INT66048

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 8.21
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
visceral 2
nerve 2
neurons 2
pituitary 2
bladder 2
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 574 100.00 Very High Very High Very High
Neuropeptide 34 100.00 Very High Very High Very High
Inflammation 9 99.92 Very High Very High Very High
withdrawal 42 99.16 Very High Very High Very High
allodynia 2 97.48 Very High Very High Very High
Dorsal horn 12 96.72 Very High Very High Very High
Eae 8 96.44 Very High Very High Very High
Spinal cord 2 95.20 Very High Very High Very High
dorsal root ganglion 3 94.96 High High
interstitial cystitis 2 94.52 High High
Disease Link Frequency Relevance Heat
Cystitis 10 99.96 Very High Very High Very High
INFLAMMATION 9 99.92 Very High Very High Very High
Injury 11 99.62 Very High Very High Very High
Shock 378 99.24 Very High Very High Very High
Anxiety Disorder 273 98.12 Very High Very High Very High
Neuropathic Pain 3 97.48 Very High Very High Very High
Urological Neuroanatomy 9 96.16 Very High Very High Very High
Abnormal Reflex 2 96.12 Very High Very High Very High
Ganglion Cysts 3 94.96 High High
Syndrome 2 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infusion of PACAP into CeA resulted in no
Neg (no) Positive_regulation (resulted) of Gene_expression (Infusion) of PACAP associated with amygdala
1) Confidence 0.49 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.75 Pain Relevance 0.33
Since strikingly high local concentrations of PACAP immunopositive nerve fibers
Positive_regulation (concentrations) of Gene_expression (concentrations) of PACAP in nerve
2) Confidence 0.49 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.44 Pain Relevance 0.34
There were indications of axotomy-induced expression of PACAP messenger RNA in larger neurons.
Positive_regulation (axotomy-induced) of Gene_expression (expression) of PACAP in neurons
3) Confidence 0.47 Published 1996 Journal Neuroscience Section Abstract Doc Link 8895878 Disease Relevance 0.20 Pain Relevance 0.63
Changes in PACAP expression after cystitis may play a role in altered visceral sensation (allodynia) and/or urinary bladder hyperreflexia in the clinical syndrome, interstitial cystitis.
Positive_regulation (Changes) of Gene_expression (expression) of PACAP in visceral associated with allodynia, syndrome, abnormal reflex, cystitis and interstitial cystitis
4) Confidence 0.43 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.94 Pain Relevance 0.33
After chronic cystitis, PACAP immunoreactivity in cells in the L1, L2, L6, and S1 DRG increased significantly (P </= 0.0001), and the percentage of bladder afferent cells expressing PACAP immunoreactivity also increased significantly (P </= 0.0001; 70-85%).
Positive_regulation (increased) of Gene_expression (immunoreactivity) of PACAP in bladder associated with cystitis
5) Confidence 0.43 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.69 Pain Relevance 0.28
Seven days following injury, the incidence of expression of the neuropeptides galanin and pituitary adenylate cyclase-activating polypeptide (PACAP) was increased in L5 sensory neurons ipsilateral to the injury from 12% to 60% and 16% to 37% respectively, in addition to an increased level of expression.
Positive_regulation (increased) of Gene_expression (expression) of PACAP in pituitary associated with injury and neuropeptide
6) Confidence 0.43 Published 2006 Journal Neuroscience Section Abstract Doc Link 16843605 Disease Relevance 1.21 Pain Relevance 0.98
Intra-CeA PACAP injection does not alter exploration of the
Positive_regulation (-) of Gene_expression (injection) of PACAP associated with amygdala
7) Confidence 0.43 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.50 Pain Relevance 0.34
Indeed, our results indicated that intra-CeA microinfusion of PACAP (50 or 100 pmol) enhanced certain types of aversive behaviors in the shock-probe fear test, consistent with our notion that PACAPergic neurotransmission may be linked to manifestations of stress and fear

(Agarwal et al. [8];

Positive_regulation (enhanced) of Gene_expression (microinfusion) of PACAP associated with stress, anxiety disorder, shock and amygdala
8) Confidence 0.43 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 1.32 Pain Relevance 0.29
velocity of movement were reduced in intra-CeA PACAP-injected animals tested
Positive_regulation (-) of Gene_expression (injected) of PACAP associated with amygdala
9) Confidence 0.43 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 1.22 Pain Relevance 0.37
Intra-CeA PACAP infusion reduces number of shocks without
Positive_regulation (-) of Gene_expression (infusion) of PACAP associated with shock and amygdala
10) Confidence 0.43 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.50 Pain Relevance 0.28
No intra-CeA PACAP injection effects were found in animals tested with the
Neg (No) Positive_regulation (-) of Gene_expression (injection) of PACAP associated with amygdala
11) Confidence 0.43 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.47 Pain Relevance 0.34

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