INT66026

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 74
Total Number 74
Disease Relevance 31.87
Pain Relevance 23.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
neutrophil 10
neurons 5
macrophages 4
IB4 3
lung 3
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 594 100.00 Very High Very High Very High
chemokine 371 100.00 Very High Very High Very High
metalloproteinase 212 100.00 Very High Very High Very High
Inflammatory mediators 85 100.00 Very High Very High Very High
ischemia 83 100.00 Very High Very High Very High
Inflammatory marker 2 100.00 Very High Very High Very High
Pain 199 99.72 Very High Very High Very High
Chronic pancreatitis 5 99.60 Very High Very High Very High
Inflammation 973 99.40 Very High Very High Very High
acular 10 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1089 100.00 Very High Very High Very High
Cancer 70 100.00 Very High Very High Very High
Necrosis 63 100.00 Very High Very High Very High
Cv General 4 Under Development 11 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 163 99.90 Very High Very High Very High
Pain 218 99.72 Very High Very High Very High
Pancreatitis 6 99.60 Very High Very High Very High
Nociception 192 99.16 Very High Very High Very High
Injury 151 98.96 Very High Very High Very High
Pulmonary Embolism 99 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, carrageenin, LPS and TNF-alpha were shown to stimulate the production of immunoreactive CINC-1 in the skin of injected paws.
Gene_expression (production) of CINC-1 in skin
1) Confidence 0.78 Published 2002 Journal Eur. Cytokine Netw. Section Abstract Doc Link 12517731 Disease Relevance 0.62 Pain Relevance 0.43
Fucoidin had no effect on carrageenan-induced TNF-alpha, IL-1beta, and cytokine-induced neutrophil chemoattractant 1 (CINC-1)/CXCL1 production, suggesting that neutrophils were not the source of hypernociceptive cytokines.
Gene_expression (production) of CXCL1 in neutrophil associated with cytokine
2) Confidence 0.78 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18203872 Disease Relevance 0.44 Pain Relevance 0.31
RESULTS: Anti-inflammatory steroids; dexamethasone, prednisolone and hydrocortisone, dose-dependently inhibited the production of CINC-1, -2 and -3, whose inhibitory patterns were similar to each other.
Gene_expression (production) of CINC
3) Confidence 0.77 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: These results indicate no difference among CINC-1, -2 and -3 in the inhibition of production and mRNA expression of CINCs by anti-inflammatory steroids, although lipopolysaccharide differentially induces expression of each CINC expression in culture of rat macrophages.


Gene_expression (expression) of CINC in macrophages
4) Confidence 0.77 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0 Pain Relevance 0
Expression of each CINC was regulated differently; the production of CINC-1 reached a maximum at 12 h and then slightly decreased after lipopolysaccharide stimulation, whereas that of CINC-2 and CINC-3 increased up to 24 h.
Gene_expression (production) of CINC
5) Confidence 0.77 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0.07 Pain Relevance 0
Furthermore, the increased CINC-1 mRNA expression after administration of indomethacin was also inhibited by treatment with lansoprazole.
Gene_expression (expression) of CINC-1 mRNA
6) Confidence 0.77 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16328016 Disease Relevance 0.51 Pain Relevance 0.24
The results indicate that the appearance of the CINC-related protein is due to impairment of plasma membrane integrity as the consequence of massive cell damage.
Gene_expression (appearance) of CINC-related in plasma
7) Confidence 0.76 Published 1997 Journal Toxicology Section Abstract Doc Link 9230444 Disease Relevance 0.26 Pain Relevance 0.36
Increased productions of both IL-6 and CINC-1 in the exudate were reduced by pretreatment with M-5011 or indomethacin, and TNF levels in the exudate were increased by pretreatment of these drugs.
Gene_expression (productions) of CINC-1
8) Confidence 0.75 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10361883 Disease Relevance 0.66 Pain Relevance 0.38
Thus, M-5011 inhibits the production of both IL-6 and CINC-1 at lower doses than those of indomethacin, and the inhibitory effect of M-5011 on CINC-1, but not IL-6, may partly contribute to the inhibition of leukocyte infiltration in rats with MSU-induced pleurisy.
Gene_expression (production) of CINC-1 in leukocyte associated with pleurisy
9) Confidence 0.75 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10361883 Disease Relevance 0.70 Pain Relevance 0.35
Expression of each CINC was regulated differently; the production of CINC-1 reached a maximum at 12 h and then slightly decreased after lipopolysaccharide stimulation, whereas that of CINC-2 and CINC-3 increased up to 24 h.
Gene_expression (Expression) of CINC
10) Confidence 0.68 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0.07 Pain Relevance 0
and CXCL1/KC but not by IL-1?
Gene_expression (/) of CXCL1
11) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.70 Pain Relevance 0.32
and CXCL1/KC but not by IL-1?
Gene_expression (but) of CXCL1
12) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.71 Pain Relevance 0.32
and CXCL1/KC but not by IL-1?
Gene_expression (by) of CXCL1
13) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.71 Pain Relevance 0.32
and CXCL1/KC but not by IL-1?
Neg (not) Gene_expression (not) of CXCL1
14) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.71 Pain Relevance 0.32
and CXCL1/KC) are involved in caspase-1 mediation of inflammatory hypernociception
Gene_expression (/) of CXCL1 associated with inflammation
15) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.89 Pain Relevance 0.41
and CXCR2 ligands (CXCL1/KC in mice or CINC-1 in rats) and they are activated in the site of inflammation by IL-1?
Gene_expression (/) of CXCL1 associated with inflammation
16) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.47 Pain Relevance 0.24
CONCLUSIONS: These results indicate no difference among CINC-1, -2 and -3 in the inhibition of production and mRNA expression of CINCs by anti-inflammatory steroids, although lipopolysaccharide differentially induces expression of each CINC expression in culture of rat macrophages.


Gene_expression (expression) of CINC in macrophages
17) Confidence 0.60 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0 Pain Relevance 0
Ketorolac (10 mg/kg, intraperitoneally) significantly reduced expression of CINC-1, cyclooxygenase-2, selectin E, and intercellular adhesion molecule 1, lowered neutrophil influx, improved RV function (RV peak systolic pressure was 34 +/- 3 mm Hg; maximum rate of pressure development = 1288 +/- 146; maximum rate of pressure decrease = -611 +/- 92), and marginally reduced cardiac troponin I release (P < 0.07) compared with PE alone.
Gene_expression (expression) of CINC-1 in neutrophil associated with acular, cva and adhesions
18) Confidence 0.59 Published 2009 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 19620882 Disease Relevance 1.04 Pain Relevance 0.89
and CXCL1/KC production and neutrophil recruitment in the paws of WT mice were not different from casp1-/- mice, while the maturation of IL-1?
Gene_expression (production) of CXCL1 in neutrophil
19) Confidence 0.58 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2959021 Disease Relevance 0.67 Pain Relevance 0.32
In addition to sharing such features with the LPBS, the Runx1+ neurons were also found to express Gro/TLE, but not Lmx1b.
Neg (not) Gene_expression (express) of Gro in neurons
20) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.21

General Comments

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