INT66210

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 16
Total Number 20
Disease Relevance 9.46
Pain Relevance 7.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
chondrocytes 4
monocytes 4
blood 2
neurons 2
TMJ 2
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 34 100.00 Very High Very High Very High
Inflammation 17 100.00 Very High Very High Very High
Morphine 10 100.00 Very High Very High Very High
dexamethasone 7 99.34 Very High Very High Very High
aspirin 11 99.06 Very High Very High Very High
antagonist 4 98.68 Very High Very High Very High
cytokine 7 98.44 Very High Very High Very High
substance P 11 97.88 Very High Very High Very High
Snapping jaw 4 97.08 Very High Very High Very High
chemokine 2 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 32 100.00 Very High Very High Very High
Skin Cancer 39 99.84 Very High Very High Very High
Adhesions 3 98.56 Very High Very High Very High
Necrosis 12 98.24 Very High Very High Very High
Cancer 27 98.06 Very High Very High Very High
Apoptosis 8 97.16 Very High Very High Very High
Temporomandibular Joint Syndrome 4 97.08 Very High Very High Very High
Malignant Neoplastic Disease 2 96.12 Very High Very High Very High
Metastasis 3 94.12 High High
Rheumatoid Arthritis 6 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
Neg (no) Regulation (effects) of Positive_regulation (activation) of NF-kappa B
1) Confidence 0.60 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.19 Pain Relevance 0.24
Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation.
Regulation (Regulation) of Positive_regulation (activation) of NF-kappaB associated with qutenza and skin cancer
2) Confidence 0.57 Published 2002 Journal J. Interferon Cytokine Res. Section Title Doc Link 12034025 Disease Relevance 0.64 Pain Relevance 0.47
METHODS: The effects of diacerein, celecoxib, diclofenac, meloxicam and indomethacin on prostaglandin (PG) E2 production, cyclo-oxygenase-2 (COX-2) protein expression, nitrite levels, presence of MMP-1 and -13, and activation of nuclear factor-kappaB (NF-kappaB) were studied on stimulated OA synoviocytes and chondrocytes.
Regulation (effects) of Positive_regulation (activation) of NF-kappaB in chondrocytes
3) Confidence 0.56 Published 2008 Journal Rheumatology (Oxford) Section Body Doc Link 18375401 Disease Relevance 0.10 Pain Relevance 0
NF-kappaB activation was not a nonspecific response of all transcription factors because neither Sp1 or Oct1 was activated in patients with activated NF-kappaB.
Neg (not) Regulation (response) of Positive_regulation (activation) of NF-kappaB
4) Confidence 0.45 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0.10 Pain Relevance 0
We investigated the ability of dexamethasone, indomethacin, and rofecoxib to modulate nuclear factor-kappaB (NF-kappaB) activation and TNF-alpha release from human monocytes challenged with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA).
Regulation (modulate) of Positive_regulation (activation) of nuclear factor-kappaB in monocytes associated with dexamethasone
5) Confidence 0.44 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.66 Pain Relevance 0.38
We investigated the ability of dexamethasone, indomethacin, and rofecoxib to modulate nuclear factor-kappaB (NF-kappaB) activation and TNF-alpha release from human monocytes challenged with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA).
Regulation (modulate) of Positive_regulation (activation) of NF-kappaB in monocytes associated with dexamethasone
6) Confidence 0.44 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.66 Pain Relevance 0.38
Investigation of the mechanism responsible for morphine-induced activation of NF-kappaB promoter in NT2-N neurons demonstrated that morphine activates the SP promoter and induces SP expression in these cells.
Regulation (responsible) of Positive_regulation (activation) of NF-kappaB promoter in neurons associated with substance p and morphine
7) Confidence 0.44 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 14743438 Disease Relevance 0.07 Pain Relevance 1.79
These findings indicate that activation of NF-kappaB is responsible for TNF-alpha-induced COX-2 expression in synovial fibroblasts from the TMJ.
Regulation (responsible) of Positive_regulation (activation) of NF-kappaB in TMJ associated with snapping jaw
8) Confidence 0.43 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17384033 Disease Relevance 0.56 Pain Relevance 0.35
In the present study, we examined the effect of capsaicin and its analogue, resiniferatoxin, on the activation of NF-kappa B induced by different agents including TNF.
Spec (examined) Regulation (effect) of Spec (examined) Positive_regulation (activation) of NF-kappa B associated with qutenza
9) Confidence 0.42 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.08 Pain Relevance 0.60
In the present study, we demonstrate that upregulation of interleukin-1beta(IL-1beta)-mediated and tumor necrosis factor-alpha (TNF-alpha)-mediated IL-8 expression in human malignant melanoma cells is modulated by the activation of nuclear factor-kappaB (NF-kappaB).
Regulation (modulated) of Positive_regulation (activation) of NF-kappaB associated with necrosis, cancer and skin cancer
10) Confidence 0.42 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.58 Pain Relevance 0.30
In the present study, we demonstrate that upregulation of interleukin-1beta(IL-1beta)-mediated and tumor necrosis factor-alpha (TNF-alpha)-mediated IL-8 expression in human malignant melanoma cells is modulated by the activation of nuclear factor-kappaB (NF-kappaB).
Regulation (modulated) of Positive_regulation (activation) of nuclear factor-kappaB associated with necrosis, cancer and skin cancer
11) Confidence 0.42 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.57 Pain Relevance 0.30
These results demonstrate that constitutive and induced NF-kappaB activation regulates IL-8 expression in melanoma cells.
Regulation (regulates) of Positive_regulation (activation) of NF-kappaB associated with skin cancer
12) Confidence 0.42 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.68 Pain Relevance 0.40
METHODS: The effects of diacerein, celecoxib, diclofenac, meloxicam and indomethacin on prostaglandin (PG) E2 production, cyclo-oxygenase-2 (COX-2) protein expression, nitrite levels, presence of MMP-1 and -13, and activation of nuclear factor-kappaB (NF-kappaB) were studied on stimulated OA synoviocytes and chondrocytes.
Regulation (effects) of Positive_regulation (activation) of nuclear factor-kappaB in chondrocytes
13) Confidence 0.41 Published 2008 Journal Rheumatology (Oxford) Section Body Doc Link 18375401 Disease Relevance 0.10 Pain Relevance 0
Several cytokines, reactive oxygen species (ROS) and mediators of inflammatory pathway such as activation of nuclear factor-kappaB (NF-kappaB) and COX-2 leads to an increase in cell proliferation, survival, and inhibition of pro-apoptotic pathway, ultimately resulting in tumor angiogenesis, invasion and metastasis.
Regulation (leads) of Positive_regulation (activation) of nuclear factor-kappaB associated with inflammation, cancer, apoptosis, metastasis and cytokine
14) Confidence 0.37 Published 2007 Journal Mini Rev Med Chem Section Abstract Doc Link 17584158 Disease Relevance 1.49 Pain Relevance 0.39
Several cytokines, reactive oxygen species (ROS) and mediators of inflammatory pathway such as activation of nuclear factor-kappaB (NF-kappaB) and COX-2 leads to an increase in cell proliferation, survival, and inhibition of pro-apoptotic pathway, ultimately resulting in tumor angiogenesis, invasion and metastasis.
Regulation (leads) of Positive_regulation (activation) of NF-kappaB associated with inflammation, cancer, apoptosis, metastasis and cytokine
15) Confidence 0.37 Published 2007 Journal Mini Rev Med Chem Section Abstract Doc Link 17584158 Disease Relevance 1.49 Pain Relevance 0.39
To further characterize the biochemical inhibitory mechanisms of AM404, we examined the signaling pathways that regulate the activation of the transcription factors NF-kappaB, NFAT and AP-1 in Jurkat cells.
Spec (examined) Regulation (regulate) of Spec (examined) Positive_regulation (activation) of NF-kappaB
16) Confidence 0.33 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17196940 Disease Relevance 0 Pain Relevance 0.19
The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on TNF-alpha-induced activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and upregulation of intercellular adhesion molecule-1 (ICAM-1), and TNF-alpha-stimulated cell migration and invasion through fibronectin.
Spec (investigate) Regulation (effect) of Positive_regulation (activation) of NF-kappaB associated with inflammation and adhesions
17) Confidence 0.33 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.70 Pain Relevance 0.05
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Regulation (regulation) of Positive_regulation (activation) of NF-kappaB associated with aspirin
18) Confidence 0.32 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.64 Pain Relevance 0.66
METHODS: The influence of morphine on NF-kappaB activation was investigated in a whole-blood flow cytometric assay.
Regulation (influence) of Spec (investigated) Positive_regulation (activation) of NF-kappaB in blood
19) Confidence 0.26 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0
Involvement of mitogen-activated protein kinase and NF-kappaB activation in Ca2+-induced IL-8 production in human mast cells.
Regulation (Involvement) of Positive_regulation (activation) of NF-kappaB in mast cells
20) Confidence 0.20 Published 2005 Journal Cytokine Section Title Doc Link 16343928 Disease Relevance 0.16 Pain Relevance 0.19

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