMNs
6) Confidence 0.75 Published 1996 Journal Inflammation Section Abstract Doc Link 8894713 Disease Relevance 0 Pain Relevance 0.23
We explored gender differences in phagocytosis by neutrophils (PMNs), CD11b/c expression, generation of cytokine-induced neutrophil chemoattractant (CINC) and the influence of developmental stages on some of these parameters.
Gene_expression (expression) of CD11b in PMNs associated with cytokine
7) Confidence 0.75 Published 1996 Journal Inflammation Section Abstract Doc Link 8894713 Disease Relevance 0 Pain Relevance 0.17
Immunohistochemical experiments revealed that the expression of CD11b, a marker protein of microglia, was increased in the hypothalamus and periaqueductal gray in the chronic constriction injury rat brain as compared with the controls, and memantine treatment could suppress the activation of microglia, suggesting the involvement of microglia in pain mechanism.
Gene_expression (expression) of CD11b in microglia associated with pain, eae, injury and central grey
8) Confidence 0.71 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 19653132 Disease Relevance 1.49 Pain Relevance 1.52
HH3 immunoreactivity (IR), nestin-IR, activated caspase 3-IR, Dcx-IR, CD11b-IR or PECAM-1-IR were revealed using respectively a rabbit anti-HH3 polyclonal antibody (1?
Gene_expression (revealed) of CD11b
9) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.08 Pain Relevance 0.11
Similarly the two groups did not differ in the number of cells stained for the complement type 3 receptor CD11b which labels microglia (Supplementary Figures S4C & S4D, t13?
Gene_expression (stained) of CD11b in microglia
10) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.47 Pain Relevance 0.07
Similarly the two groups did not differ in the number of cells stained for the complement type 3 receptor CD11b which labels microglia (Supplementary Figures S4C & S4D, t13?
Gene_expression (labels) of CD11b in microglia
11) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.47 Pain Relevance 0.07
There were more invading MHC II+ macrophages lacking OX-42(CD11b)/CD4/ED1(CD68) after transection.
Neg (lacking) Gene_expression (lacking) of CD11b in macrophages
12) Confidence 0.65 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17187959 Disease Relevance 0.87 Pain Relevance 0.79
CONCLUSIONS: After hemorrhage, leukocyte adhesion and CD11b expression increased during thiopental anesthesia, but propofol/fentanyl and ketamine protected against hemorrhage-induced leukocyte adhesion.
Gene_expression (expression) of CD11b in leukocyte
13) Confidence 0.60 Published 2006 Journal Shock Section Body Doc Link 16680014 Disease Relevance 0 Pain Relevance 0
The anti-inflammatory effect of ketamine was mediated by direct inhibition of CD11b expression on leukocytes.


Gene_expression (expression) of CD11b in leukocytes
14) Confidence 0.60 Published 2006 Journal Shock Section Body Doc Link 16680014 Disease Relevance 0 Pain Relevance 0
Flow cytometry was also used to determine CD11b expression on neutrophils from blood removed at the end of these experiments (n = 25) or blood incubated with anesthetic agents and activated with platelet activating factor ex vivo (0.1 micromol/L) (n = 24).
Spec (determine) Gene_expression (expression) of CD11b in neutrophils
15) Confidence 0.60 Published 2006 Journal Shock Section Body Doc Link 16680014 Disease Relevance 0.16 Pain Relevance 0
Neutrophils collected from thiopental-treated rats had elevated CD11b expression with thiopental (mean fluorescence baseline, 67.5 +/- 1.3; hemorrhage, 83.6 +/- 5.3; P < 0.05) but not with propofol/fentanyl (mean fluorescence baseline, 69.1 +/- 1.3; hemorrhage, 65.9 +/- 1.6), and ketamine-treated rats (mean fluorescence baseline, 74.3 +/- 2.1; hemorrhage, 74.8 +/- 1.1).
Gene_expression (expression) of CD11b in Neutrophils
16) Confidence 0.60 Published 2006 Journal Shock Section Body Doc Link 16680014 Disease Relevance 0.12 Pain Relevance 0
Hence, this study determined the effects of i.v. anesthesia on leukocyte adhesion after hemorrhage in relation to expression of CD11b.
Gene_expression (expression) of CD11b in leukocyte associated with anesthesia, cva and adhesions
17) Confidence 0.60 Published 2006 Journal Shock Section Abstract Doc Link 16680014 Disease Relevance 0.54 Pain Relevance 0.35
High-dose aspirin also reduced the expression of CD11a, CD11b, and CD18, whereas meloxicam and etanercept did not.
Gene_expression (expression) of CD11a associated with aspirin and etanercept
18) Confidence 0.60 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.01 Pain Relevance 0.72
Following one week of diabetes, neutrophil CD11a, CD11b, and CD18 expression was increased significantly, as were retinal ICAM-1 levels.
Gene_expression (expression) of CD11b in neutrophil associated with diabetes mellitus
19) Confidence 0.60 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.12 Pain Relevance 0.44
High-dose aspirin also reduced the expression of CD11a, CD11b, and CD18, whereas meloxicam and etanercept did not.
Gene_expression (expression) of CD11b associated with aspirin and etanercept
20) Confidence 0.60 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.01 Pain Relevance 0.73

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