INT66198

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 10.33
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
neural 8
retina 4
optic nerve 4
spinal 2
photoreceptor cell 2
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 5 100.00 Very High Very High Very High
Neuropeptide 3 100.00 Very High Very High Very High
Cancer pain 4 99.48 Very High Very High Very High
tolerance 7 98.32 Very High Very High Very High
Hippocampus 6 98.16 Very High Very High Very High
Neuropathic pain 3 98.16 Very High Very High Very High
anesthesia 16 96.64 Very High Very High Very High
cytokine 45 95.96 Very High Very High Very High
agonist 4 92.32 High High
Cannabinoid 4 92.00 High High
Disease Link Frequency Relevance Heat
Pain 4 100.00 Very High Very High Very High
Bone Cancer 4 99.68 Very High Very High Very High
Injury 213 99.48 Very High Very High Very High
Brain Injury 59 98.98 Very High Very High Very High
Infection 226 98.84 Very High Very High Very High
Cytomegalovirus Infection 228 98.64 Very High Very High Very High
Neuropathic Pain 4 98.16 Very High Very High Very High
Creutzfeldt Jakob Disease 1 98.12 Very High Very High Very High
Gliosis 10 97.80 Very High Very High Very High
Death 50 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that 0.5 mg/kg/day for 18 days reduced pain related behavior and expression of spinal glial fibrillary acidic protein in the bone cancer pain model but not in the neuropathic pain model.
Negative_regulation (reduced) of Gene_expression (expression) of glial fibrillary acidic protein in spinal associated with pain, cancer pain, neuropathic pain and bone cancer
1) Confidence 0.59 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18611408 Disease Relevance 1.17 Pain Relevance 1.46
GFAP immunohistochemistry revealed that GFAP expression was attenuated in the IL-1RI-null mice compared to their WT counterparts following a neocortical stab wound (Fig 1).
Negative_regulation (attenuated) of Gene_expression (expression) of GFAP associated with stab wounds
2) Confidence 0.49 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.27 Pain Relevance 0.10
Thus, these data show that the cellular expression of GFAP is delayed in the IL-1R1 null mice, but that a compensatory mechanism, such as the delayed production of other cytokines, eventually stimulates GFAP expression to the same level as induced in the wild-type animals [45].


Negative_regulation (delayed) of Gene_expression (expression) of GFAP associated with cytokine
3) Confidence 0.49 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.74 Pain Relevance 0.08
Although we observed decreased GFAP expression at this time point, our data indicate that there is reduced GFAP per cell rather than fewer astrocytes.
Negative_regulation (decreased) of Gene_expression (expression) of GFAP in astrocytes
4) Confidence 0.49 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.56 Pain Relevance 0.28
Here we examined, using in situ hybridization histochemistry, the expression of neuropeptide Y (NPY), an inducible and abundant neuropeptide in mammalian brain with known neuroregulatory functions, and glial fibrillary acidic protein (GFAP), a marker for astroglial activation, in the hippocampus at different time points following intracerebral prion inoculation in male CD-1 mice.
Spec (examined) Negative_regulation (using) of Gene_expression (expression) of GFAP in brain associated with neuropeptide and hippocampus
5) Confidence 0.41 Published 1996 Journal Neuroreport Section Abstract Doc Link 8905686 Disease Relevance 0.33 Pain Relevance 0.35
This also correlated with neuroretinal trauma evidenced by a sustained loss in ERG function, increased GFAP levels indicative of active Muller as well as astrocyte cell gliosis, and significant photoreceptor cell degeneration.
Negative_regulation (loss) of Gene_expression (levels) of GFAP in photoreceptor cell associated with injury and gliosis
6) Confidence 0.40 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 1.10 Pain Relevance 0.15
As demonstrated by western blot and subsequent densitometry, GFAP protein expression in retina and optic nerve of PEDF transfected DBA/2J mice was significantly reduced compared to that of GFP transfected mice.


Negative_regulation (reduced) of Gene_expression (expression) of GFAP protein in retina
7) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.38 Pain Relevance 0.07
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Negative_regulation (reduces) of Gene_expression (expression) of GFAP in optic nerve
8) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.23 Pain Relevance 0.21
Cerebral injury assessed by pathological changes and astrogliosis detected by the expression of GFAP
Negative_regulation (detected) of Gene_expression (expression) of GFAP associated with brain injury
9) Confidence 0.36 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.10 Pain Relevance 0
HCMV infection of neural progenitor cells in the undifferentiated stage down-regulated GFAP expression while it remained unaltered following infection after differentiation [46].
Negative_regulation (down) of Gene_expression (expression) of GFAP in neural associated with cytomegalovirus infection and infection
10) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.79 Pain Relevance 0.10
HCMV infection of neural progenitor cells in the undifferentiated stage down-regulated GFAP expression while it remained unaltered following infection after differentiation [46].
Negative_regulation (regulated) of Gene_expression (expression) of GFAP in neural associated with cytomegalovirus infection and infection
11) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.79 Pain Relevance 0.10
HCMV infection of neural progenitor cells in the undifferentiated stage down-regulated GFAP expression while it remained unaltered following infection after differentiation [46].
Negative_regulation (-) of Gene_expression (expression) of GFAP in neural associated with cytomegalovirus infection and infection
12) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.79 Pain Relevance 0.10
Mean fluorescence intensity of DCX and GFAP expression were also measured between the groups.
Negative_regulation (intensity) of Gene_expression (expression) of GFAP
13) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.48 Pain Relevance 0.09
mice lacked an increase in GFAP expression with VP2121–130 peptide treatment (Figure 3E–H).
Negative_regulation (lacked) of Gene_expression (expression) of GFAP
14) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0 Pain Relevance 0.04
Like LC1 cells, NS-5 cells uniformly express nestin, RC2, and other neural precursor markers (Figure 2C), and lack detectable GFAP expression (Part p in Figure 2C).
Negative_regulation (lack) of Gene_expression (expression) of GFAP in neural
15) Confidence 0.20 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Negative_regulation (reduces) of in retina Gene_expression (expression) of GFAP in optic nerve
16) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.23 Pain Relevance 0.21
As demonstrated by western blot and subsequent densitometry, GFAP protein expression in retina and optic nerve of PEDF transfected DBA/2J mice was significantly reduced compared to that of GFP transfected mice.


Negative_regulation (reduced) of in optic nerve Gene_expression (expression) of GFAP protein in retina
17) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.38 Pain Relevance 0.07

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