INT66047

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2007
Negated 1
Speculated 3
Reported most in Abstract
Documents 2
Total Number 7
Disease Relevance 3.36
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
pituitary 4
visceral 2
spinal cord 2
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 3 100.00 Very High Very High Very High
amygdala 246 99.98 Very High Very High Very High
Inflammation 6 99.92 Very High Very High Very High
allodynia 3 97.48 Very High Very High Very High
Neuropeptide 19 95.64 Very High Very High Very High
qutenza 1 95.44 Very High Very High Very High
interstitial cystitis 3 94.52 High High
Spinal cord 2 93.24 High High
Dorsal horn 10 85.52 High High
Calcitonin gene-related peptide 5 81.68 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 3 100.00 Very High Very High Very High
INFLAMMATION 6 99.92 Very High Very High Very High
Overactive Bladder 6 99.80 Very High Very High Very High
Cystitis 15 99.72 Very High Very High Very High
Neuropathic Pain 3 97.48 Very High Very High Very High
Shock 162 96.48 Very High Very High Very High
Abnormal Reflex 3 96.12 Very High Very High Very High
Syndrome 3 94.92 High High
Interstitial Cystitis 3 94.52 High High
Anxiety Disorder 117 84.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present report we have examined the effect of sciatic nerve injury (unilateral transection) on PACAP expression (immunocytochemistry, radioimmunoassay, in situ hybridization and northern blot analysis) in dorsal root ganglia at the lumbar level and on immunoreactive PACAP in the spinal cord and in the sciatic nerve stump.
Spec (examined) Regulation (effect) of Gene_expression (expression) of PACAP in spinal cord associated with nervous system injury, sciatic nerve and spinal cord
1) Confidence 0.58 Published 1996 Journal Neuroscience Section Abstract Doc Link 8895878 Disease Relevance 0.17 Pain Relevance 0.34
These studies examined changes in the expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in micturition reflex pathways after chronic cystitis induced by cyclophosphamide (CYP).
Spec (examined) Regulation (changes) of Gene_expression (expression) of PACAP in pituitary associated with cystitis and overactive bladder
2) Confidence 0.45 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.40 Pain Relevance 0.04
These studies examined changes in the expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in micturition reflex pathways after chronic cystitis induced by cyclophosphamide (CYP).
Spec (examined) Regulation (changes) of Gene_expression (expression) of pituitary adenylate cyclase-activating polypeptide in pituitary associated with cystitis and overactive bladder
3) Confidence 0.45 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.39 Pain Relevance 0.04
densities of specific PACAP receptor (PAC1-R) expression were detected in
Regulation (densities) of Gene_expression (expression) of PACAP
4) Confidence 0.44 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.49 Pain Relevance 0.40
Intra-CeA PACAP injection does not alter exploration of the
Neg (not) Regulation (alter) of Gene_expression (injection) of PACAP associated with amygdala
5) Confidence 0.38 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.50 Pain Relevance 0.34
No intra-CeA PACAP injection effects were found in animals tested with the
Regulation (effects) of Gene_expression (injection) of PACAP associated with amygdala
6) Confidence 0.38 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.46 Pain Relevance 0.35
Changes in PACAP expression after cystitis may play a role in altered visceral sensation (allodynia) and/or urinary bladder hyperreflexia in the clinical syndrome, interstitial cystitis.
Regulation (Changes) of Gene_expression (expression) of PACAP in visceral associated with allodynia, syndrome, abnormal reflex, cystitis and interstitial cystitis
7) Confidence 0.23 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.94 Pain Relevance 0.33

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