INT66029

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 100
Total Number 105
Disease Relevance 84.28
Pain Relevance 48.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
neutrophil 4
blood 3
liver 3
macrophages 2
peritoneal macrophages 2
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 679 100.00 Very High Very High Very High
cytokine 233 100.00 Very High Very High Very High
antagonist 42 100.00 Very High Very High Very High
Spinal cord 3 100.00 Very High Very High Very High
methotrexate 58 99.98 Very High Very High Very High
Hyperalgesia 45 99.92 Very High Very High Very High
antinociception 1 99.92 Very High Very High Very High
Crohn's disease 16 99.84 Very High Very High Very High
withdrawal 5 99.80 Very High Very High Very High
qutenza 10 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 709 100.00 Very High Very High Very High
Cancer 137 100.00 Very High Very High Very High
Necrosis 121 100.00 Very High Very High Very High
Asthma 67 100.00 Very High Very High Very High
Targeted Disruption 67 100.00 Very High Very High Very High
Nociception 20 100.00 Very High Very High Very High
Hyperalgesia 58 99.92 Very High Very High Very High
Infection 58 99.88 Very High Very High Very High
Disease 137 99.84 Very High Very High Very High
Severe Combined Immunodeficiency 2 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies showed that melatonin, in concentrations ranging from 100 to 1000 nM, suppressed tumor necrosis factor-alpha (TNF-alpha) without affecting the nitric oxide (NO) release in lipopolysaccharides-activated murine peritoneal macrophages.
Negative_regulation (suppressed) of TNF-alpha in peritoneal macrophages associated with necrosis and cancer
1) Confidence 0.59 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10781668 Disease Relevance 1.14 Pain Relevance 0.99
In vitro studies showed that melatonin, in concentrations ranging from 100 to 1000 nM, suppressed tumor necrosis factor-alpha (TNF-alpha) without affecting the nitric oxide (NO) release in lipopolysaccharides-activated murine peritoneal macrophages.
Negative_regulation (suppressed) of tumor necrosis factor-alpha in peritoneal macrophages associated with necrosis and cancer
2) Confidence 0.59 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10781668 Disease Relevance 1.14 Pain Relevance 0.99
Recently, reports have described prevention of hepatic necrosis, induced by other hepato-toxins, by inhibiting tumour necrosis factor alpha (TNFalpha).
Negative_regulation (inhibiting) of TNFalpha associated with necrosis and cancer
3) Confidence 0.58 Published 2000 Journal J. Pathol. Section Abstract Doc Link 10700000 Disease Relevance 0.86 Pain Relevance 0.44
Inhibition of tumour necrosis factor alpha does not prevent experimental paracetamol-induced hepatic necrosis.
Negative_regulation (Inhibition) of tumour necrosis factor alpha associated with necrosis, paracetamol and cancer
4) Confidence 0.58 Published 2000 Journal J. Pathol. Section Title Doc Link 10700000 Disease Relevance 0.90 Pain Relevance 0.51
Recently, reports have described prevention of hepatic necrosis, induced by other hepato-toxins, by inhibiting tumour necrosis factor alpha (TNFalpha).
Negative_regulation (inhibiting) of tumour necrosis factor alpha associated with necrosis and cancer
5) Confidence 0.58 Published 2000 Journal J. Pathol. Section Abstract Doc Link 10700000 Disease Relevance 0.85 Pain Relevance 0.44
Inhibition of TNFalpha does not induce viral reactivation in patients with chronic hepatitis C infection: two cases.
Negative_regulation (Inhibition) of TNFalpha associated with chronic hepatitis and infection
6) Confidence 0.57 Published 2007 Journal Clin. Rheumatol. Section Title Doc Link 16924392 Disease Relevance 1.08 Pain Relevance 0.13
Moreover, the thalidomide pretreatment also reduced the TNF-alpha mRNA levels in the peritoneal cells induced by injection of zymosan in mice.
Negative_regulation (reduced) of TNF-alpha mRNA
7) Confidence 0.57 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10720640 Disease Relevance 0.82 Pain Relevance 0.69
Tumor necrosis factor alpha (TNF-alpha) and myeloperoxidase activity were also strongly inhibited in this model.
Negative_regulation (inhibited) of TNF-alpha associated with necrosis and cancer
8) Confidence 0.57 Published 2007 Journal Life Sci. Section Abstract Doc Link 17490689 Disease Relevance 0.98 Pain Relevance 0.53
In morphine-treated animals, before neutrophil recruitment, a significant decrease in TNF-alpha, IL-1, IL-6, MIP-2, and KC was observed both in bronchoalveolar lavage fluids and in lung tissue.
Negative_regulation (decrease) of TNF-alpha in lung associated with morphine
9) Confidence 0.57 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15611267 Disease Relevance 0.44 Pain Relevance 0.69
Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis.
Negative_regulation (inhibitor) of TNFalpha associated with antagonist, acquired immune deficiency syndrome or hiv infection, severe combined immunodeficiency and encephalitis
10) Confidence 0.57 Published 2001 Journal J. Neuroimmunol. Section Title Doc Link 11240016 Disease Relevance 1.09 Pain Relevance 0.30
There was a significant inhibition of TNF-alpha and NO levels when these drugs were given in combination compared with their effects per se.
Negative_regulation (inhibition) of TNF-alpha
11) Confidence 0.56 Published 2007 Journal Phytother Res Section Abstract Doc Link 17199240 Disease Relevance 0.98 Pain Relevance 0.63
This TNFalpha effect was abolished in mice DRG neurones when DRG cultures were obtained from tnfr1/2-/- and tnfr1-/-, but not from tnfr2-/- mice.
Negative_regulation (abolished) of TNFalpha in DRG associated with dorsal root ganglion
12) Confidence 0.53 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17851089 Disease Relevance 0.96 Pain Relevance 0.56
Meanwhile, cotreatment with ketamine and lipopolysaccharide significantly inhibited lipopolysaccharide-induced TNF-alpha, IL-1beta, and IL-6 mRNA levels.
Negative_regulation (inhibited) of TNF-alpha associated with ketamine
13) Confidence 0.50 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.15 Pain Relevance 0.68
These animals showed a remarked decrease of TNF-alpha bronchoalveolar lavage fluid levels after a single DNS challenge.
Negative_regulation (decrease) of TNF-alpha
14) Confidence 0.50 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11994487 Disease Relevance 0.37 Pain Relevance 0.15
The anti-inflammatory mechanisms of MOR(EtOH) appear to be related to the inhibition of neutrophil infiltration, iNOS and COX-2 protein expression, NO release, and the decreasing TNF-alpha level in serum.
Negative_regulation (decreasing) of TNF-alpha in neutrophil
15) Confidence 0.47 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19576980 Disease Relevance 0 Pain Relevance 0
The description of TB infections with TNFalpha inhibitors led to the establishment of new guidelines for screening patients at high risk of developing TB.
Negative_regulation (inhibitors) of TNFalpha associated with mycobacterial infection and infection
16) Confidence 0.43 Published 2007 Journal Recent patents on inflammation & allergy drug discovery Section Abstract Doc Link 19075965 Disease Relevance 1.57 Pain Relevance 0.42
Resveratrol also decreased the serum TNF-alpha levels and whole brain NO release in a dose-dependent manner.
Neg (NO) Negative_regulation (decreased) of TNF-alpha in brain
17) Confidence 0.43 Published 2007 Journal Fundam Clin Pharmacol Section Abstract Doc Link 17227449 Disease Relevance 1.35 Pain Relevance 0.81
One hour prior to paracetamol injection, mice were also given blocking anti-TNFalpha antibodies, soluble TNFalpha receptor, interleukin 10 (IL-10), and dexamethasone.
Negative_regulation (blocking) of TNFalpha associated with paracetamol and dexamethasone
18) Confidence 0.43 Published 2000 Journal J. Pathol. Section Abstract Doc Link 10700000 Disease Relevance 0.96 Pain Relevance 0.67
Both mechanical and thermal hypernociception following BPA were abolished in tumour necrosis factor alpha (TNFalpha) p55 receptor knockout mice.
Negative_regulation (abolished) of TNFalpha associated with targeted disruption, necrosis and cancer
19) Confidence 0.43 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16386767 Disease Relevance 0.67 Pain Relevance 0.20
Based on these results, it is possible to suggest that therapeutic strategies for blocking TNFalpha could represent a valuable approach for the treatment of persistent neuropathic pain.
Negative_regulation (blocking) of TNFalpha associated with neuropathic pain
20) Confidence 0.43 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16386767 Disease Relevance 0.67 Pain Relevance 0.28

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