INT66200

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 14
Speculated 4
Reported most in Body
Documents 215
Total Number 221
Disease Relevance 88.04
Pain Relevance 28.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 29
brain 17
retina 15
optic nerve 12
glial cells 10
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1896 100.00 Very High Very High Very High
Neuropathic pain 202 100.00 Very High Very High Very High
Neuropeptide 10 100.00 Very High Very High Very High
Spinal cord 703 99.86 Very High Very High Very High
Kappa opioid receptor 320 99.82 Very High Very High Very High
Pain 131 99.56 Very High Very High Very High
cytokine 847 99.52 Very High Very High Very High
Cancer pain 4 99.48 Very High Very High Very High
cocaine 34 99.32 Very High Very High Very High
Periaqueductal grey 3 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2216 100.00 Very High Very High Very High
Alzheimer's Dementia 398 100.00 Very High Very High Very High
Cancer 287 100.00 Very High Very High Very High
Neuropathic Pain 285 100.00 Very High Very High Very High
Necrosis 177 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 85 100.00 Very High Very High Very High
Stab Wounds 110 99.96 Very High Very High Very High
Targeted Disruption 1462 99.88 Very High Very High Very High
Glaucoma 1200 99.84 Very High Very High Very High
Injury 1442 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrate that in mouse dentate gyrus, cocaine exposure differently affects the expression of GFAP and induces strong changes in astrocytes proliferation rate and cell morphology.
Gene_expression (expression) of GFAP in astrocytes associated with cocaine
1) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882367 Disease Relevance 0 Pain Relevance 0.30
The results show that, compared to control animals, GFAP expression is two-fold enhanced after a single cocaine injection, still significantly higher after seven consecutive daily administrations, but not statistically different after prolonged (14 days) drug treatment.
Gene_expression (expression) of GFAP associated with cocaine
2) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882367 Disease Relevance 0 Pain Relevance 0.44
Quantitative changes in the expression of glial fibrillary acidic protein (GFAP), a cytoskeletal intermediate filament protein exclusively expressed in astrocytes (Bignami et al, 1972), have been observed after administration of alcohol (Framke, 1995), morphine (Beitner-Johnson et al., 1993), amphetamine and its derivates (Aguirre et al., 1999), cannabinoids (Suarez et al., 2000), nicotine (Janson and Moller, 1993), caffeine (Marret et al., 1993) and prenatal exposure to cocaine (Clarke et al., 1996; Nassogne et al., 1998).
Gene_expression (expression) of GFAP in astrocytes associated with nicotine, cannabinoid, cocaine, morphine and alcohol
3) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882367 Disease Relevance 0 Pain Relevance 0.33
Quantitative changes in the expression of glial fibrillary acidic protein (GFAP), a cytoskeletal intermediate filament protein exclusively expressed in astrocytes (Bignami et al, 1972), have been observed after administration of alcohol (Framke, 1995), morphine (Beitner-Johnson et al., 1993), amphetamine and its derivates (Aguirre et al., 1999), cannabinoids (Suarez et al., 2000), nicotine (Janson and Moller, 1993), caffeine (Marret et al., 1993) and prenatal exposure to cocaine (Clarke et al., 1996; Nassogne et al., 1998).
Gene_expression (expressed) of GFAP in astrocytes associated with nicotine, cannabinoid, cocaine, morphine and alcohol
4) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882367 Disease Relevance 0 Pain Relevance 0.37
We found that 0.5 mg/kg/day for 18 days reduced pain related behavior and expression of spinal glial fibrillary acidic protein in the bone cancer pain model but not in the neuropathic pain model.
Gene_expression (expression) of glial fibrillary acidic protein in spinal associated with pain, cancer pain, neuropathic pain and bone cancer
5) Confidence 0.78 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18611408 Disease Relevance 1.16 Pain Relevance 1.45
The RT-PCR results indicated an increase in C1q mRNA that was more pronounced than the increased expression of GFAP mRNA ipsilateral to the injury in the dorsal spinal cord.
Gene_expression (expression) of GFAP mRNA in spinal cord associated with injury and spinal cord
6) Confidence 0.78 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19766105 Disease Relevance 0.62 Pain Relevance 0.69
Moreover, SNI animals displayed increased interleukin-1beta (IL-1beta) gene expression within the frontal cortex and concurrent increases in the expression of glial fibrillary acidic protein (GFAP) within the periaqueductal grey (PAG).
Gene_expression (expression) of glial fibrillary acidic protein in frontal cortex associated with nervous system injury, periaqueductal grey and urological neuroanatomy
7) Confidence 0.75 Published 2010 Journal Mol. Psychiatry Section Abstract Doc Link 19773812 Disease Relevance 2.34 Pain Relevance 0.61
Here we examined, using in situ hybridization histochemistry, the expression of neuropeptide Y (NPY), an inducible and abundant neuropeptide in mammalian brain with known neuroregulatory functions, and glial fibrillary acidic protein (GFAP), a marker for astroglial activation, in the hippocampus at different time points following intracerebral prion inoculation in male CD-1 mice.
Gene_expression (expression) of GFAP in brain associated with neuropeptide and hippocampus
8) Confidence 0.75 Published 1996 Journal Neuroreport Section Abstract Doc Link 8905686 Disease Relevance 0.32 Pain Relevance 0.35
METHODS: 2.2kb hGFAP-LacZ reporter expressions were examined in four immortalised PSC lines and two non-PSCs, meanwhile, GFAP-LacZ transgenic mice were used to detect LacZ reporter in pancreas tissue.
Gene_expression (expressions) of GFAP in pancreas
9) Confidence 0.75 Published 2009 Journal Dig Liver Dis Section Body Doc Link 18602878 Disease Relevance 0.09 Pain Relevance 0
Previous studies also indicated that GFAP is expressed in neuronal precursor cells during development [24,25].
Gene_expression (expressed) of GFAP in neuronal
10) Confidence 0.74 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.46 Pain Relevance 0.09
Reactive gliosis is another indicator of neuroretinal injury, identified by the upregulation of glial fibrillary acidic protein (GFAP) expression by Muller as well as astrocyte cells.
Gene_expression (expression) of GFAP in astrocyte associated with injury and gliosis
11) Confidence 0.74 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.63 Pain Relevance 0.05
Reactive gliosis is another indicator of neuroretinal injury, identified by the upregulation of glial fibrillary acidic protein (GFAP) expression by Muller as well as astrocyte cells.
Gene_expression (expression) of glial fibrillary acidic protein in astrocyte associated with injury and gliosis
12) Confidence 0.74 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.74 Pain Relevance 0.06
To determine if mice undergo reactive gliosis following intracameral inoculation, we measured retinal levels of GFAP expression by western blot analysis.
Gene_expression (expression) of GFAP associated with gliosis
13) Confidence 0.74 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.50 Pain Relevance 0.03
However, intracamerally inoculated hosts did not demonstrate a significant increase of GFAP expression on day 8 over the negative control.
Gene_expression (expression) of GFAP
14) Confidence 0.74 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.37 Pain Relevance 0
Positive control mice resulted in a twofold increase in GFAP expression on day 8 over the negative control (Figure 5).
Gene_expression (expression) of GFAP
15) Confidence 0.74 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.40 Pain Relevance 0
Since damage to neuronal cells within the SC was not detected during the period of increased GFAP expression, reactive astrocytes may provide crucial support for neurons during this period through such functions as the production of trophic factors and the elimination of toxins [36,37].
Gene_expression (expression) of GFAP in astrocytes
16) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.20 Pain Relevance 0.03
We investigated the time-dependent alterations of activated astrocytes in the superficial layer of the SC by immunohistochemical analysis (Figure 3) At 3, 7, 30, and 90 days and 3, 7, and 30 days after NMDA injection, GFAP expression was observed in the contralateral and ipsilateral SC, respectively (Figure 3A).
Gene_expression (expression) of GFAP in astrocytes
17) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0 Pain Relevance 0
In addition, significant increases in GFAP expression were observed in the ipsilateral SC at 7 days.
Gene_expression (expression) of GFAP
18) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.25 Pain Relevance 0
In the present study, we observed significant increases in BDNF-positive cells in the contralateral SC at 30 and 90 days after NMDA injection, and at least a partial overlap with the cells showing increased expression of GFAP.
Gene_expression (expression) of GFAP
19) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.06 Pain Relevance 0.04
Müller cells do not normally express GFAP, but they can be induced to increase their expression in response to injury [52,53].
Neg (not) Gene_expression (express) of GFAP associated with injury
20) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.10 Pain Relevance 0.18

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