INT6603

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Context Info
Confidence 0.29
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 7.88
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA3) plasma membrane (ITGA3)
Anatomy Link Frequency
acinar cells 3
extracellular matrix 1
ITGA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 6 88.32 High High
endometriosis 2 50.00 Quite Low
Dismenorea 2 50.00 Quite Low
anesthesia 2 25.00 Low Low
gABA 2 19.24 Low Low
Dopamine 3 18.80 Low Low
agonist 2 15.96 Low Low
Glutamate 2 15.28 Low Low
ischemia 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 19 99.92 Very High Very High Very High
Pancreatic Cancer 60 99.76 Very High Very High Very High
Nasopharynx Cancer 145 99.40 Very High Very High Very High
Epstein-barr Virus 44 98.32 Very High Very High Very High
Cancer 57 98.08 Very High Very High Very High
Adhesions 39 92.08 High High
Pancreatitis 6 88.32 High High
Dysmenorrhea 2 86.60 High High
Endometriosis (extended) 2 86.00 High High
Malignant Neoplastic Disease 6 13.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemically, VLA alpha 2 and VLA alpha 6 were moderately to strongly expressed on the basal surface of ductal and acinar cells in normal pancreatic tissue, while centro-acinar cells predominantly expressed VLA alpha 3 and VLA alpha 5.
Gene_expression (expressed) of VLA alpha in acinar cells
1) Confidence 0.29 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 0.93 Pain Relevance 0.08
Expression of VLA alpha 3 and VLA alpha 5 in pancreatic carcinoma was heterogeneous, ranging from moderate to weak, and was lost in about 50% of the cells.
Gene_expression (Expression) of VLA alpha associated with pancreatic cancer
2) Confidence 0.29 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 1.37 Pain Relevance 0.07
Immunohistochemically, VLA alpha 2 and VLA alpha 6 were moderately to strongly expressed on the basal surface of ductal and acinar cells in normal pancreatic tissue, while centro-acinar cells predominantly expressed VLA alpha 3 and VLA alpha 5.
Gene_expression (expressed) of VLA alpha in acinar cells
3) Confidence 0.29 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 0.94 Pain Relevance 0.08
Immunohistochemically, VLA alpha 2 and VLA alpha 6 were moderately to strongly expressed on the basal surface of ductal and acinar cells in normal pancreatic tissue, while centro-acinar cells predominantly expressed VLA alpha 3 and VLA alpha 5.
Gene_expression (expressed) of VLA alpha in acinar cells
4) Confidence 0.29 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 0.81 Pain Relevance 0.09
Expression of VLA alpha 3 and VLA alpha 5 in pancreatic carcinoma was heterogeneous, ranging from moderate to weak, and was lost in about 50% of the cells.
Gene_expression (Expression) of VLA alpha associated with pancreatic cancer
5) Confidence 0.29 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 1.31 Pain Relevance 0.07
The redistribution of VLA alpha 2 and VLA alpha 6 may reflect a loss of spatial arrangement of tumor cells and their ability to interact randomly with extracellular matrix structures during invasion and metastasis.
Gene_expression (redistribution) of VLA alpha in extracellular matrix associated with cancer and metastasis
6) Confidence 0.25 Published 1992 Journal Int. J. Cancer Section Abstract Doc Link 1330937 Disease Relevance 1.20 Pain Relevance 0.07
The microarray gene expression analysis of these cells indicates that the cells are negative for the hematopoietic markers CD34, CD49c, CD49d, CD62e, CD62p, CD106, CD117, CD133, CD235a, HLA-DRB4, HLA-DRB4 and HAS1, and positive for the mesenchymal markers CD13, CD29, CD44, CD49a/b, CD49e, CD73, CD105 and vimentin [18], supporting their USSCs/MSC origin.
Neg (negative) Gene_expression (negative) of CD49c
7) Confidence 0.25 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
Dynamic detection of serum sialic acid and VCA-IgA might be a valuable technique for diagnosis and monitoring radiotherapy effectiveness in NPC patients.
Gene_expression (detection) of VCA associated with nasopharynx cancer
8) Confidence 0.05 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.16 Pain Relevance 0
The samples were immunohistochemically examined for the expression of very late activation antigen-2 (VLA-2), VLA-3, VLA-4, VLA-5, VLA-6, and E-cadherin.
Spec (examined) Gene_expression (expression) of VLA-3
9) Confidence 0.02 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Body Doc Link 9392916 Disease Relevance 0.17 Pain Relevance 0
Expressed as percentage of the maximum 'inherent VCA', the maximum 'stimulation VCA' was 116 +/- 7 and 41 +/- 8%, respectively.
Gene_expression (Expressed) of VCA
10) Confidence 0.00 Published 1995 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 7594206 Disease Relevance 0 Pain Relevance 0
Expressed as percentage of the maximum 'inherent VCA', the maximum 'stimulation VCA' was 116 +/- 7 and 41 +/- 8%, respectively.
Gene_expression (Expressed) of VCA
11) Confidence 0.00 Published 1995 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 7594206 Disease Relevance 0 Pain Relevance 0

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