INT661

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Context Info
Confidence 0.78
First Reported 1975
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 100
Total Number 100
Disease Relevance 48.21
Pain Relevance 11.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 20
blood 9
sympathetic 3
ovary 3
endothelium 3
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 197 100.00 Very High Very High Very High
Clonidine 28 99.98 Very High Very High Very High
Catecholamine 21 99.96 Very High Very High Very High
beta blocker 34 99.80 Very High Very High Very High
narcan 6 99.78 Very High Very High Very High
cva 52 99.72 Very High Very High Very High
Neuropeptide 12 99.50 Very High Very High Very High
opioid receptor 5 99.32 Very High Very High Very High
Enkephalin 4 99.08 Very High Very High Very High
medulla 7 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 58 100.00 Very High Very High Very High
Paraganglioma 4 100.00 Very High Very High Very High
Disease 189 99.96 Very High Very High Very High
Syndrome 149 99.92 Very High Very High Very High
Targeted Disruption 56 99.88 Very High Very High Very High
Hyponatremia 36 99.80 Very High Very High Very High
Hypertension 796 99.78 Very High Very High Very High
Pre-eclampsia 264 99.74 Very High Very High Very High
Hemorrhage 22 99.72 Very High Very High Very High
Diuresis 7 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Highly purified recombinant human renin (rh-renin), synthesized by Chinese hamster ovary cells, was labeled with iodine-125 and was given intravenously to pentobarbital-anesthetized common marmosets (Callithrix jacchus) to study the fate of the circulating renin.
Gene_expression (synthesized) of renin in ovary
1) Confidence 0.78 Published 1988 Journal Hypertension Section Abstract Doc Link 3049339 Disease Relevance 0 Pain Relevance 0
Cortisol and aldosterone excess suppresses renin production through negative feedback.
Gene_expression (production) of renin
2) Confidence 0.77 Published 2010 Journal J Gen Intern Med Section Body Doc Link PMC2811596 Disease Relevance 0.39 Pain Relevance 0
Thus, sodium depletion stimulates total renin release, while propranolol and clonidine produce divergent responses of active renin and prorenin, the changes in prorenin depending on the changes induced in blood-pressure.
Gene_expression (produce) of renin in blood associated with clonidine
3) Confidence 0.76 Published 1977 Journal Lancet Section Abstract Doc Link 71600 Disease Relevance 0.14 Pain Relevance 0.19
Highly purified recombinant human renin (rh-renin), synthesized by Chinese hamster ovary cells, was labeled with iodine-125 and was given intravenously to pentobarbital-anesthetized common marmosets (Callithrix jacchus) to study the fate of the circulating renin.
Gene_expression (synthesized) of rh-renin in ovary
4) Confidence 0.68 Published 1988 Journal Hypertension Section Abstract Doc Link 3049339 Disease Relevance 0 Pain Relevance 0
We conclude that in our hypertensive patients with renal artery stenosis, clonidine lowered blood pressure by a reduction in central sympathetic activity independently of renin suppression.
Gene_expression (suppression) of renin in sympathetic associated with renal artery obstruction, pressure volume 2 under development, hypertension and clonidine
5) Confidence 0.66 Published 1988 Journal J Hypertens Suppl Section Abstract Doc Link 3071592 Disease Relevance 0.66 Pain Relevance 0.44
PRA: plasma renin activity
Gene_expression (activity) of renin in plasma
6) Confidence 0.66 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.50 Pain Relevance 0.10
However, the unchanged renin levels were rather unexpected, since an overactivity of sympathetic system has been shown in depressive disorder (for review see [48]).
Gene_expression (unexpected) of renin in sympathetic associated with depressive disorder
7) Confidence 0.66 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.10 Pain Relevance 0
The exercise-induced increases in heart rate; cardiac output; leg blood flow; plasma concentrations of growth hormone, adrenocorticotropin, cortisol, and catecholamines; renin activity; glucose production and disappearance; norepinephrine spillover [2, 190 +/- 341 ng/min (exercise at 11.5% O(2)) vs. 988 +/- 95 ng/min (exercise during normoxia)]; lactate release from and glucose uptake in the leg; and the decreases in plasma insulin and free fatty acids were exaggerated in hypoxia (P < 0.05).
Gene_expression (activity) of renin in plasma associated with hypoxia and catecholamine
8) Confidence 0.65 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10409260 Disease Relevance 0.52 Pain Relevance 0.18
In the group given Doxazocin, there was a significant increase in serum progesterone and ovarian renin angiotensin system soluble and membrane-bound enzymes confirming that alpha adrenergic receptors caused inhibition of progesterone release.
Gene_expression (enzymes) of renin
9) Confidence 0.65 Published 2008 Journal Cases J Section Body Doc Link PMC2481240 Disease Relevance 0.22 Pain Relevance 0.09
(3) What is the relationship among blood volume, blood pressure, cation metabolism, and the ANP-renin-angiotensin system in perioperative patients?
Gene_expression (system) of renin in blood
10) Confidence 0.65 Published 1989 Journal J Cardiothorac Anesth Section Abstract Doc Link 2535291 Disease Relevance 0.17 Pain Relevance 0.07
Multiple neuropeptide immunoreactivities in a renin-producing human paraganglioma.
Gene_expression (producing) of renin associated with neuropeptide, paraganglioma and enkephalin
11) Confidence 0.64 Published 1994 Journal Cancer Section Title Doc Link 7911735 Disease Relevance 0.29 Pain Relevance 0.29
BACKGROUND: A case of a renin-producing paraganglioma of adrenal origin with metastases to the retroperitoneal area, paravaginal area, and the ovary is reported with immunohistochemical findings indicating expression of multiple neuropeptide immunoreactivities.
Gene_expression (producing) of renin in ovary associated with neuropeptide, paraganglioma and metastasis
12) Confidence 0.64 Published 1994 Journal Cancer Section Abstract Doc Link 7911735 Disease Relevance 0.27 Pain Relevance 0.08
We compared the effects of an Angiotensin II receptor antagonist (ARA) on Plasma Renin and blood pressure (BP) following an oral single dose (sd) and once daily md for seven days to healthy volunteers and patients with essential hypertension (diastolic BP 95 mmHg to 114 mmHg; systolic BP 130 mmHg to 200 mmHg).
Gene_expression (effects) of Renin in blood associated with antagonist and hypertension
13) Confidence 0.63 Published 2007 Journal Biomarker Insights Section Abstract Doc Link PMC2717814 Disease Relevance 0.28 Pain Relevance 0.21
In a study in healthy volunteers and diabetic patients, a strong correlation between Renin activity and Renin concentration was demonstrated for both study populations (Valabhji J et al. 2001).
Gene_expression (concentration) of Renin associated with diabetes mellitus
14) Confidence 0.63 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717814 Disease Relevance 0.25 Pain Relevance 0.06
In a study in healthy volunteers and diabetic patients, a strong correlation between Renin activity and Renin concentration was demonstrated for both study populations (Valabhji J et al. 2001).
Gene_expression (activity) of Renin associated with diabetes mellitus
15) Confidence 0.63 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717814 Disease Relevance 0.25 Pain Relevance 0.03
Probably due to the absence of influence of disease, Renin changes in healthy volunteers were even higher than in patients and also showed a better dose-response relationship.
Gene_expression (changes) of Renin associated with disease
16) Confidence 0.63 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717814 Disease Relevance 0.23 Pain Relevance 0.04
The first renin inhibitors were synthesized already more than 30-years ago (Gross et al 1971).
Gene_expression (synthesized) of renin
17) Confidence 0.62 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.11 Pain Relevance 0.11
On the one hand, an intact sympathetic nervous system prevents reduction in blood pressure immediately; on the other hand, sympathetic activation directly stimulates renin production; the result is diminished and elevated sodium retention respectively.
Gene_expression (production) of renin in blood
18) Confidence 0.61 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910895 Disease Relevance 0.38 Pain Relevance 0
Sympathetic activation also directly stimulates renin production, which induces sodium retention.
Gene_expression (production) of renin in Sympathetic
19) Confidence 0.61 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910895 Disease Relevance 0.65 Pain Relevance 0.03
The systemic consequence of vasodilatation is reduction of blood pressure (bottom), leading to renin production and sodium retention.
Gene_expression (production) of renin in blood associated with increased venous pressure under development
20) Confidence 0.61 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910895 Disease Relevance 0.45 Pain Relevance 0

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