INT66208

Context Info Confidence 0.68 First Reported 1996 Last Reported 2010 Negated 4 Speculated 1 Reported most in Abstract Documents 45 Total Number 46 Disease Relevance 20.17 Pain Relevance 22.62

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1) cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)

Anatomy Link Frequency neurons 4 skin 4 TMJ 2 neuronal 2 endothelial cells 2 NFKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 64 100.00 Morphine 46 100.00 cytokine 38 100.00 agonist 8 99.86 qutenza 67 99.84 alcohol 19 99.82 nMDA receptor 4 99.78 opioid receptor 29 99.70 substance P 52 99.38 antagonist 21 99.38

Disease Link Frequency Relevance Heat INFLAMMATION 87 100.00 Apoptosis 32 99.96 Skin Cancer 24 99.84 Necrosis 15 99.74 Cancer 48 99.56 Injury 4 98.80 Ovarian Cancer 3 98.44 Leukemia 3 98.16 Osteogenic Sarcomas 2 97.44 Hypoxia 6 97.32

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A non-peptide substance P antagonist (CP-96,345) inhibits morphine-induced NF-kappa B promoter activation in human NT2-N neurons.

Positive_regulation (induced) of Positive_regulation (activation) of NF-kappa B promoter in neurons associated with antagonist, morphine and substance p

1) Confidence 0.68 Published 2004 Journal J. Neurosci. Res. Section Title Doc Link 14743438 Disease Relevance 0.10 Pain Relevance 1.50

Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.

Positive_regulation (essential) of Positive_regulation (activation) of NF-kappa B associated with qutenza

2) Confidence 0.65 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0 Pain Relevance 0.71

These results demonstrate that constitutive and induced NF-kappaB activation regulates IL-8 expression in melanoma cells.

Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB associated with skin cancer

3) Confidence 0.64 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.68 Pain Relevance 0.40

The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells.

Positive_regulation (mediated) of Positive_regulation (activation) of NF-kappaB associated with osteogenic sarcomas and apoptosis

4) Confidence 0.61 Published 2002 Journal Int. J. Oncol. Section Title Doc Link 12012007 Disease Relevance 0.77 Pain Relevance 0.19

Anti-CD44 antibody reversed the inhibitory effects of HA on the LPS-mediated increase in PGE(2) production, COX-2 induction, and activation of NF-kappaB.

Positive_regulation (increase) of Positive_regulation (activation) of NF-kappaB

5) Confidence 0.56 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.25 Pain Relevance 0.27

A lack of NF-kappaB activation was not due to a lack of functional cell/protein because NF-kappaB was appropriately activated by lipopolysaccharide ex vivo in all patients.

Neg (not) Positive_regulation (activated) of Positive_regulation (activation) of NF-kappaB

6) Confidence 0.50 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0.12 Pain Relevance 0

NF-kappaB activation was not a nonspecific response of all transcription factors because neither Sp1 or Oct1 was activated in patients with activated NF-kappaB.

Neg (neither) Positive_regulation (activated) of Positive_regulation (activated) of NF-kappaB

7) Confidence 0.50 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0 Pain Relevance 0

High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.

Positive_regulation (lipopolysaccharide-induced) of Positive_regulation (activation) of NF-kappa B

8) Confidence 0.49 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.19 Pain Relevance 0.24

Investigation of the mechanism responsible for morphine-induced activation of NF-kappaB promoter in NT2-N neurons demonstrated that morphine activates the SP promoter and induces SP expression in these cells.

Positive_regulation (morphine-induced) of Positive_regulation (activation) of NF-kappaB promoter in neurons associated with substance p and morphine

9) Confidence 0.49 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 14743438 Disease Relevance 0.07 Pain Relevance 1.78

DAMGO, a selective mu-opioid receptor agonist, also induced NF-kappaB promoter activation.

Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB promoter associated with agonist and opioid receptor

10) Confidence 0.49 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 14743438 Disease Relevance 0.08 Pain Relevance 1.54

We investigated whether the neurokinin-1 receptor (SP receptor) pathway is biologically involved in morphine-mediated modulation of NF-kappaB promoter activation in a human neuronal cell line (NT2-N) that expresses both the mu-opioid receptor (MOR) and the SP receptor.

Spec (whether) Positive_regulation (modulation) of Spec (whether) Positive_regulation (activation) of NF-kappaB promoter in neuronal associated with opioid receptor, morphine and substance p

11) Confidence 0.49 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 14743438 Disease Relevance 0.09 Pain Relevance 1.29

Histochemical and Western blot analyses of skin biopsies revealed a strong upregulation of COX-2, a slight decrease of COX-1 and activation of nuclear factor kappa B (NF-kappaB) in the area of the freezing injury.

Positive_regulation (upregulation) of Positive_regulation (activation) of NF-kappaB in skin associated with injury

12) Confidence 0.49 Published 2007 Journal Pain Section Abstract Doc Link 17189672 Disease Relevance 0.63 Pain Relevance 0.85

Activation of NMDA receptors will also lead to activation of the early gene transcription factors including AP-1 (c-fos, c-jun) and NF-kappaB which may play a role in modulation of the subsequent response to hypoxia.

Positive_regulation (lead) of Positive_regulation (activation) of NF-kappaB associated with hypoxia and nmda receptor

13) Confidence 0.49 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15950554 Disease Relevance 0.34 Pain Relevance 0.71

Recombinant alphahCG or epidermal growth factor (EGF), a contaminant of some urinary hCG preparations, did not alter cytokine-dependent NF-kappaB activation.

Neg (not) Positive_regulation (cytokine-dependent) of Positive_regulation (activation) of NF-kappaB associated with cytokine

14) Confidence 0.47 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.64 Pain Relevance 0.26

The data suggest that hCG attenuates inflammation-dependent NF-kappaB activation and cytokine expression that could provide one explanation for the beneficial role of the hormone in endometriotic patients.

Positive_regulation (inflammation-dependent) of Positive_regulation (activation) of NF-kappaB associated with endometriosis, inflammation and cytokine

15) Confidence 0.47 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.38 Pain Relevance 0.17

Downregulation of constitutive and induced NF-kappaB activation in malignant melanoma cells leads to inhibition of IL-8 production and in vitro cell proliferation.

Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB associated with skin cancer

16) Confidence 0.46 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.75 Pain Relevance 0.38

We conclude that environmental and endogenous factors induce NF-kappaB activation mediated through expression of inflammatory cytokine genes, such as TNF-alpha, and that the expression pattern of the genes operates similarly in the aging process.

Positive_regulation (mediated) of Positive_regulation (activation) of NF-kappaB associated with aging, inflammation and cytokine

17) Confidence 0.46 Published 2002 Journal Mech. Ageing Dev. Section Abstract Doc Link 12470903 Disease Relevance 1.12 Pain Relevance 0.58

We conclude that environmental and endogenous factors induce NF-kappaB activation mediated through expression of inflammatory cytokine genes, such as TNF-alpha, and that the expression pattern of the genes operates similarly in the aging process.

Positive_regulation (induce) of Positive_regulation (activation) of NF-kappaB associated with aging, inflammation and cytokine

18) Confidence 0.46 Published 2002 Journal Mech. Ageing Dev. Section Abstract Doc Link 12470903 Disease Relevance 1.12 Pain Relevance 0.58

Ceramide up-regulates COX-2 transcription by increasing activation of transcription factor NF-kappaB.

Positive_regulation (increasing) of Positive_regulation (activation) of NF-kappaB

19) Confidence 0.45 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.11 Pain Relevance 0.05

These findings indicate that activation of NF-kappaB is responsible for TNF-alpha-induced COX-2 expression in synovial fibroblasts from the TMJ.

Positive_regulation (responsible) of Positive_regulation (activation) of NF-kappaB in TMJ associated with snapping jaw

20) Confidence 0.45 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17384033 Disease Relevance 0.56 Pain Relevance 0.35

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