INT66043

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Context Info
Confidence 0.44
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.62
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SPTLC2) small molecule metabolic process (SPTLC2) endoplasmic reticulum (SPTLC2)
biosynthetic process (SPTLC2) transferase activity, transferring acyl groups (SPTLC2)
SPTLC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 100 96.56 Very High Very High Very High
Nerve growth factor 4 92.88 High High
Pain 6 82.96 Quite High
imagery 2 5.00 Very Low Very Low Very Low
unmyelinated 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
lancinating pain 1 5.00 Very Low Very Low Very Low
syringomyelia 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
diabetic neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Neuropathy 1 99.72 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 107 96.56 Very High Very High Very High
Familial Dysautonomia 2 87.36 High High
Pain 7 82.96 Quite High
Osteoarthritis 2 81.80 Quite High
Neuropathic Pain 15 81.04 Quite High
Repression 1 70.88 Quite High
Disease 24 11.60 Low Low
Syndrome 7 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serine palmitoyltransferase (SPT) is a pyridoxal-5'-phosphate dependent enzyme, which is suggested to be a key enzyme for the regulation of sphingolipid levels in cells.
Regulation (regulation) of Serine palmitoyltransferase
1) Confidence 0.44 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2311280 Disease Relevance 0.63 Pain Relevance 0.40
Further evaluation of loci for other neurotrophic factors and their receptors, which will be possible when mapping information on their loci becomes available, may permit the identification of the gene responsible for HSN II.
Regulation (responsible) of HSN II
2) Confidence 0.11 Published 1996 Journal Pain Section Abstract Doc Link 8895241 Disease Relevance 0.43 Pain Relevance 0.29
In this study candidate genes were evaluated by their inheritance pattern in two sisters affected with HSN II, their unaffected sister and mother in a consanguineous family.
Regulation (affected) of HSN II
3) Confidence 0.11 Published 1996 Journal Pain Section Abstract Doc Link 8895241 Disease Relevance 0.56 Pain Relevance 0.40

General Comments

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