INT66041

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 16.12
Pain Relevance 8.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
nerve 2
neuronal 1
neurons 1
pancreas 1
masseter 1
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 65 100.00 Very High Very High Very High
Hsan 53 100.00 Very High Very High Very High
nociceptor 11 99.44 Very High Very High Very High
intrathecal 1 99.20 Very High Very High Very High
nMDA receptor 3 97.00 Very High Very High Very High
Peripheral sensitization 1 96.08 Very High Very High Very High
qutenza 3 94.32 High High
Spinal cord 4 94.16 High High
allodynia 2 91.48 High High
long-term potentiation 1 88.56 High High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 669 100.00 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 53 100.00 Very High Very High Very High
Familial Dysautonomia 1 100.00 Very High Very High Very High
Uniparental Disomy 6 99.24 Very High Very High Very High
Cancer 297 99.20 Very High Very High Very High
Neuroma 4 99.00 Very High Very High Very High
Thyroid Nodule 9 98.08 Very High Very High Very High
Nociception 1 97.32 Very High Very High Very High
Paraneoplastic Syndromes 1 97.24 Very High Very High Very High
Disease 160 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constitutive activation of NTRK1 has been detected in several tumor types.
Positive_regulation (activation) of NTRK1 associated with cancer
1) Confidence 0.70 Published 2006 Journal Cancer Lett. Section Abstract Doc Link 16242838 Disease Relevance 0.71 Pain Relevance 0.10
Similarly, the mutation abolished the constitutive activation of the TRK-T3 oncogene.
Positive_regulation (activation) of TRK-T3 oncogene
2) Confidence 0.69 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.56 Pain Relevance 0.64
We reported that TRKA is the gene responsible for CIPA and we developed a comprehensive strategy to screen for TRKA mutations and polymorphisms, as based on the gene's structure and organization.
Positive_regulation (responsible) of TRKA associated with hsan
3) Confidence 0.69 Published 2001 Journal Hum. Mutat. Section Abstract Doc Link 11668614 Disease Relevance 0.89 Pain Relevance 0.54
Activation of trk receptors enhances the response of the vanilloid VR-1 receptor in nociceptive neurons leading to peripheral sensitization of the response to capsaicin or noxious heat.
Positive_regulation (Activation) of trk in neurons associated with nociception, qutenza and peripheral sensitization
4) Confidence 0.67 Published 2002 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 12589921 Disease Relevance 0.10 Pain Relevance 0.31
RESULTS: Northern blot analysis indicated that NGF and TrkA mRNA levels were increased 2.7-fold and 5.6-fold, respectively (P <.05 and P <.05), in pancreatic cancer tissues compared with the normal pancreas tissue.
Positive_regulation (increased) of TrkA in pancreas
5) Confidence 0.61 Published 1999 Journal J. Clin. Oncol. Section Body Doc Link 10561305 Disease Relevance 0.16 Pain Relevance 0
We found that Brn3a required HCF for activating the trkA promoter and Zhangfei suppressed its activity in non-neuronal cells.
Positive_regulation (activating) of trkA in neuronal
6) Confidence 0.56 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.38 Pain Relevance 0.29
Oncogenic rearrangements of the NTRK1/NGF receptor.
Positive_regulation (rearrangements) of NTRK1
7) Confidence 0.50 Published 2006 Journal Cancer Lett. Section Title Doc Link 16242838 Disease Relevance 0.64 Pain Relevance 0.09
Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes.
Positive_regulation (designated) of TRKA
8) Confidence 0.50 Published 1997 Journal Jpn. J. Hum. Genet. Section Abstract Doc Link 9290260 Disease Relevance 0.27 Pain Relevance 0.35
Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes.
Positive_regulation (designated) of NTRK1
9) Confidence 0.50 Published 1997 Journal Jpn. J. Hum. Genet. Section Abstract Doc Link 9290260 Disease Relevance 0.27 Pain Relevance 0.35
The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor.
Positive_regulation (inactivation) of NTRK1 in nerve associated with nerve growth factor and hsan
10) Confidence 0.50 Published 2000 Journal J. Cell. Physiol. Section Title Doc Link 10567924 Disease Relevance 0.61 Pain Relevance 0.70
Our results demonstrate clearly that the CIPA mutations cause the inactivation of the NTRK1 receptor, thus exerting a loss of function effect, and provide an experimental approach to distinguish functional mutations from genetic polymorphisms.
Positive_regulation (inactivation) of NTRK1 receptor associated with hsan
11) Confidence 0.50 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.53 Pain Relevance 0.60
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
Positive_regulation (mutations) of TRKA associated with uniparental disomy and hsan
12) Confidence 0.50 Published 2001 Journal Hum. Mutat. Section Title Doc Link 11668614 Disease Relevance 0.95 Pain Relevance 0.57
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
Positive_regulation (mutations) of NTRK1 associated with uniparental disomy and hsan
13) Confidence 0.50 Published 2001 Journal Hum. Mutat. Section Title Doc Link 11668614 Disease Relevance 0.95 Pain Relevance 0.57
K252a (10-100 nm), BAPTA-AM (25 microm), and Cd(2+) (200 microm) prevented NGF enhancement of ACh release, suggesting the involvement of TrkA receptors, Ca(2+), and voltage-gated Ca(2+) channels, respectively.
Positive_regulation (involvement) of TrkA associated with nerve growth factor
14) Confidence 0.49 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11331367 Disease Relevance 0 Pain Relevance 0.59
The segregation of polymorphic alleles at and around loci for p75NGFR, TRKA, TRKB, BDNF, and familial dysautonomia (another hereditary sensory neuropathy having features in common with HSN II) virtually excluded these genes as the cause of HSN II in this family.
Positive_regulation (cause) of TRKA associated with familial dysautonomia and hsan
15) Confidence 0.49 Published 1996 Journal Pain Section Abstract Doc Link 8895241 Disease Relevance 0.57 Pain Relevance 0.40
We recently found that the activated nerve growth factor (NGF) receptor p-TrkA is more frequently expressed compared to p75, another NGF receptor that belongs to the tumor necrosis factor family, in MM, and that p-TrkA expression is significantly higher in peritoneal MM compared to their pleural counterparts (Figures 1-D, 1-E).
Positive_regulation (activated) of TrkA in nerve associated with necrosis, lung cancer, nerve growth factor and cancer
16) Confidence 0.45 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.95 Pain Relevance 0.15
Semiquantitative image analysis showed a significantly increased trkA immunoreactivity in the neuroma group.
Positive_regulation (increased) of trkA associated with neuroma
17) Confidence 0.43 Published 2002 Journal Muscle Nerve Section Abstract Doc Link 11932982 Disease Relevance 0.35 Pain Relevance 0.05
Furthermore, increased NGF/TrkA expression levels were associated with a higher degree of pain (P <. 01).
Positive_regulation (increased) of TrkA
18) Confidence 0.41 Published 1999 Journal J. Clin. Oncol. Section Body Doc Link 10561305 Disease Relevance 0.11 Pain Relevance 0
Since MTC is derived from the diffuse neuroendocrine system, patients may present with a paraneoplastic syndrome resulting in diarrhea and abdominal cramping as a result of prostaglandin and vasoactive peptide release.
Positive_regulation (derived) of MTC associated with thyroid neoplasm, diarrhoea and paraneoplastic syndromes
19) Confidence 0.31 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 2.07 Pain Relevance 0.05
These findings indicate that human NGF-induced sensitization of masseter nociceptors results, in part, from the activation of TrkA receptors, but does not appear to be mediated through enhanced peripheral NMDA receptor activity.
Positive_regulation (activation) of TrkA in masseter associated with nerve growth factor, nmda receptor and nociceptor
20) Confidence 0.21 Published 2010 Journal Pain Section Abstract Doc Link 20064691 Disease Relevance 0.13 Pain Relevance 1.03

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