INT66061

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 8.67
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AFP) extracellular space (AFP) extracellular region (AFP)
cytoplasm (AFP)
Anatomy Link Frequency
liver 8
brain 2
AFP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 100.00 Very High Very High Very High
pain flank 1 97.76 Very High Very High Very High
Pain 1 95.12 Very High Very High Very High
fibrosis 2 94.80 High High
abdominal pain 6 93.52 High High
headache 1 78.84 Quite High
methotrexate 2 29.64 Quite Low
Disease Link Frequency Relevance Heat
Metastasis 57 100.00 Very High Very High Very High
Stomach Cancer 79 99.98 Very High Very High Very High
Cancer 33 99.92 Very High Very High Very High
Cirrhosis 8 99.86 Very High Very High Very High
Thrombosis 14 99.68 Very High Very High Very High
Lymphadenopathy 1 99.52 Very High Very High Very High
Liver Cancer 2 98.92 Very High Very High Very High
Gynecomastia 1 98.24 Very High Very High Very High
Flank Pain 1 97.76 Very High Very High Very High
Hepatocellular Cancer 12 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, portal thrombus associated with liver cirrhosis might induce an extremely high level of AFP production.
Spec (might) Positive_regulation (induce) of Gene_expression (production) of AFP in liver associated with cirrhosis and thrombosis
1) Confidence 0.70 Published 1996 Journal Surg. Today Section Abstract Doc Link 8897683 Disease Relevance 0.94 Pain Relevance 0.13
Serum levels of alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) were elevated.
Positive_regulation (elevated) of Gene_expression (levels) of AFP associated with antagonist
2) Confidence 0.70 Published 2002 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 12658413 Disease Relevance 0.98 Pain Relevance 0.14
Levels of lactic dehydrogenase, human beta-chorionic gonadotropin, alpha-fetoprotein, DUPAN-2 and carbohydrate antigen 19-9 were elevated.
Positive_regulation (elevated) of Gene_expression (Levels) of alpha-fetoprotein
3) Confidence 0.67 Published 2008 Journal Int. J. Urol. Section Abstract Doc Link 18304228 Disease Relevance 0.77 Pain Relevance 0.10
Serum levels of alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) were elevated.
Positive_regulation (elevated) of Gene_expression (levels) of alpha-fetoprotein associated with antagonist
4) Confidence 0.50 Published 2002 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 12658413 Disease Relevance 0.98 Pain Relevance 0.14
The serum levels of alpha-fetoprotein, human chorionic gonadotropin-beta, and lactate dehydrogenase (LDH) were not elevated.
Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of alpha-fetoprotein
5) Confidence 0.48 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20104012 Disease Relevance 0.86 Pain Relevance 0.10
Thus, portal thrombus associated with liver cirrhosis might induce an extremely high level of AFP production.
Spec (might) Positive_regulation (level) of Gene_expression (production) of AFP in liver associated with cirrhosis and thrombosis
6) Confidence 0.47 Published 1996 Journal Surg. Today Section Abstract Doc Link 8897683 Disease Relevance 0.93 Pain Relevance 0.12
However, multiple new liver metastases appeared and serum AFP levels increased after 5 months.
Positive_regulation (increased) of Gene_expression (levels) of serum AFP in liver associated with metastasis
7) Confidence 0.43 Published 2007 Journal World J Surg Oncol Section Abstract Doc Link PMC1939849 Disease Relevance 1.24 Pain Relevance 0
Initially, the patient's AFP levels dramatically decreased and CT showed regression of metastatic liver tumors; however, multiple new liver metastases appeared and serum AFP levels increased after 5 months.
Positive_regulation (increased) of Gene_expression (levels) of serum AFP in liver associated with liver cancer and metastasis
8) Confidence 0.43 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1939849 Disease Relevance 1.22 Pain Relevance 0
[Gastric cancer producing AFP/HCG which had a rapidly progressive course with metastasis to the brain discovered postoperatively].
Positive_regulation (discovered) of Gene_expression (producing) of AFP in brain associated with metastasis and stomach cancer
9) Confidence 0.43 Published 2007 Journal Nippon Shokakibyo Gakkai Zasshi Section Title Doc Link 17485946 Disease Relevance 0.74 Pain Relevance 0.08

General Comments

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