INT66225

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Context Info
Confidence 0.37
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.00
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (COX18) mitochondrion (COX18)
Anatomy Link Frequency
epithelium 2
PGE2 1
mononuclear cells 1
COX18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 97.08 Very High Very High Very High
cINOD 17 96.64 Very High Very High Very High
aspirin 7 94.96 High High
Inflammation 20 90.20 High High
Inflammatory response 4 89.96 High High
COX-2 inhibitor 3 86.92 High High
Kinase C 1 53.44 Quite High
antagonist 5 44.56 Quite Low
cytokine 7 31.52 Quite Low
chemokine 1 25.04 Quite Low
Disease Link Frequency Relevance Heat
Cleidocranial Dysplasia 6 98.80 Very High Very High Very High
Colon Cancer 4 98.72 Very High Very High Very High
Breast Cancer 14 97.52 Very High Very High Very High
Pain 2 97.08 Very High Very High Very High
INFLAMMATION 37 96.24 Very High Very High Very High
Toxicity 7 92.84 High High
Cancer 19 91.28 High High
Inflammatory Breast Neoplasms 34 82.68 Quite High
Esophageal Cancer 2 82.32 Quite High
Adenocarcinoma 2 77.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, COX-2 protein is increased in 41% of patients with Barrett's epithelium compared to normal esophageal mucosa but did not differ with or without dysplasia.
Positive_regulation (increased) of COX-2 protein in epithelium associated with cleidocranial dysplasia
1) Confidence 0.37 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11330414 Disease Relevance 0.57 Pain Relevance 0.07
Increased COX-2 protein was detected in Barrett's epithelium in seven patients (41%) but did not differ with or without dysplasia (43% vs 40%).
Positive_regulation (Increased) of COX-2 protein in epithelium associated with cleidocranial dysplasia
2) Confidence 0.37 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11330414 Disease Relevance 0.59 Pain Relevance 0.08
Cox-1 protein was detected in the human mononuclear cells at time zero but was not induced by either LPS or PBS.
Neg (not) Positive_regulation (induced) of Cox-1 protein in mononuclear cells
3) Confidence 0.31 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8907587 Disease Relevance 0.10 Pain Relevance 0.19
All the lines were positive for COX-1 protein and mRNA, as evaluated by Western blot and RT-PCR, respectively, while only one was positive for COX-2.
Positive_regulation (positive) of COX-1 protein
4) Confidence 0.28 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12738997 Disease Relevance 0.36 Pain Relevance 0.30
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Neg (no) Positive_regulation (effect) of COX-1 protein
5) Confidence 0.22 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.53 Pain Relevance 0.19
Mono Mac 6 cells express high amounts of COX-2 upon stimulation with lipopolysaccharide (LPS) in the absence of any detectable COX-1 protein.
Positive_regulation (absence) of COX-1 protein
6) Confidence 0.19 Published 1997 Journal J Pharmacol Toxicol Methods Section Abstract Doc Link 9279772 Disease Relevance 0.16 Pain Relevance 0.36
Bryostatin (1-10 nM) induced COX-2 mRNA, COX-2 protein, and prostaglandin biosynthesis.
Positive_regulation (induced) of COX-2 protein
7) Confidence 0.13 Published 2003 Journal Clin. Cancer Res. Section Abstract Doc Link 14581379 Disease Relevance 0.19 Pain Relevance 0.12
As a validation of the increased Cox-2 mRNA, we evaluated the levels of PGE2 production and Cox-2 protein produced by SUM149 and SUM190 (Figs. 5B and 5C).
Positive_regulation (increased) of Cox-2 protein
8) Confidence 0.01 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 1.34 Pain Relevance 0.08
Lipopolysaccharide (LPS) stimulated prostaglandin E2 (PGE2) formation and induction of cyclooxygenase-2 (COX-2) expression without changing the levels of COX-1 protein in rat peritoneal macrophages.
Neg (without) Positive_regulation (changing) of COX-1 protein in PGE2
9) Confidence 0.01 Published 1996 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9014225 Disease Relevance 0.17 Pain Relevance 0.46

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