INT66205

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.74
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, TNF, NFKB1) intracellular (TNF, TNF) extracellular matrix organization (TNF, TNF)
extracellular space (TNF, TNF) extracellular region (TNF, TNF) plasma membrane (TNF, TNF)
Anatomy Link Frequency
endothelial cells 2
TNF (Homo sapiens)
TNF (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 10 99.14 Very High Very High Very High
Inflammation 8 96.72 Very High Very High Very High
cINOD 6 95.68 Very High Very High Very High
cytokine 1 51.60 Quite High
Disease Link Frequency Relevance Heat
Necrosis 3 99.82 Very High Very High Very High
Cancer 3 99.64 Very High Very High Very High
Skin Cancer 14 97.68 Very High Very High Very High
INFLAMMATION 11 96.72 Very High Very High Very High
Metastasis 2 91.12 High High
Adhesions 5 86.48 High High
Injury 4 85.68 High High
Stress 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we examined the effect of capsaicin and its analogue, resiniferatoxin, on the activation of NF-kappa B induced by different agents including TNF.
TNF Spec (examined) Positive_regulation (induced) of TNF Spec (examined) Positive_regulation (activation) of NF-kappa B associated with qutenza
1) Confidence 0.41 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.08 Pain Relevance 0.61
In conclusion, sodium salicylate effectively inhibited TNF-alpha-induced upregulation of NF-kappaB, ICAM-1 expression, in-vitro migration and invasion in human melanoma cells, indicating that non-steroidal anti-inflammatory drugs may be a useful therapeutic approach to oppose inflammation-induced melanoma invasion and metastasis in vivo.
TNF-alpha Positive_regulation (induced) of TNF-alpha Positive_regulation (upregulation) of NF-kappaB associated with inflammation, cinod, skin cancer and metastasis
2) Confidence 0.36 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.90 Pain Relevance 0.14
Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells.
TNF-alpha Positive_regulation (induced) of TNF-alpha Positive_regulation (activation) of NF-kappaB associated with skin cancer
3) Confidence 0.36 Published 2006 Journal Melanoma Res. Section Title Doc Link 16432451 Disease Relevance 0.74 Pain Relevance 0.04
High concentrations of NAC and mito-Q instead caused glutathionylation of IKKalpha, thereby inhibiting its activity that in turn enhanced the downstream NF-kappaB activation and ICAM-1 expression by TNF-alpha.
TNF-alpha Positive_regulation (enhanced) of TNF-alpha Positive_regulation (activation) of NF-kappaB
4) Confidence 0.17 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.58 Pain Relevance 0.21
We have demonstrated that two structurally distinct yet highly selective proteasome inhibitors (MG341, lactacystin) inhibit tumor necrosis factor (TNF)-induced NFKB activation as well as ECAM expression in human endothelial cells in vitro.
TNF Positive_regulation (induced) of TNF Positive_regulation (activation) of NFKB in endothelial cells associated with necrosis and cancer
5) Confidence 0.04 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872503 Disease Relevance 0.44 Pain Relevance 0.23

General Comments

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