INT66213

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 63
Total Number 68
Disease Relevance 14.71
Pain Relevance 8.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELA) nucleoplasm (RELA) aging (RELA)
nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)
Anatomy Link Frequency
nucleus 9
chondrocytes 1
macrophages 1
endothelial cells 1
neurons 1
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 11 99.84 Very High Very High Very High
aspirin 228 99.70 Very High Very High Very High
COX2 9 99.70 Very High Very High Very High
qutenza 17 98.20 Very High Very High Very High
Inflammation 543 97.10 Very High Very High Very High
Hippocampus 14 96.64 Very High Very High Very High
cINOD 100 95.68 Very High Very High Very High
dexamethasone 33 92.84 High High
Catechol-O-methyltransferase 222 92.72 High High
cytokine 268 92.48 High High
Disease Link Frequency Relevance Heat
Pancreatitis 11 99.84 Very High Very High Very High
Leukemia 59 99.04 Very High Very High Very High
Anaplastic Astrocytoma 16 97.44 Very High Very High Very High
Repression 29 97.40 Very High Very High Very High
INFLAMMATION 679 97.10 Very High Very High Very High
Stomach Cancer 18 97.00 Very High Very High Very High
Respiratory Syncytial Virus 232 96.76 Very High Very High Very High
Infection 107 96.72 Very High Very High Very High
Herpes Simplex Virus 240 96.32 Very High Very High Very High
Skin Cancer 5 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The translocation of RelA/p65 was investigated using Western blotting and immunocytochemistry.
Spec (investigated) Localization (translocation) of p65
1) Confidence 0.78 Published 2003 Journal Oncogene Section Abstract Doc Link 12606945 Disease Relevance 0.42 Pain Relevance 0.20
The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB.
Localization (translocation) of p65
2) Confidence 0.78 Published 2008 Journal Oncogene Section Title Doc Link 18059344 Disease Relevance 0.33 Pain Relevance 0.49
The change of PACAP-mediated anti-inflammatory pattern was associated with altered activation of NF-kappaB: compared with LPS alone, a combination of LPS and PACAP had no effect on NF-kappaB p65 nuclear translocation in CP PBMC, whereas NF-kappaB was significantly decreased in donor PBMC.
Localization (translocation) of p65 in PBMC associated with inflammation and chronic pancreatitis
3) Confidence 0.78 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 1.11 Pain Relevance 1.14
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.
Localization (translocation) of RelA associated with aspirin and stomach cancer
4) Confidence 0.78 Published 2003 Journal Oncogene Section Title Doc Link 12606945 Disease Relevance 0.42 Pain Relevance 0.31
Instead, SC236 worked directly through suppressing nuclear translocation of RelA/p65.
Localization (translocation) of p65
5) Confidence 0.78 Published 2003 Journal Oncogene Section Abstract Doc Link 12606945 Disease Relevance 0.34 Pain Relevance 0.25
Instead, SC236 worked directly through suppressing nuclear translocation of RelA/p65.
Localization (translocation) of RelA
6) Confidence 0.78 Published 2003 Journal Oncogene Section Abstract Doc Link 12606945 Disease Relevance 0.34 Pain Relevance 0.25
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.
Localization (translocation) of p65 associated with aspirin and stomach cancer
7) Confidence 0.78 Published 2003 Journal Oncogene Section Title Doc Link 12606945 Disease Relevance 0.42 Pain Relevance 0.31
The translocation of RelA/p65 was investigated using Western blotting and immunocytochemistry.
Spec (investigated) Localization (translocation) of RelA
8) Confidence 0.78 Published 2003 Journal Oncogene Section Abstract Doc Link 12606945 Disease Relevance 0.42 Pain Relevance 0.20
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Localization (translocation) of p65 in nucleus
9) Confidence 0.78 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.79
degradation to release p50/RelA and p50/c-Rel heterodimers and via the alternative or noncanonical pathway by promoting p100 processing into p52 [31].
Localization (release) of RelA
10) Confidence 0.73 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.22 Pain Relevance 0.04
M/mL and 70, 42, and 38% after incubation with antisense RelA p65 and NF-?
Localization (antisense) of RelA
11) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Mismatched antisense RelA p65 and NF-?
Localization (antisense) of RelA
12) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Mismatched antisense RelA p65 and NF-?
Localization (antisense) of p65
13) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
M/mL and 70, 42, and 38% after incubation with antisense RelA p65 and NF-?
Localization (antisense) of p65
14) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Simultaneous incubation of HCAEC with antisense RelA p65 and NF-?
Localization (incubation) of RelA
15) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
M/mL and 73, 73, and 70% after incubation with antisense RelA p65 and NF-?
Localization (antisense) of p65
16) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Mismatched antisense RelA p65 and NF-?
Localization (antisense) of p65
17) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Simultaneous incubation of HCAEC with antisense RelA p65 and NF-?
Localization (incubation) of p65
18) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
M/mL and 73, 73, and 70% after incubation with antisense RelA p65 and NF-?
Localization (antisense) of RelA
19) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Therefore it can be speculated that a simultaneous administration of antisense RelA p65 and NF-?
Localization (speculated) of p65
20) Confidence 0.68 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.12 Pain Relevance 0

General Comments

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