INT66209

Context Info Confidence 0.58 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 23 Total Number 23 Disease Relevance 8.20 Pain Relevance 5.31

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1) cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)

Anatomy Link Frequency endothelial cell 2 monocytes 2 T98G 2 nucleus 2 NFKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 276 99.82 Paracetamol 12 99.78 qutenza 12 99.50 cINOD 14 99.28 COX2 9 98.68 cytokine 72 98.40 Inflammatory stimuli 14 97.72 rheumatoid arthritis 60 95.52 Inflammatory marker 6 95.28 metalloproteinase 6 94.32

Disease Link Frequency Relevance Heat INFLAMMATION 340 99.82 Esophageal Cancer 4 99.70 Apoptosis 35 99.16 Cancer 63 95.64 Skin Cancer 6 91.24 Melanoma 2 90.00 Premature Aging 2 88.08 Rheumatoid Arthritis 60 87.68 Age-related Macular Degeneration 4 87.68 Burns 4 86.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, these results indicate that anti-inflammatory drugs differ largely in their ability to inhibit NF-kappaB activity and/or TNF-alpha release from human monocytes.

Negative_regulation (inhibit) of Localization (release) of NF-kappaB in monocytes associated with inflammation and cinod

1) Confidence 0.58 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.62 Pain Relevance 0.46

Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.

Negative_regulation (blocking) of Localization (translocation) of NF-kappa B

2) Confidence 0.57 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.47 Pain Relevance 0.29

These inhibitions appeared to correlate with the suppression of NF-kappaB activation by harpagoside, as pre-treating cells with harpagoside blocked the translocation of NF-kappaB into the nuclear compartments and degradation of the inhibitory subunit IkappaB-alpha.

Negative_regulation (blocked) of Localization (translocation) of NF-kappaB

3) Confidence 0.56 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.23 Pain Relevance 0.32

Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.

Negative_regulation (blocked) of Localization (translocation) of NF-kappa B associated with qutenza

4) Confidence 0.55 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.05 Pain Relevance 0.76

These changes correlate with a reduction in COX-2 mRNA and protein expression, prostaglandin synthesis, an inhibition of NF-kappaB nuclear translocation, and an increase in cytoplasmic IkappaB.

Negative_regulation (inhibition) of Localization (translocation) of NF-kappaB

5) Confidence 0.54 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.66 Pain Relevance 0

NFkappaB translocation at reperfusion was reduced in stable preconditioned and unstable control patients compared to stable controls.

Negative_regulation (reduced) of Localization (translocation) of NFkappaB

6) Confidence 0.50 Published 2008 Journal Eur J Cardiothorac Surg Section Body Doc Link 18842422 Disease Relevance 0 Pain Relevance 0

These data indicate that therapeutic concentrations of acetaminophen induce an inhibition of IL-1beta-dependent NF-kappaB nuclear translocation.

Negative_regulation (inhibition) of Localization (translocation) of NF-kappaB associated with paracetamol

7) Confidence 0.44 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.48

Western blot analysis of IkappaBalpha protein in the cytoplasm of IL-1beta-stimulated T98G cells and electrophoretic mobility shift assay (EMSA) on corresponding nuclear extracts indicate that acetaminophen (10-1000 microM) dose-dependently inhibits both IkappaBalpha degradation and NF-kappaB nuclear translocation.

Negative_regulation (inhibits) of Localization (translocation) of NF-kappaB in T98G associated with paracetamol

8) Confidence 0.44 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.48

Western blot analyses revealed that hCG-A impaired TNF-alpha-mediated phosphorylation and degradation of the inhibitor IkappaBalpha suggesting that the hormone may reduce nuclear import of NF-kappaB by stabilizing its inhibitor.

Negative_regulation (reduce) of Localization (import) of NF-kappaB

9) Confidence 0.40 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.29 Pain Relevance 0.17

IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.

Negative_regulation (inhibition) of Localization (translocation) of NF-kappaB

10) Confidence 0.40 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.05 Pain Relevance 0

NS-398 induces apoptosis in human esophageal cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2.

Negative_regulation (inhibition) of Localization (regulation) of NF-kappaB associated with cox2, esophageal cancer and apoptosis

11) Confidence 0.39 Published 2009 Journal Cancer Invest. Section Title Doc Link 19160097 Disease Relevance 0.96 Pain Relevance 0.34

Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.

Negative_regulation (suppressed) of Localization (translocation) of NF-kappaB

12) Confidence 0.35 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 0.99 Pain Relevance 0.35

HA also decreased the degree of phosphorylation and nuclear translocation of NF-kappaB enhanced by LPS.

Negative_regulation (decreased) of Localization (translocation) of NF-kappaB

13) Confidence 0.35 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.50 Pain Relevance 0.39

The suppressive effect of SP600125 on the reduced nuclear translocation of the p50 subunits was also confirmed by examination with confocal laser scanning microscopy in Raw 264.7 cells (Fig. 3C).

Negative_regulation (reduced) of Localization (translocation) of p50

14) Confidence 0.35 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0

, leading to its degradation and thereby allowing the translocation of p50/p65 in the nucleus [27].

Negative_regulation (allowing) of Localization (translocation) of p50 in nucleus

15) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0.15 Pain Relevance 0.04

Finally, FP displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation.

Negative_regulation (decreasing) of Localization (translocation) of NF-kappaB associated with inflammation

16) Confidence 0.28 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11673549 Disease Relevance 0.57 Pain Relevance 0.47

B is the inhibition of the nuclear translocation of p50 and p65 through the blockage of I?

Negative_regulation (inhibition) of Localization (translocation) of p50

17) Confidence 0.25 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0

B is the inhibition of the nuclear translocation of p50 and p65 through the blockage of I?

Negative_regulation (blockage) of Localization (translocation) of p50

18) Confidence 0.25 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0

B by western blotting as well as translocation of p50, a subunit of NF-?

Negative_regulation (blotting) of Localization (translocation) of p50

19) Confidence 0.25 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.14 Pain Relevance 0.04

B activation by preventing p50 translocation via an interaction between melittin and sulfhydryl group of p50 and/or IKK?

Negative_regulation (preventing) of Localization (translocation) of p50

20) Confidence 0.25 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.60 Pain Relevance 0.30

General Comments

This test has worked.