INT66227

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 41
Total Number 47
Disease Relevance 26.91
Pain Relevance 6.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (COX18) mitochondrion (COX18)
Anatomy Link Frequency
mononuclear cells 4
liver 1
colon 1
PC-3 1
epithelium 1
COX18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 77 99.38 Very High Very High Very High
Inflammation 192 98.84 Very High Very High Very High
COX2 35 98.38 Very High Very High Very High
cva 20 92.44 High High
IPN 1 91.32 High High
Arthritis 7 90.44 High High
Inflammatory response 20 87.20 High High
Snapping jaw 4 86.64 High High
COX-2 inhibitor 23 86.32 High High
cytokine 34 75.56 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 12 99.96 Very High Very High Very High
Colon Cancer 98 99.92 Very High Very High Very High
Cancer 120 99.84 Very High Very High Very High
Colorectal Cancer 12 99.84 Very High Very High Very High
Apoptosis 100 99.74 Very High Very High Very High
Inflammatory Breast Neoplasms 68 99.66 Very High Very High Very High
Endometrial Cancer 40 99.56 Very High Very High Very High
Metastasis 36 99.04 Very High Very High Very High
Skin Cancer 21 99.00 Very High Very High Very High
INFLAMMATION 278 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COX-2 protein was expressed by cancer cells in all human colorectal cancer liver metastases which were studied.
Gene_expression (expressed) of COX-2 protein in liver associated with cancer, colon cancer and metastasis
1) Confidence 0.50 Published 2000 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11206834 Disease Relevance 1.34 Pain Relevance 0
There was no relationship between metastasis size or differentiation grade and the level of COX-2 protein expression.
Gene_expression (expression) of COX-2 protein associated with metastasis
2) Confidence 0.50 Published 2000 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11206834 Disease Relevance 1.31 Pain Relevance 0.07
Diffuse cytoplasmic staining for COX-2 protein was detected in cancer cells in 100% of metastases (COX-2 score 1, n = 25; score 2, n = 29).
Gene_expression (staining) of COX-2 protein associated with cancer and metastasis
3) Confidence 0.43 Published 2000 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11206834 Disease Relevance 1.15 Pain Relevance 0.08
Increased COX-2 protein was detected in Barrett's epithelium in seven patients (41%) but did not differ with or without dysplasia (43% vs 40%).
Gene_expression (detected) of COX-2 protein in epithelium associated with cleidocranial dysplasia
4) Confidence 0.42 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11330414 Disease Relevance 0.59 Pain Relevance 0.08
COX-2 protein is present at increased levels in the majority of human AAAs and is expressed by mononuclear cells in the inflammatory cell infiltrate.
Gene_expression (expressed) of COX-2 protein in mononuclear cells associated with inflammation
5) Confidence 0.41 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17349338 Disease Relevance 0.75 Pain Relevance 0.41
Expression of COX-2 protein varied widely between AAAs.
Gene_expression (Expression) of COX-2 protein
6) Confidence 0.41 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17349338 Disease Relevance 0.74 Pain Relevance 0.40
COX-2 protein is present at increased levels in the majority of human AAAs and is expressed by mononuclear cells in the inflammatory cell infiltrate.
Gene_expression (present) of COX-2 protein in mononuclear cells associated with inflammation
7) Confidence 0.41 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17349338 Disease Relevance 0.75 Pain Relevance 0.41
COX-2 protein was detected in 46 of 49 (94%) human AAAs.
Gene_expression (detected) of COX-2 protein
8) Confidence 0.41 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17349338 Disease Relevance 0.74 Pain Relevance 0.39
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Gene_expression (expressed) of COX-1 protein
9) Confidence 0.37 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.52 Pain Relevance 0.19
COX-2 protein was undetectable in normal esophageal mucosa.
Gene_expression (undetectable) of COX-2 protein
10) Confidence 0.36 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11330414 Disease Relevance 0.59 Pain Relevance 0.08
Expression of the Cox-2 protein was also seen in all 11 squamous cell carcinomas studied, although the level of staining seemed to be less than that in the adenocarcinomas.
Gene_expression (Expression) of Cox-2 protein associated with adenocarcinoma and skin cancer
11) Confidence 0.35 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9823297 Disease Relevance 1.58 Pain Relevance 0.13
Interestingly, atypical alveolar epithelium, which associates with asbestosis and idiopathic fibrosing alveolitis and is considered to be a precursor lesion for lung cancer, expressed the Cox-2 protein.
Gene_expression (expressed) of Cox-2 protein in lung associated with lung cancer, pulmonary fibrosis and occupational lung diseases
12) Confidence 0.35 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9823297 Disease Relevance 1.39 Pain Relevance 0.05
Cox-1 protein was detected in the human mononuclear cells at time zero but was not induced by either LPS or PBS.
Gene_expression (detected) of Cox-1 protein in mononuclear cells
13) Confidence 0.34 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8907587 Disease Relevance 0.09 Pain Relevance 0.18
Incubation of human mononuclear cells isolated from whole blood with LPS (100 mu g/mL) induced a time-dependent increase in the expression of Cox-2 protein (>100 fold at 24 hr).
Gene_expression (expression) of Cox-2 protein in mononuclear cells
14) Confidence 0.34 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8907587 Disease Relevance 0.08 Pain Relevance 0.16
RESULTS: COX-2 protein was expressed in both of the cell lines.
Gene_expression (expressed) of COX-2 protein
15) Confidence 0.31 Published 2003 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 12921553 Disease Relevance 0.14 Pain Relevance 0
METHODS: Streptovidin peroxidase conjugated (SP) immunohistochemical assay was performed to examine the expression of COX-2 protein in human ovarian epithelial serous cancer cell lines CAOV3 and OVCAR3 respectively.
Spec (examine) Gene_expression (expression) of COX-2 protein
16) Confidence 0.31 Published 2003 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 12921553 Disease Relevance 0.18 Pain Relevance 0
On the other hand, we find HEL cells to naturally express COX-1 protein, but not COX-2.
Neg (not) Gene_expression (express) of COX-1 protein in HEL
17) Confidence 0.29 Published 1997 Journal J Pharmacol Toxicol Methods Section Abstract Doc Link 9279772 Disease Relevance 0.16 Pain Relevance 0.36
Mono Mac 6 cells express high amounts of COX-2 upon stimulation with lipopolysaccharide (LPS) in the absence of any detectable COX-1 protein.
Gene_expression (detectable) of COX-1 protein
18) Confidence 0.25 Published 1997 Journal J Pharmacol Toxicol Methods Section Abstract Doc Link 9279772 Disease Relevance 0.16 Pain Relevance 0.36
U0126, a specific inhibitor of the ERK-activating kinases MEK-1/-2, prevented the activation of ERK induced by NS-398 and blocked the increase in COX-2 protein expression seen when HT29 cells were treated with NS-398 alone.
Gene_expression (expression) of COX-2 protein
19) Confidence 0.22 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.61 Pain Relevance 0.27
We have shown previously that NS-398, which selectively inhibits cyclooxygenase-2 (COX-2) over cyclooxygenase-1, induces apoptosis of colorectal tumour cells and elevates COX-2 protein expression.
Gene_expression (expression) of COX-2 protein associated with colorectal cancer and apoptosis
20) Confidence 0.22 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.61 Pain Relevance 0.16

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