INT66099

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Context Info
Confidence 0.25
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.86
Pain Relevance 6.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
spinal 1
monocytes 1
sciatic nerve 1
lymphocytes 1
neurons 1
Sst (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 114 100.00 Very High Very High Very High
electroacupuncture 21 99.92 Very High Very High Very High
neuralgia 3 99.34 Very High Very High Very High
Neuropathic pain 16 98.72 Very High Very High Very High
spinal dorsal horn 6 98.60 Very High Very High Very High
dorsal root ganglion 16 97.90 Very High Very High Very High
Eae 9 97.60 Very High Very High Very High
Sciatic nerve 3 95.96 Very High Very High Very High
Opioid 3 95.20 Very High Very High Very High
Neuropeptide 71 94.92 High High
Disease Link Frequency Relevance Heat
Cancer 26 99.28 Very High Very High Very High
Ganglion Cysts 19 99.16 Very High Very High Very High
Neuropathic Pain 16 98.72 Very High Very High Very High
Injury 9 96.76 Very High Very High Very High
Granuloma 4 93.20 High High
Adenoma 13 92.92 High High
Apoptosis 3 90.64 High High
Weight Loss 1 89.96 High High
Polyuria 1 89.00 High High
Hyperglycemia 1 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The clinical response in terms of GH control and tumor size reduction correlates with the expression of somatostatin receptor subtype 2a (Fougner et al 2008; Taboada et al 2008) Preoperative treatment with lanreotide SR for 1–3 months in 104 acromegalic patients led to tumor size reduction in 66%, with a mean decrease of 152 mm3.
Transcription (expression) of somatostatin associated with cancer and somatostatin
1) Confidence 0.25 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 1.05 Pain Relevance 0.16
Somatostatin-containing interneurons also displayed small nuclei with heterochromatin located in a single central clump, but could be distinguished from the other types of interneurons by their elongated nuclei (axis ratio ?
Transcription (distinguished) of Somatostatin in interneurons associated with somatostatin
2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0 Pain Relevance 0.20
The presence of binding sites for somatostatin and the expression of mRNA for somatostatin receptors (sstr1-5) on lymphocytes and monocytes is established, although the expression of a particular somatostatin receptor subtype on T lymphocytes seems to vary with species and with the origins of the T cells.
Transcription (expression) of somatostatin in monocytes associated with somatostatin
3) Confidence 0.17 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.09 Pain Relevance 0.51
Using immunohistochemistry and RT-PCR, the present study observed the effects of EA on the expression of SOM peptide and preprosomatostatin (ppSOM) mRNA in a rat model of neuropathic pain induced by chronic constriction injury (CCI) to the sciatic nerve.
Transcription (expression) of preprosomatostatin in sciatic nerve associated with eae, injury, neuropathic pain, somatostatin, sciatic nerve and electroacupuncture
4) Confidence 0.07 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15970377 Disease Relevance 0.83 Pain Relevance 1.59
The presence of binding sites for somatostatin and the expression of mRNA for somatostatin receptors (sstr1-5) on lymphocytes and monocytes is established, although the expression of a particular somatostatin receptor subtype on T lymphocytes seems to vary with species and with the origins of the T cells.
Transcription (expression) of somatostatin in lymphocytes associated with somatostatin
5) Confidence 0.06 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.09 Pain Relevance 0.51
Effects of electroacupuncture on expression of somatostatin and preprosomatostatin mRNA in dorsal root ganglions and spinal dorsal horn in neuropathic pain rats.
Transcription (expression) of preprosomatostatin in dorsal root ganglions associated with ganglion cysts, neuralgia, spinal dorsal horn, neuropathic pain, somatostatin and electroacupuncture
6) Confidence 0.05 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15970377 Disease Relevance 0.79 Pain Relevance 1.67
For determination of peptide encoding mRNAs distributed in DRG neurons, in situ hybridization histochemistry utilizing S-end-labeled oligonucleotides complimentary to sequences of preprosomatostatin (PPSOM), preprocalcitonin gene related peptide (PPCGRP), preprotachykinin (PPT), or preproneuropeptide Y (PPNPY) mRNA was performed.
Transcription (sequences) of preprosomatostatin in neurons associated with dorsal root ganglion
7) Confidence 0.04 Published 1996 Journal Peptides Section Abstract Doc Link 8899822 Disease Relevance 1.22 Pain Relevance 0.64
Effects of electroacupuncture on expression of somatostatin and preprosomatostatin mRNA in dorsal root ganglions and spinal dorsal horn in neuropathic pain rats.
Transcription (expression) of preprosomatostatin in spinal associated with ganglion cysts, neuralgia, spinal dorsal horn, neuropathic pain, somatostatin and electroacupuncture
8) Confidence 0.02 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15970377 Disease Relevance 0.79 Pain Relevance 1.67

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