INT66077

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Context Info
Confidence 0.38
First Reported 1996
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 6.10
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CHPT1) lipid metabolic process (CHPT1)
Anatomy Link Frequency
eyes 1
tear 1
blood 1
neuron 1
amygdala 1
CHPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 162 99.96 Very High Very High Very High
substance P 68 99.92 Very High Very High Very High
Cold hyperalgesia 10 99.46 Very High Very High Very High
Quantitative sensory testing 50 99.20 Very High Very High Very High
lidocaine 12 99.04 Very High Very High Very High
dexamethasone 1 98.32 Very High Very High Very High
aspirin 1 97.42 Very High Very High Very High
Paracetamol 1 93.52 High High
Pain 182 92.48 High High
Thermal hyperalgesia 2 91.28 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 59 99.56 Very High Very High Very High
Hyperalgesia 43 99.46 Very High Very High Very High
Neuropathic Pain 184 99.12 Very High Very High Very High
Reflex Sympathetic Dystrophy 132 98.54 Very High Very High Very High
Hypoxia 9 98.52 Very High Very High Very High
Cv Unclassified Under Development 4 98.36 Very High Very High Very High
Colon Cancer 12 97.32 Very High Very High Very High
Pulmonary Disease 2 96.60 Very High Very High Very High
Pathologic Constriction 2 95.96 Very High Very High Very High
Toxicity 1 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CPT versus anticipation of heat +CPT, i.e., to directly examine the degree to which engagement in the CPT affected amygdala activity during aversive anticipation; 2) anticipation of heat +CPT/RT versus anticipation of heat ?
Spec (examine) Regulation (affected) of CPT in amygdala associated with amygdala
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0 Pain Relevance 0.32
CPT conditions), one outlier regressor to control for physiological and scanner noise, three movement regressors to account for residual motion (in the roll, pitch, and yaw direction), and regressors for baseline and linear trends to account for signal drifts.
Regulation (control) of CPT
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.14 Pain Relevance 0.17
Moreover, the epicardial vasodilation was not significatly affected during CPT or CFR measurements before drinking and after moderate and high doses.
Neg (not) Regulation (affected) of CPT associated with increased venous pressure under development
3) Confidence 0.36 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2427009 Disease Relevance 0.10 Pain Relevance 0.03
Future studies with larger sample sizes are required to examine the effects of thrust manipulation on PPT, HPT, CPT, or PFG.


Spec (examine) Regulation (effects) of CPT
4) Confidence 0.26 Published 2008 Journal J Manipulative Physiol Ther Section Body Doc Link 19028251 Disease Relevance 0 Pain Relevance 0
A 3-way analysis of variance (ANOVA) with time (pre-post) and side (ipsilateral, contralateral to the intervention) as within-subjects variable and intervention (manipulation or MCI) as between-subjects variable was used to evaluate changes in PPT, HPT, CPT, or PFG.
Regulation (changes) of CPT
5) Confidence 0.26 Published 2008 Journal J Manipulative Physiol Ther Section Body Doc Link 19028251 Disease Relevance 0.11 Pain Relevance 0
Transthoracic echocardiography is a widely used non-invasive bedside method for assessing CPT and CFR responses and it correlates with invasive measurements using a Doppler guide wire [31] and myocardial blood flow quantified with PET [19].
Regulation (responses) of CPT in blood
6) Confidence 0.25 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2427009 Disease Relevance 0.98 Pain Relevance 0.08
Caffeine, acetylsalicylic acid, coumarin, cisplatin, ethanol, dexamethasone, 5-fluorouracil, loperamide, and prochlorperazine had no statistically significant effect on CPT-11 hydrolysis.
Neg (no) Regulation (effect) of CPT-11 associated with aspirin and dexamethasone
7) Confidence 0.21 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9321519 Disease Relevance 0 Pain Relevance 0.19
Occasional cases in which S-1/CPT-11 therapy was effective have been recently reported, and a high response rate in advanced colorectal cancer has also been reported1.
Regulation (effective) of CPT-11 associated with colon cancer
8) Confidence 0.15 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1395313 Disease Relevance 0.50 Pain Relevance 0
In acute CRPS I, patients showed warm and cold hyperalgesia, indicated by significant changes in HPT and CPT.
Regulation (changes) of CPT associated with hyperalgesia, cold hyperalgesia and reflex sympathetic dystrophy
9) Confidence 0.11 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2453233 Disease Relevance 1.49 Pain Relevance 0.66
A comparison of clearance in hospitalized patients demonstrated equivalent efficacy of CPT and HFCWO [12,13].
Regulation (efficacy) of CPT
10) Confidence 0.06 Published 2008 Journal J Trauma Manag Outcomes Section Body Doc Link PMC2569011 Disease Relevance 0.52 Pain Relevance 0
Substance P, CGRP, NPY, and VIP tear levels in healthy subjects showed no changes before and after CPT (SP=3.1±0.5 ng/ml versus 3.4±1.5 ng/ml, respectively, p=NSS; CGRP=6.8±3.7 ng/ml versus 7±4 ng/ml; p=NSS; NPY=3.6±1 ng/ml versus 3.6±0.8 ng/ml, p=NSS; VIP=5.4±4.1 ng/ml versus 5.4±2.9 ng/ml, p=NSS).


Regulation (changes) of CPT in tear associated with substance p
11) Confidence 0.04 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.07 Pain Relevance 0.38
No significant changes were observed at baseline and after CPT in SP, CGRP, NPY, and VIP tear levels between eyes challenged with allergen and eyes challenged with diluent.
Regulation (changes) of CPT in eyes associated with substance p
12) Confidence 0.04 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.16 Pain Relevance 0.36
Our data permitted comparison of CDN/CPN and CDT/CPT for only a single neuron (the results were identical), so any difference is purely speculative.
Regulation (permitted) of CPT in neuron
13) Confidence 0.03 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2576218 Disease Relevance 0 Pain Relevance 0
Despite the reduction in phosphatidylcholine biosynthesis, no change in the activity of cytidine diphosphocholine (CDPcholine):diacylglycerol cholinephosphotransferase was detected following lidocaine or hypoxic perfusion.
Neg (no) Regulation (change) of cholinephosphotransferase associated with hypoxia and lidocaine
14) Confidence 0.01 Published 1996 Journal Lipids Section Abstract Doc Link 8898305 Disease Relevance 0.72 Pain Relevance 0.88
CDT, WDT, CPT and HPT were measured in all patients with neuropathy and in 24 healthy controls (Fig. 4).
Regulation (measured) of CPT associated with neuropathic pain
15) Confidence 0.01 Published 2008 Journal Brain Section Body Doc Link PMC2442424 Disease Relevance 1.31 Pain Relevance 0.15

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