INT6624

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Context Info
Confidence 0.76
First Reported 1981
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 135
Total Number 137
Disease Relevance 110.27
Pain Relevance 27.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
parathyroid 54
head 11
blood 5
plasma 3
pituitary 3
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 243 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
fibrosis 130 99.84 Very High Very High Very High
pruritus 101 99.80 Very High Very High Very High
Opioid 12 99.60 Very High Very High Very High
narcan 16 99.10 Very High Very High Very High
cytokine 34 98.84 Very High Very High Very High
Pain 158 96.90 Very High Very High Very High
Restless leg syndrome 2 96.12 Very High Very High Very High
tolerance 9 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoporosis 1073 100.00 Very High Very High Very High
Headache 237 100.00 Very High Very High Very High
Brain Injury 48 100.00 Very High Very High Very High
Disease 238 99.84 Very High Very High Very High
Cystic Fibrosis 73 99.84 Very High Very High Very High
Hyperplasia 142 99.80 Very High Very High Very High
Pruritus 137 99.80 Very High Very High Very High
Kidney Stones 110 99.80 Very High Very High Very High
Hypercalcemia 920 99.76 Very High Very High Very High
Chronic Renal Failure 454 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fourteen cases were cured of their symptoms and their serum PTH levels was restored to normal.
Gene_expression (levels) of PTH
1) Confidence 0.76 Published 1991 Journal Hinyokika Kiyo Section Abstract Doc Link 1755413 Disease Relevance 0.36 Pain Relevance 0.09
PTH is produced as a fusion protein.
Gene_expression (produced) of PTH
2) Confidence 0.76 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0.12 Pain Relevance 0
To investigate the occurrence of hypocalcaemia and elevated PTH levels and their relationship to morality and the severity of disease, serum levels of PTH, ionized calcium (Ca2+) and the cytokines interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-alpha) were measured on arrival in the emergency department in a broad spectrum of 140 acutely ill patients patients suffering from common diseases such as stroke, acute abdominal disorders, obstructive lung diseases, heart failure, acute myocardial infarction, angina pectoris, trauma and infectious diseases.
Gene_expression (levels) of PTH in heart associated with hypocalcemia, angina, stroke, disease, cytokine, obstructive airway disease, necrosis, emergencies, cancer, communicable diseases, injury and myocardial infarction
3) Confidence 0.74 Published 1997 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 9466123 Disease Relevance 1.51 Pain Relevance 0.13
Under normal conditions, calcitriol regulates the expression of PTH by suppressing transcription of pre-pro-PTH messenger RNA (Russell et al 1986; Silver et al 1986).
Gene_expression (expression) of PTH
4) Confidence 0.73 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.49 Pain Relevance 0
Prostate cancer bony metastases show increased expression of the PTH receptor (PTH-IR) and PTH promotes the growth and invasiveness of prostate cancer cells in bone.
Gene_expression (expression) of PTH associated with metastasis and reprotox - general 1
5) Confidence 0.71 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.26 Pain Relevance 0.06
Prostate cancer bony metastases show increased expression of the PTH receptor (PTH-IR) and PTH promotes the growth and invasiveness of prostate cancer cells in bone.
Gene_expression (expression) of PTH associated with metastasis and reprotox - general 1
6) Confidence 0.71 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.26 Pain Relevance 0.06
Prostate cancer bony metastases show increased expression of the PTH receptor (PTH-IR) and PTH promotes the growth and invasiveness of prostate cancer cells in bone.
Gene_expression (expression) of PTH associated with metastasis and reprotox - general 1
7) Confidence 0.71 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.25 Pain Relevance 0.06
This concurs, however, with the increases that we found after recovering treatment (after osteopenia) with PTH in the epiphysis.
Gene_expression (recovering) of PTH in epiphysis associated with osteoporosis
8) Confidence 0.68 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2765647 Disease Relevance 0.10 Pain Relevance 0
This was done for the PTH-treated rats only.


Gene_expression (rats) of PTH-treated
9) Confidence 0.68 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2765647 Disease Relevance 0 Pain Relevance 0
CONCLUSION: This case suggests that despite the potential complex pathophysiologic aspects of calciphylaxis, even in the absence of both renal failure and an elevated calcium/phosphorus product, early parathyroidectomy in patients with appreciably increased PTH levels may improve wound healing and diminish pain.


Gene_expression (levels) of PTH
10) Confidence 0.67 Published 2006 Journal Endocr Pract Section Body Doc Link 16901796 Disease Relevance 0 Pain Relevance 0
There were statistically significant differences for lumbar spinal BMD mean percentage change from baseline in favour of PTH 75 ?
Gene_expression (favour) of PTH in spinal
11) Confidence 0.66 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0 Pain Relevance 0
Parathyroid hormone physiology
Gene_expression (physiology) of Parathyroid hormone in Parathyroid
12) Confidence 0.66 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0.15 Pain Relevance 0
The PTH followed by Pcb group experienced a significant decrease in lumbar spine BMD (?
Gene_expression (experienced) of PTH in spine
13) Confidence 0.66 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0 Pain Relevance 0
As early as 1929, Albright and colleagues (Bauer et al 1929) and later Selye (1932) observed that PTH, in fact yet a “peptide extract”, could also be anabolic to the skeleton, producing increases in bone tissue in animals.
Gene_expression (anabolic) of PTH in bone tissue
14) Confidence 0.66 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0.32 Pain Relevance 0
The PTH followed by Pcb group experienced a significant decrease in lumbar spine BMD (?
Gene_expression (followed) of PTH in spine
15) Confidence 0.66 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0 Pain Relevance 0
Nevertheless, the C terminal receptor for pTH is still not universally accepted therefore only the PTH1R receptor is considered specific.


Neg (not) Gene_expression (accepted) of pTH
16) Confidence 0.66 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0.25 Pain Relevance 0
2.5 SD below the mean of healthy young women) were randomized to receive PTH 50 ?
Gene_expression (receive) of PTH
17) Confidence 0.66 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0.32 Pain Relevance 0
There was no significant change in cortical volumetric BMD in either the PTH followed by ALN or PTH followed by Pcb groups.
Gene_expression (followed) of PTH
18) Confidence 0.66 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0 Pain Relevance 0
Moreover, no evidence of any adverse effect on osteoblast function could be seen, and there was no correlation between bone lanthanum content and parathyroid hormone levels.


Gene_expression (levels) of parathyroid hormone in parathyroid associated with osteoporosis
19) Confidence 0.66 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621404 Disease Relevance 0.85 Pain Relevance 0.06
In rat carotid arteries, the RNase protection assay and in situ hybridization demonstrated that PTHrP mRNA expression increased fourfold to sixfold 1 to 7 days after denudation and continued for 28 days, coincident with downregulation of PTH/PTHrP receptor mRNA expression.
Gene_expression (expression) of PTH
20) Confidence 0.65 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.35 Pain Relevance 0.11

General Comments

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