INT66039

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 53
Total Number 56
Disease Relevance 15.87
Pain Relevance 17.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
brain 11
neurons 5
neuronal 3
sciatic nerve 3
nerve 2
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hsan 3 100.00 Very High Very High Very High
antidepressant 769 99.82 Very High Very High Very High
agonist 420 99.72 Very High Very High Very High
trigeminal ganglion 225 99.70 Very High Very High Very High
Spinal cord 22 99.68 Very High Very High Very High
GABAergic 10 99.64 Very High Very High Very High
Eae 152 99.50 Very High Very High Very High
monoamine 54 99.40 Very High Very High Very High
Serotonin 31 99.28 Very High Very High Very High
fluoxetine 112 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 3 100.00 Very High Very High Very High
Familial Dysautonomia 1 100.00 Very High Very High Very High
Ganglion Cysts 460 99.70 Very High Very High Very High
Targeted Disruption 420 99.48 Very High Very High Very High
Shock 161 98.74 Very High Very High Very High
Anxiety Disorder 544 98.54 Very High Very High Very High
Neurodegenerative Disease 112 98.40 Very High Very High Very High
Apoptosis 404 98.32 Very High Very High Very High
Neuropathic Pain 5 98.08 Very High Very High Very High
Depression 687 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice overexpressing the full-length trkB receptor (TrkB.TK+) and showing increased trkB activity in brain, and their wild type (WT) littermates, were injected with the antidepressant fluoxetine or saline, and analyzed behaviorally in the forced swimming test paradigm and biochemically for the concentrations of brain monoamines and their metabolites. 4.
Positive_regulation (increased) of trkB in brain associated with targeted disruption, antidepressant, monoamine and fluoxetine
1) Confidence 0.69 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16392030 Disease Relevance 0.19 Pain Relevance 0.50
These data, together with other recent observations, suggest that trkB activation may play a critical role in the behavioral responses to antidepressant drugs in mice.
Positive_regulation (activation) of trkB associated with antidepressant
2) Confidence 0.69 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16392030 Disease Relevance 0.21 Pain Relevance 0.52
Finally, brain monoamines seem to be critical mediators of antidepressant-induced TrkB activation, as antidepressants reboxetine and citalopram do not produce TrkB activation in the brains of serotonin- or norepinephrine-depleted mice.
Neg (not) Positive_regulation (activation) of TrkB in brains associated with antidepressant, serotonin and monoamine
3) Confidence 0.69 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.64
Finally, brain monoamines seem to be critical mediators of antidepressant-induced TrkB activation, as antidepressants reboxetine and citalopram do not produce TrkB activation in the brains of serotonin- or norepinephrine-depleted mice.
Positive_regulation (activation) of TrkB in brains associated with antidepressant, serotonin and monoamine
4) Confidence 0.69 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.73
In conclusion, our data suggest that rapid activation of the TrkB neurotrophin receptor and PLCgamma1 signaling is a common mechanism for all antidepressant drugs.
Positive_regulation (activation) of TrkB associated with antidepressant
5) Confidence 0.69 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.61
In the present study, we have further examined the biochemical and functional characteristics of antidepressant-induced TrkB activation in vivo.
Spec (examined) Positive_regulation (activation) of TrkB associated with antidepressant
6) Confidence 0.69 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.49
We show that all the antidepressants examined, including inhibitors of monoamine transporters and metabolism, activate TrkB rapidly in the rodent anterior cingulate cortex and hippocampus.
Spec (examined) Positive_regulation (activate) of TrkB in hippocampus associated with antidepressant, hippocampus, anterior cingulate cortex and monoamine
7) Confidence 0.69 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.58
RT-PCR analysis revealed no change of TrkA or TrkB in mouse brain upon deoxygedunin treatment (Figure S2B), indicating that deoxygedunin stimulates TrkB activation independent of Trk receptor transcriptional alteration.
Positive_regulation (activation) of TrkB in brain
8) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
TrkB was selectively phosphorylated in the brain 2 h after injection, and peaked at 4–8 h, so was the downstream effectors Akt and Erk1/2 activation (Figure 2E, left panels), suggesting that deoxygedunin can penetrate the brain-blood barrier and stimulate TrkB activation.
Positive_regulation (activation) of TrkB in brain
9) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Hence, deoxygedunin can strongly trigger TrkB activation in vitro and in vivo.


Positive_regulation (activation) of TrkB
10) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
The positive gedunin derivatives elicited TrkB activation in rat hippocampal neurons (Figure 2A).
Positive_regulation (activation) of TrkB in neurons
11) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.40 Pain Relevance 0.03
Pretreatment of K252a substantially blocked deoxygedunin-triggered TrkB activation in cortical neurons (Figure 2D), indicating that deoxygedunin can provoke TrkB autophosphorylation.
Positive_regulation (activation) of TrkB in neurons
12) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.06 Pain Relevance 0
In the present study, we further demonstrated that the increased in the protein level of full-length TrkB is completely reversed by concomitant intrathecal injection of BDNF antibody.
Positive_regulation (increased) of TrkB associated with intrathecal
13) Confidence 0.69 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470870 Disease Relevance 0.55 Pain Relevance 0.76
We previously reported that protein level of full-length TrkB, which contains the cytoplasmic protein tyrosine kinase domain, were clearly increased on the ipsilateral side of spinal cord membranes obtained from sciatic nerve-ligated mice.
Positive_regulation (increased) of TrkB in sciatic nerve associated with sciatic nerve and spinal cord
14) Confidence 0.69 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470870 Disease Relevance 0.50 Pain Relevance 0.70
These studies suggest that the behavioral effect of antidepressants requires TrkB activation along with an increase in BDNF expression.
Positive_regulation (activation) of TrkB associated with antidepressant
15) Confidence 0.66 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.37 Pain Relevance 0.56
It has been shown that long-term treatment with electro-convulsive shock, desipramine, fluoxetine, tranylcypromine, and sertraline all increased mRNA levels of TrkB in the rat brain.98 Recently, Rantamäki et al131,132 reported that not only the expression, but TrkB signaling, is rapidly activated by a variety of antidepressants in mouse medial prefrontal cortex (PFC) and hippocampus.
Positive_regulation (activated) of TrkB in cortex associated with antidepressant, desipramine, shock, hippocampus and fluoxetine
16) Confidence 0.66 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.30 Pain Relevance 0.43
It has been shown that long-term treatment with electro-convulsive shock, desipramine, fluoxetine, tranylcypromine, and sertraline all increased mRNA levels of TrkB in the rat brain.98 Recently, Rantamäki et al131,132 reported that not only the expression, but TrkB signaling, is rapidly activated by a variety of antidepressants in mouse medial prefrontal cortex (PFC) and hippocampus.
Positive_regulation (increased) of TrkB in cortex associated with antidepressant, desipramine, shock, hippocampus and fluoxetine
17) Confidence 0.66 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.29 Pain Relevance 0.38
In Brn3a-/- embryos at E13.5, TrkB is increased relative to controls (Figure 4J) and TrkC is nearly undetectable (Figure 4J, L).
Positive_regulation (increased) of TrkB in embryos
18) Confidence 0.66 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.29 Pain Relevance 0.10
Our results suggest that mature BDNF decreases the excitability of GABAergic interneurons via activation of TrkB, while proBDNF does not impact on GABAergic activity.
Positive_regulation (activation) of TrkB in interneurons associated with gabaergic
19) Confidence 0.64 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19812317 Disease Relevance 0 Pain Relevance 0.49
Brain-derived neurotrophic factor (BDNF) influences the growth and plasticity of serotonergic (5-HT) neurons via the activation of trkB receptor. 3.
Positive_regulation (activation) of trkB in neurons
20) Confidence 0.50 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16392030 Disease Relevance 0.19 Pain Relevance 0.47

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