INT66211

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Context Info
Confidence 0.68
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 8.18
Pain Relevance 5.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
monocytes 4
nucleus 2
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 22 99.84 Very High Very High Very High
narcan 1 99.04 Very High Very High Very High
qutenza 10 98.20 Very High Very High Very High
opioid receptor 1 97.92 Very High Very High Very High
cytokine 104 96.68 Very High Very High Very High
antagonist 4 96.64 Very High Very High Very High
cINOD 19 95.00 High High
COX2 4 94.12 High High
Morphine 8 94.08 High High
Inflammatory marker 9 91.84 High High
Disease Link Frequency Relevance Heat
Cancer 84 95.72 Very High Very High Very High
Adhesions 35 95.12 Very High Very High Very High
Apoptosis 45 94.84 High High
INFLAMMATION 344 94.76 High High
Skin Cancer 6 91.24 High High
Necrosis 28 90.40 High High
Melanoma 3 90.00 High High
Premature Aging 3 88.08 High High
Burns 6 86.88 High High
Disease 85 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both stimuli induced NF-kappaB nuclear translocation and TNF-alpha secretion.
Positive_regulation (induced) of Localization (secretion) of NF-kappaB
1) Confidence 0.68 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.69 Pain Relevance 0.43
HA also decreased the degree of phosphorylation and nuclear translocation of NF-kappaB enhanced by LPS.
Positive_regulation (enhanced) of Localization (translocation) of NF-kappaB
2) Confidence 0.56 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.48 Pain Relevance 0.38
We determined that increased Ca(2+) activates the nuclear translocation of the transcription factor NF-kappaB.
Positive_regulation (activates) of Localization (translocation) of NF-kappaB
3) Confidence 0.52 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.16 Pain Relevance 0.20
Both stimuli induced NF-kappaB nuclear translocation and TNF-alpha secretion.
Positive_regulation (induced) of Localization (translocation) of NF-kappaB
4) Confidence 0.46 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.68 Pain Relevance 0.43
We have recently demonstrated that constitutively active nuclear factor-kappa B (NF-kappaB) is responsible for the increased secretion of uPA and that inhibition of NF-kappaB suppresses secretion of uPA and cell migration of highly invasive cancer cells.
Positive_regulation (increased) of Localization (secretion) of nuclear factor-kappa B associated with cancer
5) Confidence 0.44 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.97 Pain Relevance 0.27
We have recently demonstrated that constitutively active nuclear factor-kappa B (NF-kappaB) is responsible for the increased secretion of uPA and that inhibition of NF-kappaB suppresses secretion of uPA and cell migration of highly invasive cancer cells.
Positive_regulation (increased) of Localization (secretion) of NF-kappaB associated with cancer
6) Confidence 0.44 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.96 Pain Relevance 0.27
Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.
Positive_regulation (essential) of Localization (translocation) of NF-kappa B associated with qutenza
7) Confidence 0.44 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.05 Pain Relevance 0.75
We found that celecoxib and PSC833, but not indomethacin or NS398, almost completely inhibited basal- and dox induced NF-kappaB gene-reporter activity and p65 subunit nuclear translocation.
Positive_regulation (induced) of Localization (translocation) of NF-kappaB
8) Confidence 0.42 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17097285 Disease Relevance 0.06 Pain Relevance 0.12
Activated NFKB1 trans-locates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions.
Positive_regulation (Activated) of Localization (locates) of NFKB1 in nucleus
9) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.24 Pain Relevance 0.13
Treatment with LPS increased nuclear translocation of p50 and p65.
Positive_regulation (increased) of Localization (translocation) of p50
10) Confidence 0.37 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1874678 Disease Relevance 0.11 Pain Relevance 0.08
Sickle monocytes triggered endothelial nuclear factor-kappa B (NF-kappaB) nuclear translocation.
Positive_regulation (triggered) of Localization (translocation) of nuclear factor-kappa B in monocytes
11) Confidence 0.35 Published 2000 Journal Blood Section Abstract Doc Link 11001897 Disease Relevance 0.77 Pain Relevance 0.09
It also induced the release of NO and activated NF-kappaB in HUVECs.
Positive_regulation (induced) of Localization (release) of NF-kappaB
12) Confidence 0.34 Published 2009 Journal Toxicology Section Abstract Doc Link 19070643 Disease Relevance 0.57 Pain Relevance 0.94
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Positive_regulation (increases) of Localization (translocation) of NF-kappaB in monocytes
13) Confidence 0.32 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.25
Unlike IL-1beta, NS-398 and Cig did not cause NF-kappaB (p65) nuclear translocation, nor did they further enhance IL-1beta-induced NF-kappaB translocation, but they stimulated PPARgamma translocation.
Neg (nor) Positive_regulation (enhance) of Localization (translocation) of NF-kappaB
14) Confidence 0.31 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.07 Pain Relevance 0.36
Pretreatment (1 hr) of SP600125 suppressed the inhibitory effect of melittin and bee venom on LPS and SNP-induced nuclear translocation of the p50 and p65 in Raw 264.7 cells (Fig. 3A) and in synoviocytes (Fig. 3B).
Positive_regulation (induced) of Localization (translocation) of p50
15) Confidence 0.30 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0
B by western blotting as well as translocation of p50, a subunit of NF-?
Positive_regulation (by) of Localization (translocation) of p50
16) Confidence 0.30 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.14 Pain Relevance 0.04
NF-kappaB nuclear translocation and IL-6 secretion induced by UVB and UVA were dramatically inhibited by treatment of EGCG [176].
Positive_regulation (induced) of Localization (secretion) of NF-kappaB
17) Confidence 0.13 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.87 Pain Relevance 0.09
In one study Ang II treatment induced IL-6 transcription by inducing cytoplasmic-to-nuclear translocation of the NF-kappaB subunits Rel A and NF-kappaB1 with parallel changes in DNA-binding activity in a biphasic manner, which produced an early peak at 15 minutes followed by a nadir 1 to 6 hours later and a later peak at 24 hours [60].


Positive_regulation (inducing) of Localization (translocation) of NF-kappaB
18) Confidence 0.13 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.20 Pain Relevance 0.10
NF-kappaB nuclear translocation and IL-6 secretion induced by UVB and UVA were dramatically inhibited by treatment of EGCG [176].
Positive_regulation (induced) of Localization (translocation) of NF-kappaB
19) Confidence 0.09 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.87 Pain Relevance 0.09
Because LPS is known to stimulate inhibitor kappaB (IkappaB) kinase (IKK)-mediated phosphorylation of IkappaB followed by its degradation, which in turn induces nuclear factor (NF)-kappaB nuclear translocation leading to transcriptional activation of COX-2 gene, the effect of gamma-mangostin on the IKK/IkappaB cascade controlling the NF-kappaB activation was examined.
Positive_regulation (induces) of Localization (translocation) of kappaB
20) Confidence 0.02 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.15 Pain Relevance 0

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