INT66188

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Context Info
Confidence 0.01
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.51

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endosome (ADRB2) extracellular region (CDSN) cell adhesion (CDSN)
plasma membrane (ADRB2) nucleus (ADRB2) lysosome (ADRB2)
ADRB2 (Homo sapiens)
CDSN (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 2 99.62 Very High Very High Very High
antagonist 10 81.92 Quite High
Potency 2 81.04 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the alpha 1-adrenoceptor-binding studies on the human prostate with [3H]doxazosin and 2-{[beta-(3-[125I],4-hydroxyphenyl)ethyl]aminomethyl}-l-tetralone ([125I]HEAT), no significant differences were observed between racemic doxazosin, R-doxazosin and S-doxazosin (mean -log Ki (pKi) values were 8.60-8.63, 8.47-8.55 and 8.61-8.65, respectively), whereas the alpha 2-adrenoceptor-binding studies with [3H]rauwolscine and [3H]clonidine revealed that the alpha 2-adrenoceptor-binding affinity of S-doxazosin (pKi = 5.91-5.94) was slightly (3- or 4-fold), but significantly lower than that of R-doxazosin (pKi = 6.47-6.54).
alpha 2-adrenoceptor-binding Binding (affinity) of S-doxazosin associated with clonidine
1) Confidence 0.01 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8905340 Disease Relevance 0 Pain Relevance 0.26
In the alpha 1-adrenoceptor-binding studies on the human prostate with [3H]doxazosin and 2-{[beta-(3-[125I],4-hydroxyphenyl)ethyl]aminomethyl}-l-tetralone ([125I]HEAT), no significant differences were observed between racemic doxazosin, R-doxazosin and S-doxazosin (mean -log Ki (pKi) values were 8.60-8.63, 8.47-8.55 and 8.61-8.65, respectively), whereas the alpha 2-adrenoceptor-binding studies with [3H]rauwolscine and [3H]clonidine revealed that the alpha 2-adrenoceptor-binding affinity of S-doxazosin (pKi = 5.91-5.94) was slightly (3- or 4-fold), but significantly lower than that of R-doxazosin (pKi = 6.47-6.54).
alpha 2-adrenoceptor-binding Binding (affinity) of S-doxazosin associated with clonidine
2) Confidence 0.01 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8905340 Disease Relevance 0 Pain Relevance 0.26

General Comments

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