INT66226

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Context Info
Confidence 0.31
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.41
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (COX18) mitochondrion (COX18)
Anatomy Link Frequency
mononuclear cells 6
PC-3 2
COX18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 24 99.54 Very High Very High Very High
Inflammation 28 98.84 Very High Very High Very High
COX2 7 98.54 Very High Very High Very High
cva 5 92.44 High High
COX-2 inhibitor 4 86.92 High High
Pain 2 73.12 Quite High
Osteoarthritis 44 33.52 Quite Low
cOX1 1 25.00 Low Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 13 99.90 Very High Very High Very High
Colorectal Cancer 12 99.84 Very High Very High Very High
INFLAMMATION 42 98.84 Very High Very High Very High
Reprotox - General 1 4 97.56 Very High Very High Very High
Abdominal Aortic Aneurysm 6 92.44 High High
Prostatic Intraepithelial Neoplasia 1 75.12 Quite High
Frailty 2 75.00 Quite High
Prostate Cancer 1 75.00 Quite High
Pressure And Volume Under Development 1 73.92 Quite High
Fever 1 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of human mononuclear cells isolated from whole blood with LPS (100 mu g/mL) induced a time-dependent increase in the expression of Cox-2 protein (>100 fold at 24 hr).
Positive_regulation (induced) of Gene_expression (expression) of Cox-2 protein in mononuclear cells
1) Confidence 0.31 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8907587 Disease Relevance 0.08 Pain Relevance 0.16
COX-2 protein is present at increased levels in the majority of human AAAs and is expressed by mononuclear cells in the inflammatory cell infiltrate.
Positive_regulation (increased) of Gene_expression (expressed) of COX-2 protein in mononuclear cells associated with inflammation
2) Confidence 0.27 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17349338 Disease Relevance 0.75 Pain Relevance 0.41
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Neg (no) Positive_regulation (effect) of Gene_expression (expressed) of COX-1 protein
3) Confidence 0.22 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.53 Pain Relevance 0.19
Incubation of human mononuclear cells isolated from whole blood with LPS (100 mu g/mL) induced a time-dependent increase in the expression of Cox-2 protein (>100 fold at 24 hr).
Positive_regulation (increase) of Gene_expression (expression) of Cox-2 protein in mononuclear cells
4) Confidence 0.21 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8907587 Disease Relevance 0.08 Pain Relevance 0.16
The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
Positive_regulation (induced) of Gene_expression (expression) of COX-2 protein associated with colorectal cancer, cinod, cox2 and apoptosis
5) Confidence 0.20 Published 2002 Journal Int. J. Cancer Section Title Doc Link 11992399 Disease Relevance 0.68 Pain Relevance 0.25
We have shown previously that NS-398, which selectively inhibits cyclooxygenase-2 (COX-2) over cyclooxygenase-1, induces apoptosis of colorectal tumour cells and elevates COX-2 protein expression.
Positive_regulation (elevates) of Gene_expression (expression) of COX-2 protein associated with colorectal cancer and apoptosis
6) Confidence 0.20 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.61 Pain Relevance 0.16
U0126, a specific inhibitor of the ERK-activating kinases MEK-1/-2, prevented the activation of ERK induced by NS-398 and blocked the increase in COX-2 protein expression seen when HT29 cells were treated with NS-398 alone.
Positive_regulation (increase) of Gene_expression (expression) of COX-2 protein
7) Confidence 0.20 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.61 Pain Relevance 0.27
Mono Mac 6 cells express high amounts of COX-2 upon stimulation with lipopolysaccharide (LPS) in the absence of any detectable COX-1 protein.
Positive_regulation (absence) of Gene_expression (detectable) of COX-1 protein
8) Confidence 0.19 Published 1997 Journal J Pharmacol Toxicol Methods Section Abstract Doc Link 9279772 Disease Relevance 0.16 Pain Relevance 0.36
M HNE, however, PGE2 release and COX-2 protein expression were enhanced after 4 hours of incubation, with maximum values obtained at 24 hours (Figure 1c, d).
Positive_regulation (enhanced) of Gene_expression (expression) of COX-2 protein
9) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.08 Pain Relevance 0
In the cell lines, LNCaP, DU145, PC-3, and TSU, COX-2 protein expression was undetectable under basal conditions but could be induced transiently by phorbol ester treatment in PC-3 and TSU cells, but not in DU145 and LNCaP cells.
Positive_regulation (induced) of Gene_expression (expression) of COX-2 protein in PC-3
10) Confidence 0.10 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11751373 Disease Relevance 0.82 Pain Relevance 0.15

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