INT66193

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.39
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Btd) extracellular region (Btd) nucleolus (Btd)
Anatomy Link Frequency
plasma 1
Btd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anticonvulsant 7 98.60 Very High Very High Very High
Lamotrigine 20 92.88 High High
corticosteroid 18 85.92 High High
positron emission tomography 2 76.32 Quite High
hyperexcitability 2 75.00 Quite High
Paracetamol 3 50.00 Quite Low
tetrodotoxin 1 40.32 Quite Low
gABA 20 5.00 Very Low Very Low Very Low
sodium channel 10 5.00 Very Low Very Low Very Low
antiepileptic Drug 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biotin Disorder 7 100.00 Very High Very High Very High
Phenylketonuria 4 99.92 Very High Very High Very High
Infantile Spasms 380 99.58 Very High Very High Very High
Convulsion 52 98.24 Very High Very High Very High
Epilepsy 23 95.12 Very High Very High Very High
Congenital Anomalies 9 94.68 High High
Tuberous Sclerosis 16 87.72 High High
Muscular Spasm 56 80.40 Quite High
Malformations Of Cortical Development 4 70.72 Quite High
Encephalopathy 4 52.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, 24 and 40 h after the toxic dose of paracetamol, biotinidase activity was decreased in the liver and increased in the plasma as compared with the control, when plasma ALT was increased.
Negative_regulation (decreased) of biotinidase in plasma
1) Confidence 0.59 Published 2004 Journal Clin. Chim. Acta Section Body Doc Link 15469856 Disease Relevance 0 Pain Relevance 0
Absence of biotinidase activity can also lead to biotin deficiency, and is characterized by developmental delay as well as neurological and dermatological abnormalities.
Negative_regulation (Absence) of biotinidase associated with biotin disorder and congenital anomalies
2) Confidence 0.43 Published 1996 Journal Neuroreport Section Abstract Doc Link 8905656 Disease Relevance 0.55 Pain Relevance 0.12
Rarely, infantile spasms in association with biotinidase deficiency, phenylketonuria, and pyridoxine-dependent seizures are successfully treated with biotin, a low phenylalanine diet, and pyridoxine, respectively.
Negative_regulation (deficiency) of biotinidase associated with biotin disorder, infantile spasms, convulsion and phenylketonuria
3) Confidence 0.02 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2695218 Disease Relevance 1.11 Pain Relevance 0.16
Rarely, infantile spasms occur in association with biotinidase deficiency, which can be treated with biotin successfully.110 Children with infantile spasms associated with phenylketonuria have been reported and were treated successfully with low phenylalanine diet and valproic acid or nitrazepam.111

Surgical treatment

Negative_regulation (deficiency) of biotinidase associated with biotin disorder, infantile spasms and phenylketonuria
4) Confidence 0.02 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695218 Disease Relevance 1.74 Pain Relevance 0.04

General Comments

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