INT66212

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.48
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELA) nucleoplasm (RELA) aging (RELA)
nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)
Anatomy Link Frequency
nucleus 4
chondrocytes 2
endothelial cells 2
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 56 100.00 Very High Very High Very High
COX2 4 100.00 Very High Very High Very High
qutenza 10 99.50 Very High Very High Very High
cINOD 23 93.96 High High
withdrawal 9 91.56 High High
Morphine 6 91.12 High High
cytokine 93 87.12 High High
Inflammation 145 86.36 High High
COX-2 inhibitor 31 86.32 High High
chemokine 20 62.48 Quite High
Disease Link Frequency Relevance Heat
Infection 104 97.52 Very High Very High Very High
Herpes Simplex Virus 238 97.12 Very High Very High Very High
Stomach Cancer 12 97.00 Very High Very High Very High
INFLAMMATION 167 93.76 High High
Chondrosarcoma 6 84.80 Quite High
Apoptosis 70 69.12 Quite High
Stress 2 68.76 Quite High
Sarcoma 79 50.00 Quite Low
Colon Cancer 44 50.00 Quite Low
Adhesions 43 27.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, SC236 worked directly through suppressing nuclear translocation of RelA/p65.
Negative_regulation (suppressing) of Localization (translocation) of RelA
1) Confidence 0.57 Published 2003 Journal Oncogene Section Abstract Doc Link 12606945 Disease Relevance 0.35 Pain Relevance 0.25
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.
Negative_regulation (Suppression) of Localization (translocation) of RelA associated with aspirin and stomach cancer
2) Confidence 0.57 Published 2003 Journal Oncogene Section Title Doc Link 12606945 Disease Relevance 0.42 Pain Relevance 0.31
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Negative_regulation (prevents) of Localization (translocation) of p65 in nucleus
3) Confidence 0.41 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.80
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.
Negative_regulation (Suppression) of Localization (translocation) of p65 associated with aspirin and stomach cancer
4) Confidence 0.41 Published 2003 Journal Oncogene Section Title Doc Link 12606945 Disease Relevance 0.42 Pain Relevance 0.31
Instead, SC236 worked directly through suppressing nuclear translocation of RelA/p65.
Negative_regulation (suppressing) of Localization (translocation) of p65
5) Confidence 0.41 Published 2003 Journal Oncogene Section Abstract Doc Link 12606945 Disease Relevance 0.35 Pain Relevance 0.25
, leading to its degradation and thereby allowing the translocation of p50/p65 in the nucleus [27].
Negative_regulation (allowing) of Localization (translocation) of p65 in nucleus
6) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0.15 Pain Relevance 0.04
This could explain the nuclear accumulation of p65 that we observe in chondrocytes treated with both molecules: by inhibiting IKK?
Negative_regulation (inhibiting) of Localization (accumulation) of p65 in chondrocytes
7) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
assessed by western blotting and translocation of the p65 subunit of NF-?
Negative_regulation (blotting) of Localization (translocation) of p65
8) Confidence 0.17 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0 Pain Relevance 0.11
B is the inhibition of the nuclear translocation of p50 and p65 through the blockage of I?
Negative_regulation (blockage) of Localization (translocation) of p65
9) Confidence 0.14 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0
B is the inhibition of the nuclear translocation of p50 and p65 through the blockage of I?
Negative_regulation (inhibition) of Localization (translocation) of p65
10) Confidence 0.14 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0
Taken together, these results suggest that inhibition of AKT1 extensively augments Par-4/p65 interactions in cytosol and consequently blocks nuclear translocation of p65.


Negative_regulation (blocks) of Localization (translocation) of p65
11) Confidence 0.12 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.13 Pain Relevance 0
Treatment of infected endothelial cells with Indo or NS-398 reduced the nuclear translocation of p65 (an indication of NF-?
Negative_regulation (reduced) of Localization (translocation) of p65 in endothelial cells
12) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.62 Pain Relevance 0.28
Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.
Negative_regulation (blocked) of Localization (translocation) of p65 subunit associated with qutenza
13) Confidence 0.06 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.05 Pain Relevance 0.76

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