INT66206

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Context Info
Confidence 0.53
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.71
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, NFKB1) nucleoplasm (NFKB1) mitochondrion (NFKB1)
intracellular (TNF) extracellular matrix organization (TNF) cytoplasm (NFKB1)
TNF (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 10 99.98 Very High Very High Very High
cINOD 2 95.68 Very High Very High Very High
Inflammation 5 92.84 High High
Disease Link Frequency Relevance Heat
Skin Cancer 14 97.68 Very High Very High Very High
Cancer 2 95.84 Very High Very High Very High
Necrosis 2 95.56 Very High Very High Very High
INFLAMMATION 7 95.48 Very High Very High Very High
Metastasis 2 91.12 High High
Adhesions 2 81.04 Quite High
Injury 2 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pretreatment of human myeloid ML-1a cells with capsaicin blocked TNF-mediated activation of NF-kappa B in a dose- and time-dependent manner.
Negative_regulation (blocked) of TNF Positive_regulation (activation) of NF-kappa B associated with qutenza
1) Confidence 0.53 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.08 Pain Relevance 0.63
Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells.
Negative_regulation (inhibits) of TNF-alpha Positive_regulation (activation) of NF-kappaB associated with skin cancer
2) Confidence 0.33 Published 2006 Journal Melanoma Res. Section Title Doc Link 16432451 Disease Relevance 0.74 Pain Relevance 0.04
In conclusion, sodium salicylate effectively inhibited TNF-alpha-induced upregulation of NF-kappaB, ICAM-1 expression, in-vitro migration and invasion in human melanoma cells, indicating that non-steroidal anti-inflammatory drugs may be a useful therapeutic approach to oppose inflammation-induced melanoma invasion and metastasis in vivo.
Negative_regulation (inhibited) of TNF-alpha Positive_regulation (upregulation) of NF-kappaB associated with inflammation, cinod, skin cancer and metastasis
3) Confidence 0.33 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.90 Pain Relevance 0.14

General Comments

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