INT66038

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 26.07
Pain Relevance 11.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
plasma membrane (Ngfr) nucleus (Ngfr) cytoplasm (Ngfr)
Anatomy Link Frequency
brain 3
neurite 2
endocrine pancreas 1
sensory neurons 1
apoptotic cell 1
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
Hsan 3 100.00 Very High Very High Very High
cINOD 71 99.98 Very High Very High Very High
Calcitonin gene-related peptide 6 99.90 Very High Very High Very High
Chronic pancreatitis 40 99.84 Very High Very High Very High
cytokine 86 99.64 Very High Very High Very High
Central nervous system 112 99.54 Very High Very High Very High
dorsal root ganglion 7 99.44 Very High Very High Very High
Nerve growth factor 162 98.98 Very High Very High Very High
Peripheral nerve injury 1 98.98 Very High Very High Very High
TRP channel 1 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1267 100.00 Very High Very High Very High
Cancer 51 100.00 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 3 100.00 Very High Very High Very High
Familial Dysautonomia 1 100.00 Very High Very High Very High
Disease 1321 99.84 Very High Very High Very High
Pancreatitis 40 99.84 Very High Very High Very High
Stomach Cancer 36 99.80 Very High Very High Very High
Death 536 99.74 Very High Very High Very High
Injury 146 99.68 Very High Very High Very High
Metastasis 19 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CGRP and p75 NTR immunoreactivity in the L5 DRG neurons was upregulated in the injured nerve groups compared with the sham-operated group; however, p75 NTR inhibitory antibody decreased the CGRP and p75 NTR expression (p < 0.01).
Positive_regulation (upregulated) of p75 in nerve associated with calcitonin gene-related peptide
1) Confidence 0.69 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.57 Pain Relevance 1.04
Up-regulation of p75 neurotrophin receptor (p75NTR) is associated with apoptosis in chronic pancreatitis.
Positive_regulation (Up-regulation) of p75 neurotrophin receptor associated with apoptosis and chronic pancreatitis
2) Confidence 0.68 Published 2003 Journal Dig. Dis. Sci. Section Title Doc Link 12741461 Disease Relevance 1.00 Pain Relevance 0.51
By northern blot analysis, p75NTR mRNA levels were increased 40-fold in chronic pancreatitis compared with normal pancreas (P < 0.01).
Positive_regulation (increased) of p75NTR in pancreas associated with chronic pancreatitis
3) Confidence 0.68 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12741461 Disease Relevance 1.00 Pain Relevance 0.54
In conclusion, p75NTR, the low-affinity receptor of neurotrophins which mediates apoptosis, is up-regulated in CP and is involved in the apoptotic process of the exocrine and endocrine pancreas.
Positive_regulation (up-regulated) of p75NTR in endocrine pancreas associated with apoptosis
4) Confidence 0.68 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12741461 Disease Relevance 1.03 Pain Relevance 0.53
Up-regulation of p75 neurotrophin receptor (p75NTR) is associated with apoptosis in chronic pancreatitis.
Positive_regulation (Up-regulation) of p75NTR associated with apoptosis and chronic pancreatitis
5) Confidence 0.68 Published 2003 Journal Dig. Dis. Sci. Section Title Doc Link 12741461 Disease Relevance 1.00 Pain Relevance 0.52
Our results show that p75NTR induced in undamaged DRG neurons facilitates TrkA signaling and contributes to heat and cold hyperalgesia.
Positive_regulation (induced) of p75NTR in neurons associated with dorsal root ganglion, hyperalgesia and cold hyperalgesia
6) Confidence 0.64 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17108171 Disease Relevance 1.12 Pain Relevance 0.62
R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction.
Positive_regulation (induction) of p75 associated with stomach cancer and metastasis
7) Confidence 0.62 Published 2010 Journal Mol. Pharm. Section Title Doc Link 19916560 Disease Relevance 1.42 Pain Relevance 0.43
The anticancer effects of R-flurbiprofen were found to require induction of p75(NTR) via the p38 signaling pathway, suggesting a possible mechanism of action.
Positive_regulation (induction) of p75
8) Confidence 0.62 Published 2010 Journal Mol. Pharm. Section Abstract Doc Link 19916560 Disease Relevance 1.27 Pain Relevance 0.21
Higher p75NTR protein levels could be confirmed by western blot analysis, which revealed an 8.6-fold increase of p75NTR in chronic pancreatitis.
Positive_regulation (increase) of p75NTR associated with chronic pancreatitis
9) Confidence 0.60 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12741461 Disease Relevance 1.21 Pain Relevance 0.73
Using neurophysiological recording techniques, we now show that p75 is not required for the survival of specific, functionally defined subpopulations of sensory neurons.
Neg (not) Positive_regulation (required) of p75 in sensory neurons
10) Confidence 0.50 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9151756 Disease Relevance 0.27 Pain Relevance 0.17
Following a peripheral nerve injury, brain-derived neurotrophic factor (BDNF) and the p75 neurotrophin receptor are upregulated in Schwann cells of the Wallerian degenerating nerves.
Positive_regulation (upregulated) of p75 neurotrophin receptor in Schwann cells associated with nervous system injury and peripheral nerve injury
11) Confidence 0.44 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11122329 Disease Relevance 0.18 Pain Relevance 0.09
Consistent with reports on other cancer cell types, NSAID treatment with R-flurbiprofen increased levels of the tumor suppressor neurotrophin receptor (p75(NTR)) in gastric cancer cells.
Positive_regulation (increased) of p75 associated with cancer, cinod and stomach cancer
12) Confidence 0.42 Published 2010 Journal Mol. Pharm. Section Abstract Doc Link 19916560 Disease Relevance 1.47 Pain Relevance 0.34
Consistent with reports on other cancer cell types, NSAID treatment with R-flurbiprofen increased levels of the tumor suppressor neurotrophin receptor (p75(NTR)) in gastric cancer cells.
Positive_regulation (increased) of neurotrophin receptor associated with cancer, cinod and stomach cancer
13) Confidence 0.42 Published 2010 Journal Mol. Pharm. Section Abstract Doc Link 19916560 Disease Relevance 1.47 Pain Relevance 0.34
In agreement with previous observations, these axons were also positive for the p75 receptor and GAP-43 (Risling et al., 1994).
Positive_regulation (positive) of p75 receptor
14) Confidence 0.42 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3008941 Disease Relevance 0.19 Pain Relevance 0.28
These observations suggest that p75NTR is an important upstream modulator of the anticancer effects of NSAIDs and that ibuprofen induction of the p75NTR protein establishes an alternate mechanism by which ibuprofen may exert an anticancer effect.
Positive_regulation (induction) of p75NTR associated with cinod
15) Confidence 0.33 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15342406 Disease Relevance 0.51 Pain Relevance 0.57
To examine a mechanistic relationship between ibuprofen induction of p75NTR protein and inhibition of survival, bladder cancer cells were transfected with ponasterone A-inducible vectors that expressed a death domain-deleted (DeltaDD) or intracellular domain-deleted (DeltaICD) p75NTR product that acts as a dominant negative antagonist of the intact p75NTR protein.
Spec (examine) Positive_regulation (induction) of p75NTR in bladder associated with antagonist, bladder cancer and death
16) Confidence 0.33 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15342406 Disease Relevance 0.84 Pain Relevance 1.00
In contrast, treatment with BDNF activates neuronal p75NTR, inducing the release of ACh and significantly slowing the rate of myocyte contraction [194].
Positive_regulation (activates) of p75NTR in neuronal
17) Confidence 0.32 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.06 Pain Relevance 0
Rho activation by outgrowth inhibitors such as MAG and Nogo is mediated through p75NTR, which enhances the dissociation of the Rho-guanine nucleotide dissociation inhibitor (Rho-GDI) from RhoA after stimulation by the neurite outgrowth inhibitors (Yamashita and Tohyama 2003).
Positive_regulation (activation) of p75NTR in neurite
18) Confidence 0.31 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.13 Pain Relevance 0.11
This rank order NSAID induction of the p75NTR protein correlated with the ability of these NSAIDs to reduce cancer cell survival.
Positive_regulation (induction) of p75NTR associated with cancer and cinod
19) Confidence 0.29 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15342406 Disease Relevance 0.84 Pain Relevance 1.00
Rho activation by outgrowth inhibitors such as MAG and Nogo is mediated through p75NTR, which enhances the dissociation of the Rho-guanine nucleotide dissociation inhibitor (Rho-GDI) from RhoA after stimulation by the neurite outgrowth inhibitors (Yamashita and Tohyama 2003).
Positive_regulation (mediated) of p75NTR in neurite
20) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.12 Pain Relevance 0.10

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