INT6623

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2011
Negated 6
Speculated 5
Reported most in Abstract
Documents 231
Total Number 238
Disease Relevance 45.78
Pain Relevance 59.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 10
neurons 9
astrocytes 8
nerve 8
heart 6
NA (Homo sapiens)
NA - E161K (1)
Pain Link Frequency Relevance Heat
tetrodotoxin 1087 100.00 Very High Very High Very High
sodium channel 319 100.00 Very High Very High Very High
Nucleus accumbens 113 100.00 Very High Very High Very High
Spinal cord 79 100.00 Very High Very High Very High
Hippocampus 69 100.00 Very High Very High Very High
noradrenaline 25 100.00 Very High Very High Very High
nociceptor 17 100.00 Very High Very High Very High
Opioid 5 99.98 Very High Very High Very High
dorsal root ganglion 94 99.86 Very High Very High Very High
5HT 25 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 90 100.00 Very High Very High Very High
Hyperinsulinism 2 99.92 Very High Very High Very High
Ganglion Cysts 107 99.86 Very High Very High Very High
Inflammatory Bowel Disease 110 99.84 Very High Very High Very High
Congenital Anomalies 74 99.84 Very High Very High Very High
Nociception 34 99.84 Very High Very High Very High
Recurrence 7 99.64 Very High Very High Very High
Pain 104 99.60 Very High Very High Very High
Brain Hemorrhage 442 99.56 Very High Very High Very High
Demyelinating Disease 30 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasticity of Na+ channel gene expression occurs in the normal nervous system, where it accompanies transitions between different physiological states (e.g. low-frequency versus high-frequency firing states) in some types of neurons.
Gene_expression (expression) of Na in neurons
1) Confidence 0.78 Published 2002 Journal Novartis Found. Symp. Section Abstract Doc Link 11771649 Disease Relevance 0.06 Pain Relevance 0.12
There is also recent evidence for the expression of normally silent Na+ channel genes in Purkinje cells in experimental models of demyelinating diseases and in a human disease, multiple sclerosis; this dysregulation of Na+ channel expression may interfere with neuronal function in these disorders.
Gene_expression (expression) of Na in Purkinje cells associated with multiple sclerosis, disease and demyelinating disease
2) Confidence 0.78 Published 2002 Journal Novartis Found. Symp. Section Abstract Doc Link 11771649 Disease Relevance 0.39 Pain Relevance 0.23
Exposure of the anoxic spinal cord to the Na+ channel blocker tetrodotoxin (TTX), the Na-Ca exchange blockers benzamil and bepridil, Na(+)-H+ exchange blockers amiloride and harmaline, and perfusion in Ringer solution with pH adjusted to 6.4, all resulted in improved recovery.
Gene_expression (Exposure) of Na in spinal cord associated with tetrodotoxin and spinal cord
3) Confidence 0.66 Published 1997 Journal J. Neurotrauma Section Abstract Doc Link 9199396 Disease Relevance 0.36 Pain Relevance 0.67
To extend understanding of this protection we are seeking a possible binding site for the PUFAs on the alpha-subunit of the human cardiac Na+ channel, hH1alpha, transiently expressed in HEK293t cells.
Gene_expression (expressed) of Na
4) Confidence 0.64 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11178958 Disease Relevance 0.09 Pain Relevance 0.13
Pharmacological modulation of human sodium current was examined in Xenopus oocytes expressing human heart Na+ channels.
Gene_expression (expressing) of Na in heart
5) Confidence 0.61 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8174607 Disease Relevance 0 Pain Relevance 0.19
Maladaptive changes in Na+ channel gene expression also occur in some pathological neurons.
Gene_expression (expression) of Na in neurons
6) Confidence 0.60 Published 2002 Journal Novartis Found. Symp. Section Abstract Doc Link 11771649 Disease Relevance 0.26 Pain Relevance 0.18
Exposure of the anoxic spinal cord to the Na+ channel blocker tetrodotoxin (TTX), the Na-Ca exchange blockers benzamil and bepridil, Na(+)-H+ exchange blockers amiloride and harmaline, and perfusion in Ringer solution with pH adjusted to 6.4, all resulted in improved recovery.
Gene_expression (Exposure) of Na in spinal cord associated with tetrodotoxin and spinal cord
7) Confidence 0.57 Published 1997 Journal J. Neurotrauma Section Abstract Doc Link 9199396 Disease Relevance 0.37 Pain Relevance 0.68
Together, the findings indicate functional expression of amiloride-sensitive Na+/H+-antiporters, which enable the nociceptive nerve endings to extrude invading H+.
Gene_expression (expression) of Na in nerve associated with nociception
8) Confidence 0.57 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10457175 Disease Relevance 0.32 Pain Relevance 0.49
[Elementary properties and the interaction of single myocardial Na+ channels with antiarrhythmic drugs].
Gene_expression (single) of Na
9) Confidence 0.56 Published 1989 Journal Arzneimittelforschung Section Title Doc Link 2541732 Disease Relevance 0 Pain Relevance 0.09
In our routine screening of chemicals that would inhibit cardiac sarcolemmal Na+/H+ antiporter, we discovered that some of the opioids produced inhibition of cardiac sarcolemmal Na+/H+ antiporter in micromolar concentrations.
Gene_expression (produced) of Na associated with opioid
10) Confidence 0.56 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1333352 Disease Relevance 0 Pain Relevance 0.39
The diversity and dynamic nature of Na+ channel expression introduce a high degree of complexity into the nervous system and present challenges for neuroscientists.
Gene_expression (expression) of Na in nervous system
11) Confidence 0.53 Published 2002 Journal Novartis Found. Symp. Section Abstract Doc Link 11771649 Disease Relevance 0.37 Pain Relevance 0.21
For example, transection of the peripheral axons of spinal sensory neurons triggers downregulation of some Na+ channel genes and up-regulation of others, resulting in changes in Na+ current expression that produce hyperexcitability, thereby contributing to chronic pain.
Gene_expression (expression) of Na in sensory neurons associated with lasting pain and hyperexcitability
12) Confidence 0.53 Published 2002 Journal Novartis Found. Symp. Section Abstract Doc Link 11771649 Disease Relevance 0.34 Pain Relevance 0.23
There is also recent evidence for the expression of normally silent Na+ channel genes in Purkinje cells in experimental models of demyelinating diseases and in a human disease, multiple sclerosis; this dysregulation of Na+ channel expression may interfere with neuronal function in these disorders.
Gene_expression (expression) of Na in Purkinje cells associated with multiple sclerosis, disease and demyelinating disease
13) Confidence 0.53 Published 2002 Journal Novartis Found. Symp. Section Abstract Doc Link 11771649 Disease Relevance 0.39 Pain Relevance 0.22
Moreover, the expression of Na+ channels within neurons is not a static process.
Gene_expression (expression) of Na in neurons
14) Confidence 0.53 Published 2002 Journal Novartis Found. Symp. Section Abstract Doc Link 11771649 Disease Relevance 0 Pain Relevance 0.06
The sodium channel Na(v)1.7 is preferentially expressed in nociceptive neurons and is believed to play a crucial role in pain sensation.
Gene_expression (expressed) of Na in neurons associated with nociception, pain and sodium channel
15) Confidence 0.53 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18337362 Disease Relevance 0.29 Pain Relevance 0.22
We report the expression of voltage-dependent Na+ channels in Xenopus oocytes injected with total RNA isolated from explanted human hearts.
Gene_expression (expression) of Na in hearts
16) Confidence 0.52 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 1690519 Disease Relevance 0 Pain Relevance 0.23
Na+ channels expressed by injection of human cardiac RNA into Xenopus oocytes qualitatively resemble channels in the native tissue.
Gene_expression (expressed) of Na in oocytes
17) Confidence 0.52 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 1690519 Disease Relevance 0 Pain Relevance 0.27
In contrast to IVCT- cells, IVCT+ cells expressed Na+ currents that were predominantly TTX sensitive even in the absence of added fatty acid, thus showing a relatively large baseline functional expression of SkM1 channels.
Gene_expression (expressed) of Na associated with tetrodotoxin
18) Confidence 0.52 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8760064 Disease Relevance 0.20 Pain Relevance 0.50
This region contains the gene SCN9A, encoding the alpha-subunit of the voltage-gated sodium channel, Na(v)1.7, which is strongly expressed in nociceptive neurons.
Gene_expression (expressed) of Na in neurons associated with nociception and sodium channel
19) Confidence 0.52 Published 2006 Journal Nature Section Abstract Doc Link 17167479 Disease Relevance 0.40 Pain Relevance 0.33
Voltage-gated Na+ channel (VGSC) expression has previously been shown to be upregulated in strongly metastatic prostate cancer cells (rat and human) and its activity shown to potentiate a variety of cellular behaviours integral to the metastatic cascade.
Gene_expression (expression) of Na associated with reprotox - general 1
20) Confidence 0.52 Published 2004 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15109569 Disease Relevance 0.23 Pain Relevance 0

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