INT66192

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Context Info
Confidence 0.01
First Reported 1996
Last Reported 1997
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.65
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PPAP2A) plasma membrane (PPAP2A) lipid metabolic process (PPAP2A)
Anatomy Link Frequency
blood 10
PPAP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 32 99.84 Very High Very High Very High
Catecholamine 20 99.20 Very High Very High Very High
agonist 4 98.80 Very High Very High Very High
addiction 1 75.00 Quite High
noradrenaline 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypotension 5 90.48 High High
Hypogonadotropic Hypogonadism 15 85.04 High High
Bordatella Infection 2 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In isolated cell membranes, activation of alpha2A- and alpha2C-adrenoceptors did not affect basal enzyme activity, but activation of alpha2B-adrenoceptors stimulated adenylyl cyclase activity.
Neg (not) Regulation (affect) of Positive_regulation (activation) of alpha2A
1) Confidence 0.01 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9371546 Disease Relevance 0.16 Pain Relevance 0.09
Our present findings demonstrate that, differently from in animal, in man testosterone has no role in modulating the effects of alpha-2 adrenergic activation by clonidine on blood pressure, catecholamine and GH release.
Regulation (effects) of Positive_regulation (activation) of alpha-2 in blood associated with catecholamine and clonidine
2) Confidence 0.00 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0 Pain Relevance 0.26
Thus, these data point to main role of the gonadal steroid testosterone in modulating the effects of alpha-2 adrenergic activation on blood pressure, catecholamine and GH release in animal.
Regulation (modulating) of Positive_regulation (activation) of alpha-2 in blood associated with catecholamine
3) Confidence 0.00 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0.25 Pain Relevance 0.46
Our present findings demonstrate that, differently from in animal, in man testosterone has no role in modulating the effects of alpha-2 adrenergic activation by clonidine on blood pressure, catecholamine and GH release.
Neg (no) Regulation (role) of Positive_regulation (activation) of alpha-2 in blood associated with catecholamine and clonidine
4) Confidence 0.00 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0 Pain Relevance 0.26
Thus, these data point to main role of the gonadal steroid testosterone in modulating the effects of alpha-2 adrenergic activation on blood pressure, catecholamine and GH release in animal.
Regulation (effects) of Positive_regulation (activation) of alpha-2 in blood associated with catecholamine
5) Confidence 0.00 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0.25 Pain Relevance 0.46
Our present findings demonstrate that, differently from in animal, in man testosterone has no role in modulating the effects of alpha-2 adrenergic activation by clonidine on blood pressure, catecholamine and GH release.
Regulation (modulating) of Positive_regulation (activation) of alpha-2 in blood associated with catecholamine and clonidine
6) Confidence 0.00 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0 Pain Relevance 0.26

General Comments

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