INT66118

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Context Info
Confidence 0.46
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 18
Disease Relevance 1.46
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Calr) Golgi apparatus (Calr) endoplasmic reticulum (Calr)
cytoplasm (Calr) cytosol (Calr) protein folding (Calr)
Anatomy Link Frequency
tail 1
Calr (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 99.98 Very High Very High Very High
Inflammation 35 73.28 Quite High
ketamine 15 53.84 Quite High
anesthesia 17 52.08 Quite High
Calcium channel 30 39.16 Quite Low
Glutamate 15 5.20 Low Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 15 100.00 Very High Very High Very High
Wound Healing 15 97.56 Very High Very High Very High
Stress 43 97.52 Very High Very High Very High
Cancer 16 94.64 High High
Hepatotoxicity 2 92.72 High High
American Trypanosomiasis 60 84.96 Quite High
Togavirus Infection 15 79.04 Quite High
INFLAMMATION 29 73.28 Quite High
Myositis 42 69.44 Quite High
Coronary Heart Disease 15 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The covalent binding of [14C]acetaminophen to mouse hepatic microsomal proteins: the specific binding to calreticulin and the two forms of the thiol:protein disulfide oxidoreductases.
calreticulin Binding (binding) of associated with paracetamol
1) Confidence 0.46 Published 1996 Journal Chem. Res. Toxicol. Section Title Doc Link 8902274 Disease Relevance 0.05 Pain Relevance 0.54
In this state CRT would be recognized by the ERAD machinery, which would then retrotranslocate the protein to the cytosol.
CRT Binding (recognized) of
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
It participates in glycoprotein binding and interacts with ERp57, which collaborates in the folding maturation of glycoproteins bound to CRT [6].
CRT Binding (bound) of
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.14 Pain Relevance 0
Sequencing of the 14C-labeled tryptic peptides indicated that the acetaminophen bound to lysine 103 of Q2, lysines 202, 209 or 210 and 354 of Q5 and lysines 233 or 239 of calreticulin.
calreticulin Binding (bound) of associated with paracetamol
4) Confidence 0.31 Published 1996 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8902274 Disease Relevance 0.09 Pain Relevance 0.58
Moreover, the calcium-regulated interaction between PDI and CRT depends on CRT-C.
CRT Binding (interaction) of
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Taken together, these results showed that the retrotranslocation process and its response to ER calcium levels exclusively depend on TcCRT-C.
TcCRT Binding (depend) of
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
We are currently studying the association between PDI and CRT in vivo.
CRT Binding (association) of
7) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Cytosolic TcCRT accounted for about 2% of the total protein (Figure 1B).
TcCRT Binding (accounted) of
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Accordingly, CRT has been associated with several biological functions, its roles as a lectin/chaperone in the folding of glycoproteins and as calcium buffer within the ER being the most prominent.
CRT Binding (associated) of
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
On the other hand, cytosolic CRT regulates cell adhesion through its interaction with the cytosolic tail of integrin alpha subunit [17] and also mediates the nuclear export of some steroid hormone receptors [7], [18], [19].
CRT Binding (interaction) of in tail associated with adhesions
10) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.43 Pain Relevance 0
Clearly, TcCRT migration depended on its cellular localization, as the protein present in the ER showed a migration slower than that present in the cytosol (Figure 8).
TcCRT Binding (migration) of
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Cytosolic TcCRT is degraded by the proteasome
TcCRT Binding (Cytosolic) of
12) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
The presence of biotinylated TcCRT was analized by immunoprecipitation of TcCRT followed by Western blot using Streptavidin-HRP.
TcCRT Binding (immunoprecipitation) of
13) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
In this state, CRT would be recognized by the ERAD machinery, which would retrotranslocate the protein to the cytosol.
CRT Binding (recognized) of
14) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.06 Pain Relevance 0.08
There are currently two models to explain the presence of CRT in the cytosol.
CRT Binding (presence) of
15) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.35 Pain Relevance 0
Secondly, CRT can bind high amounts of calcium (?
CRT Binding (bind) of
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.08 Pain Relevance 0
Firstly, due to its capacity to bind monoglucosylated high mannose glycans, CRT is a central component of the glycoprotein folding quality control system.
CRT Binding (bind) of
17) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.07 Pain Relevance 0
Regenerating myofibers reacted strongly for Grp94 (Figure 4e), whereas they showed variable immunoreactivity for CHOP (Figure 4f, arrows) and calreticulin (data not shown).
calreticulin Binding (immunoreactivity) of
18) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.19 Pain Relevance 0.06

General Comments

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